Reactome | GGA1 [early endosome membrane]

GGA1 [early endosome membrane]

Stable Identifier

R-HSA-8854136

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

early endosome membrane

Synonyms

ADP-ribosylation factor-binding protein GGA1, GGA1_HUMAN

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Rab regulation of trafficking (Homo sapiens)
    - TBC/RABGAPs (Homo sapiens)
      - TBC1D3 associates with RAB5 (Homo sapiens)
        
        GGA1,2,3:RAB5:GTP:RABGEF1 [early endosome membrane] (Homo sapiens)
        
        GGA1,2,3 [early endosome membrane] (Homo sapiens)
        
        GGA1 [early endosome membrane] (Homo sapiens)
        
        TBC1D3:GGA:RAB5:GTP:RABGEF1 [early endosome membrane] (Homo sapiens)
        
        GGA1,2,3:RAB5:GTP:RABGEF1 [early endosome membrane] (Homo sapiens)
        
        GGA1,2,3 [early endosome membrane] (Homo sapiens)
        
        GGA1 [early endosome membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UJY5 GGA1

Gene Names

GGA1

Chain

chain:1-639

Reference Genes

BioGPS Gene:26088 GGA1

COSMIC (genes):GGA1 GGA1

CTD Gene:26088 GGA1

dbSNP Gene:26088 GGA1

ENSEMBL:ENSG00000100083 GGA1

HGNC:17842 GGA1

KEGG Gene (Homo sapiens):26088 GGA1

Monarch:26088 GGA1

NCBI Gene:26088 GGA1

OMIM:606004 GGA1

UCSC:Q9UJY5 GGA1

Reference Transcript

Other Identifiers

0002810400

11736096_a_at

11736097_a_at

16929782

218114_3p_at

218114_at

3944780

3944781

3944782

3944783

3944784

3944791

3944792

3944793

3944797

3944798

3944799

3944800

3944801

3944802

3944805

3944809

3944810

3944814

3944815

3944816

3944818

3944820

3944821

3944822

3944823

3944825

45572_s_at

50277_at

8072825

A_23_P132294

A_33_P3305915

GE61116

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005737

GO:0005768

GO:0005769

GO:0005794

GO:0005829

GO:0006810

GO:0006886

GO:0006893

GO:0008104

GO:0008150

GO:0009056

GO:0010008

GO:0015031

GO:0016020

GO:0016192

GO:0019899

GO:0030306

GO:0031410

GO:0031901

GO:0032991

GO:0034394

GO:0042147

GO:0043001

GO:0043226

GO:0043231

GO:0044267

GO:0045732

GO:1901998

GO:1903441

ILMN_1658175

ILMN_1681668

ILMN_2403851

PH_hs_0033137

TC22000283.hg

g9558728_3p_at

g9558728_3p_s_at

Participant Of

hasMember

GGA1,2,3 [early endosome membrane]

Other forms of this molecule

GGA1 [endosome membrane]

Inferred To

gga1 [early endosome membrane] (Danio rerio)

Gga [early endosome membrane] (Drosophila melanogaster)

apt-9 [early endosome membrane] (Caenorhabditis elegans)

GGA1 [early endosome membrane] (Canis familiaris)

GGA1 [early endosome membrane] (Gallus gallus)

GGA1 [early endosome membrane] (Sus scrofa)

GGA1 [early endosome membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_001001560.1, NP_001166158.1, XP_016884251.1, XP_006724292.1, XP_016884250.1, NP_001166159.1, NP_037497.1, XP_016884249.1, XP_005261577.1, XP_011528424.1, XP_005261574.1

OpenTargets

ENSG00000100083

HPA

ENSG00000100083-GGA1

GeneCards

Q9UJY5

Ensembl

ENSG00000100083, ENSP00000341344, ENST00000343632, ENST00000325180, ENST00000381756, ENST00000406772, ENSP00000371175, ENSP00000385287, ENSP00000321288

PRO

Q9UJY5

HMDB Protein

HMDBP08420

PDB

1OXZ, 3G2V, 2DWY, 1NWM, 1PY1, 1JWG, 1OM9, 1J2J, 3G2U, 1JWF, 1O3X, 2DWX, 1UJK, 1NA8, 3G2T, 1UJJ, 3G2W, 1X79, 1NAF, 3G2S

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q92673 SORL1	2	SORL1 [endosome membrane] (R-HSA-8871475) SORL1 [Golgi membrane] (R-HSA-8871510)	0.744	5
UniProt:P56817 BACE1	8	7K-BACE1 [endoplasmic reticulum lumen] (R-HSA-5693006) BACE1 [endoplasmic reticulum lumen] (R-HSA-6783326) BACE1(22-45) [Golgi-associated vesicle lumen] (R-HSA-5693069) 7K-BACE1 [Golgi-associated vesicle lumen] (R-HSA-5693095) 7K-BACE1(46-501) [Golgi-associated vesicle lumen] (R-HSA-5693106) BACE1(46-501) [Golgi-associated vesicle lumen] (R-HSA-5693105) BACE1(46-501) [plasma membrane] (R-HSA-5692933) BACE1 [endosome membrane] (R-HSA-5692942)	0.684	4
UniProt:P0CG47 UBB	112	UBB(1-76) [endocytic vesicle membrane] (R-HSA-939231) UBB(77-152) [endocytic vesicle membrane] (R-HSA-939253) UBB(153-228) [endocytic vesicle membrane] (R-HSA-939171) Ub-33-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783023) Ub-110-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783008) Ub-186-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783046) Ub-215-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783002) Ub-63-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783148) Ub-139-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783012) Ub-158-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783162) Ub-6-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783014) Ub-82-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783015) Ub-163-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783025) Ub-87-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6782998) Ub-11-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783109) Ub-124-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783131) Ub-200-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783100) Ub-48-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783165) Ub-182-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783160) Ub-29-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783070) Ub-106-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783103) Ub-27-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783038) Ub-180-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783114) Ub-104-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783149) N6-glycyl-L-lysine-UBB(1-76) [cytosol] (R-HSA-8869049) N6-glycyl-L-lysine-UBB(153-228) [cytosol] (R-HSA-8869046) N6-glycyl-L-lysine-UBB(77-152) [cytosol] (R-HSA-8869047) Ub-106-UBB(77-152) [cytosol] (R-HSA-5689191) Ub-182-UBB(153-228) [cytosol] (R-HSA-5689214) Ub-29-UBB(1-76) [cytosol] (R-HSA-5689207) Ub-158-UBB(153-228) [cytosol] (R-HSA-5689099) Ub-82-UBB(77-152) [cytosol] (R-HSA-5689080) Ub-6-UBB(1-76) [cytosol] (R-HSA-5689075) Ub-33-UBB(1-76) [cytosol] (R-HSA-5689198) Ub-186-UBB(153-228) [cytosol] (R-HSA-5689146) Ub-110-UBB(77-152) [cytosol] (R-HSA-5689203) adenylatedG152-UBB(77-152) [nucleoplasm] (R-HSA-8852094) adenylatedG228-UBB(153-228) [nucleoplasm] (R-HSA-8852104) adenylatedG76-UBB(1-76) [nucleoplasm] (R-HSA-8852101) UBB [cytosol] (R-HSA-8853516) adenylatedG76-UBB(1-76) [cytosol] (R-HSA-8852121) adenylatedG228-UBB(153-228) [cytosol] (R-HSA-8852049) adenylatedG152-UBB(77-152) [cytosol] (R-HSA-8852113) Ub-124-UBB(77-152) [endoplasmic reticulum membrane] (R-HSA-8943100) Ub-48-UBB(1-76) [endoplasmic reticulum membrane] (R-HSA-8943138) Ub-200-UBB(153-228) [endoplasmic reticulum membrane] (R-HSA-8943117) UBB(153-228) [endoplasmic reticulum membrane] (R-HSA-8943098) UBB(77-152) [endoplasmic reticulum membrane] (R-HSA-8943111) UBB(1-76) [endoplasmic reticulum membrane] (R-HSA-8943078) UBB(153-228) [plasma membrane] (R-HSA-3149455) UBB(1-76) [plasma membrane] (R-HSA-3149453) UBB(77-152) [plasma membrane] (R-HSA-3149463) UBB(77-152) [endosome membrane] (R-HSA-939251) UBB(1-76) [endosome membrane] (R-HSA-939240) UBB(153-228) [endosome membrane] (R-HSA-939247) Ub-27-UBB(1-76) [cytosol] (R-HSA-5689161) Ub-104-UBB(77-152) [cytosol] (R-HSA-5689139) Ub-180-UBB(153-228) [cytosol] (R-HSA-5689138) Ub-11-UBB(1-76) [cytosol] (R-HSA-3095929) Ub-163-UBB(153-228) [cytosol] (R-HSA-3095932) Ub-87-UBB(77-152) [cytosol] (R-HSA-3095917) Ub-139-UBB(77-152) [endosome membrane] (R-HSA-939217) Ub-215-UBB(153-228) [endosome membrane] (R-HSA-939193) Ub-63-UBB(1-76) [endosome membrane] (R-HSA-939167) Ub-139-UBB(77-152) [plasma membrane] (R-HSA-939867) Ub-63-UBB(1-76) [plasma membrane] (R-HSA-939872) Ub-215-UBB(153-228) [plasma membrane] (R-HSA-939852) Ub-27-UBB(1-76) [nucleoplasm] (R-HSA-6782673) Ub-180-UBB(153-228) [nucleoplasm] (R-HSA-6782604) Ub-104-UBB(77-152) [nucleoplasm] (R-HSA-6782627) Ub-106-UBB(77-152) [nucleoplasm] (R-HSA-6782652) Ub-182-UBB(153-228) [nucleoplasm] (R-HSA-6782665) Ub-29-UBB(1-76) [nucleoplasm] (R-HSA-6782595) Ub-139-UBB(77-152) [nucleoplasm] (R-HSA-6782488) Ub-63-UBB(1-76) [nucleoplasm] (R-HSA-6782489) Ub-215-UBB(153-228) [nucleoplasm] (R-HSA-6782475) Ub-124-UBB(77-152) [nucleoplasm] (R-HSA-6782527) Ub-48-UBB(1-76) [nucleoplasm] (R-HSA-6782505) Ub-200-UBB(153-228) [nucleoplasm] (R-HSA-6782478) Ub-11-UBB(1-76) [nucleoplasm] (R-HSA-6782649) Ub-87-UBB(77-152) [nucleoplasm] (R-HSA-6782607) Ub-163-UBB(153-228) [nucleoplasm] (R-HSA-6782598) Ub-186-UBB(153-228) [nucleoplasm] (R-HSA-6782655) Ub-110-UBB(77-152) [nucleoplasm] (R-HSA-6782591) Ub-33-UBB(1-76) [nucleoplasm] (R-HSA-6782601) Ub-82-UBB(77-152) [nucleoplasm] (R-HSA-6782683) Ub-6-UBB(1-76) [nucleoplasm] (R-HSA-6782600) Ub-158-UBB(153-228) [nucleoplasm] (R-HSA-6782639) UBB(77-152) [nucleoplasm] (R-HSA-939870) UBB(1-76) [nucleoplasm] (R-HSA-939847) UBB(153-228) [nucleoplasm] (R-HSA-939854) Ub-48-UBB(1-76) [nucleoplasm] (R-HSA-5683040) Ub-124-UBB(77-152) [nucleoplasm] (R-HSA-5683036) Ub-200-UBB(153-228) [nucleoplasm] (R-HSA-5683038) Ub-139-UBB(77-152) [nucleoplasm] (R-HSA-5682845) Ub-215-UBB(153-228) [nucleoplasm] (R-HSA-5682844) Ub-63-UBB(1-76) [nucleoplasm] (R-HSA-5682846) UBB(153-228) [late endosome lumen] (R-HSA-9660014) UBB(77-152) [late endosome lumen] (R-HSA-9660021) UBB(1-76) [late endosome lumen] (R-HSA-9660017) Ub-48-UBB(1-76) [cytosol] (R-HSA-939249) Ub-124-UBB(77-152) [cytosol] (R-HSA-939225) Ub-200-UBB(153-228) [cytosol] (R-HSA-939197) UBB(153-228) [cytosol] (R-HSA-939230) UBB(77-152) [cytosol] (R-HSA-939213) UBB(1-76) [cytosol] (R-HSA-939214) UBB(77-152) [lysosomal lumen] (R-HSA-9660011) UBB(1-76) [lysosomal lumen] (R-HSA-9660024) UBB(153-228) [lysosomal lumen] (R-HSA-9660025) Ub-63-UBB(1-76) [cytosol] (R-HSA-939224) Ub-215-UBB(153-228) [cytosol] (R-HSA-939168) Ub-139-UBB(77-152) [cytosol] (R-HSA-939235)	0.581	3
UniProt:P84080	2	ARF1 [Golgi membrane] (R-BTA-199971) ARF1 [cytosol] (R-BTA-200826)	0.527	2
UniProt:Q9NZ52 GGA3	3	GGA3 [early endosome membrane] (R-HSA-8854137) GGA3 [endosome membrane] (R-HSA-5692936) GGA3 [recycling endosome membrane] (R-HSA-8875655)	0.508	4