Reactome | GGA1 [early endosome membrane]

GGA1 [early endosome membrane]

Stable Identifier

R-HSA-8854136

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

early endosome membrane

Synonyms

ADP-ribosylation factor-binding protein GGA1, GGA1_HUMAN

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Rab regulation of trafficking (Homo sapiens)
    - TBC/RABGAPs (Homo sapiens)
      - TBC1D3 associates with RAB5 (Homo sapiens)
        
        GGA1,2,3:RAB5:GTP:RABGEF1 [early endosome membrane] (Homo sapiens)
        
        GGA1,2,3 [early endosome membrane] (Homo sapiens)
        
        GGA1 [early endosome membrane] (Homo sapiens)
        
        TBC1D3:GGA:RAB5:GTP:RABGEF1 [early endosome membrane] (Homo sapiens)
        
        GGA1,2,3:RAB5:GTP:RABGEF1 [early endosome membrane] (Homo sapiens)
        
        GGA1,2,3 [early endosome membrane] (Homo sapiens)
        
        GGA1 [early endosome membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UJY5 GGA1

Gene Names

GGA1

Chain

chain:1-639

Reference Genes

BioGPS Gene:26088 GGA1

COSMIC (genes):GGA1 GGA1

CTD Gene:26088 GGA1

dbSNP Gene:26088 GGA1

ENSEMBL:ENSG00000100083 GGA1

HGNC:17842 GGA1

KEGG Gene (Homo sapiens):26088 GGA1

Monarch:26088 GGA1

NCBI Gene:26088 GGA1

OMIM:606004 GGA1

UCSC:Q9UJY5 GGA1

Reference Transcript

Other Identifiers

0002810400

11736096_a_at

11736097_a_at

16929782

1J2J

1JWF

1JWG

1NA8

1NAF

1NWM

1O3X

1OM9

1OXZ

1PY1

1UJJ

1UJK

1X79

218114_3p_at

218114_at

26088

2DWX

2DWY

3944780

3944781

3944782

3944783

3944784

3944791

3944792

3944793

3944797

3944798

3944799

3944800

3944801

3944802

3944805

3944809

3944810

3944814

3944815

3944816

3944818

3944820

3944821

3944822

3944823

3944825

3G2S

3G2T

3G2U

3G2V

3G2W

45572_s_at

48280

50277_at

51016

8072825

A_23_P132294

A_33_P3305915

AAF05707

AAF35393

AAF42847

AAH00538

AAH10917

AAH29388

AAH44629

AF190862

AF218584

AF233521

AK075256

AK122898

AK290548

AL035496

AL110219

B0QYR5

B0QYR6

B0QYR9

B0QYS0

B0QYS1

B0QYS2

B0QYS3

B0QYS5

BAC11501

BAF83237

BAG53788

BC000538

BC010917

BC029388

BC044629

CAB53679

CAG30379

CCDS13951

CCDS33643

CCDS54526

CCDS87022

CH471095

CR456493

EAW60169

ENSG00000100083

ENSP00000321288

ENSP00000341344

ENSP00000371175

ENSP00000385287

ENST00000325180

ENST00000325180.12

ENST00000343632

ENST00000343632.8

ENST00000381756

ENST00000381756.9

ENST00000406772

ENST00000406772.5

EntrezGene:26088

EntrezGene:GGA1

g9558728_3p_at

g9558728_3p_s_at

GE61116

GGA1

GGA1-201

GGA1-203

GGA1-204

GGA1-206

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005737

GO:0005768

GO:0005769

GO:0005794

GO:0005829

GO:0006810

GO:0006886

GO:0006893

GO:0008104

GO:0008150

GO:0009056

GO:0010008

GO:0015031

GO:0016020

GO:0016192

GO:0019899

GO:0030306

GO:0031410

GO:0031901

GO:0032991

GO:0034394

GO:0042147

GO:0043001

GO:0043226

GO:0043231

GO:0044267

GO:0045732

GO:0046982

GO:1901998

GO:1903441

HGNC:17842

HPA048280

HPA051016

ILMN_1658175

ILMN_1681668

ILMN_2403851

IPR002014

IPR004152

IPR008152

IPR008153

IPR008942

IPR013041

IPR038425

IPR041198

MIM:606004

NM_001001560

NM_001172687

NM_001172688

NM_001363771

NM_013365

NP_001001560

NP_001166158

NP_001166159

NP_001350700

NP_037497

PF00790

PF02883

PF03127

PF18308

PH_hs_0033137

SM00288

SM00809

TC22000283.hg

UPI0000001BEE

UPI000000DA9D

UPI000003E7D9

UPI00003765B2

XM_005261518

XM_005261520

XM_005261522

XM_006724229

XM_011530123

XM_017028761

XM_017028763

XM_017028764

XM_017028765

XM_024452214

XM_024452215

XM_024452216

XM_024452217

XP_005261575

XP_005261577

XP_005261579

XP_006724292

XP_011528425

XP_016884250

XP_016884252

XP_016884253

XP_016884254

XP_024307982

XP_024307983

XP_024307984

XP_024307985

XR_002958683

XR_002958684

Z83844

Participant Of

hasMember

GGA1,2,3 [early endosome membrane]

Other forms of this molecule

GGA1 [endosome membrane]

Inferred To

GGA1 [early endosome membrane] (Caenorhabditis elegans)

GGA1 [early endosome membrane] (Canis familiaris)

GGA1 [early endosome membrane] (Danio rerio)

GGA1 [early endosome membrane] (Drosophila melanogaster)

GGA1 [early endosome membrane] (Gallus gallus)

GGA1 [early endosome membrane] (Sus scrofa)

GGA1 [early endosome membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_001001560.1, XP_005261574.1, XP_016884251.1, XP_016884250.1, NP_037497.1, NP_001166159.1, XP_006724292.1, XP_016884249.1, XP_011528424.1, NP_001166158.1, XP_005261577.1

OpenTargets

ENSG00000100083

GeneCards

Q9UJY5

PRO

Q9UJY5

HMDB Protein

HMDBP08420

PDB

3G2W, 1UJJ, 1UJK, 1OM9, 3G2S, 1NAF, 3G2T, 1OXZ, 3G2U, 1O3X, 3G2V, 1JWF, 1JWG, 1PY1, 2DWX, 2DWY, 1X79, 1NA8, 1NWM, 1J2J

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q92673 SORL1	2	SORL1 [endosome membrane] (R-HSA-8871475) SORL1 [Golgi membrane] (R-HSA-8871510)	0.744	5
UniProt:P56817 BACE1	8	7K-BACE1 [endoplasmic reticulum lumen] (R-HSA-5693006) BACE1 [endoplasmic reticulum lumen] (R-HSA-6783326) BACE1(22-45) [Golgi-associated vesicle lumen] (R-HSA-5693069) 7K-BACE1 [Golgi-associated vesicle lumen] (R-HSA-5693095) 7K-BACE1(46-501) [Golgi-associated vesicle lumen] (R-HSA-5693106) BACE1(46-501) [Golgi-associated vesicle lumen] (R-HSA-5693105) BACE1(46-501) [plasma membrane] (R-HSA-5692933) BACE1 [endosome membrane] (R-HSA-5692942)	0.684	4
UniProt:P0CG47 UBB	106	UBB(1-76) [endocytic vesicle membrane] (R-HSA-939231) UBB(77-152) [endocytic vesicle membrane] (R-HSA-939253) UBB(153-228) [endocytic vesicle membrane] (R-HSA-939171) Ub-33-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783023) Ub-110-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783008) Ub-186-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783046) Ub-215-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783002) Ub-63-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783148) Ub-139-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783012) Ub-158-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783162) Ub-6-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783014) Ub-82-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783015) Ub-163-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783025) Ub-87-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6782998) Ub-11-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783109) Ub-124-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783131) Ub-200-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783100) Ub-48-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783165) Ub-182-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783160) Ub-29-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783070) Ub-106-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783103) Ub-27-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783038) Ub-180-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783114) Ub-104-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783149) N6-glycyl-L-lysine-UBB(1-76) [cytosol] (R-HSA-8869049) N6-glycyl-L-lysine-UBB(153-228) [cytosol] (R-HSA-8869046) N6-glycyl-L-lysine-UBB(77-152) [cytosol] (R-HSA-8869047) Ub-106-UBB(77-152) [cytosol] (R-HSA-5689191) Ub-182-UBB(153-228) [cytosol] (R-HSA-5689214) Ub-29-UBB(1-76) [cytosol] (R-HSA-5689207) Ub-158-UBB(153-228) [cytosol] (R-HSA-5689099) Ub-82-UBB(77-152) [cytosol] (R-HSA-5689080) Ub-6-UBB(1-76) [cytosol] (R-HSA-5689075) Ub-33-UBB(1-76) [cytosol] (R-HSA-5689198) Ub-186-UBB(153-228) [cytosol] (R-HSA-5689146) Ub-110-UBB(77-152) [cytosol] (R-HSA-5689203) adenylatedG152-UBB(77-152) [nucleoplasm] (R-HSA-8852094) adenylatedG228-UBB(153-228) [nucleoplasm] (R-HSA-8852104) adenylatedG76-UBB(1-76) [nucleoplasm] (R-HSA-8852101) UBB [cytosol] (R-HSA-8853516) adenylatedG76-UBB(1-76) [cytosol] (R-HSA-8852121) adenylatedG228-UBB(153-228) [cytosol] (R-HSA-8852049) adenylatedG152-UBB(77-152) [cytosol] (R-HSA-8852113) Ub-124-UBB(77-152) [endoplasmic reticulum membrane] (R-HSA-8943100) Ub-48-UBB(1-76) [endoplasmic reticulum membrane] (R-HSA-8943138) Ub-200-UBB(153-228) [endoplasmic reticulum membrane] (R-HSA-8943117) UBB(153-228) [endoplasmic reticulum membrane] (R-HSA-8943098) UBB(77-152) [endoplasmic reticulum membrane] (R-HSA-8943111) UBB(1-76) [endoplasmic reticulum membrane] (R-HSA-8943078) UBB(153-228) [plasma membrane] (R-HSA-3149455) UBB(1-76) [plasma membrane] (R-HSA-3149453) UBB(77-152) [plasma membrane] (R-HSA-3149463) UBB(77-152) [endosome membrane] (R-HSA-939251) UBB(1-76) [endosome membrane] (R-HSA-939240) UBB(153-228) [endosome membrane] (R-HSA-939247) Ub-27-UBB(1-76) [cytosol] (R-HSA-5689161) Ub-104-UBB(77-152) [cytosol] (R-HSA-5689139) Ub-180-UBB(153-228) [cytosol] (R-HSA-5689138) Ub-11-UBB(1-76) [cytosol] (R-HSA-3095929) Ub-163-UBB(153-228) [cytosol] (R-HSA-3095932) Ub-87-UBB(77-152) [cytosol] (R-HSA-3095917) Ub-139-UBB(77-152) [endosome membrane] (R-HSA-939217) Ub-215-UBB(153-228) [endosome membrane] (R-HSA-939193) Ub-63-UBB(1-76) [endosome membrane] (R-HSA-939167) Ub-139-UBB(77-152) [plasma membrane] (R-HSA-939867) Ub-63-UBB(1-76) [plasma membrane] (R-HSA-939872) Ub-215-UBB(153-228) [plasma membrane] (R-HSA-939852) Ub-27-UBB(1-76) [nucleoplasm] (R-HSA-6782673) Ub-180-UBB(153-228) [nucleoplasm] (R-HSA-6782604) Ub-104-UBB(77-152) [nucleoplasm] (R-HSA-6782627) Ub-106-UBB(77-152) [nucleoplasm] (R-HSA-6782652) Ub-182-UBB(153-228) [nucleoplasm] (R-HSA-6782665) Ub-29-UBB(1-76) [nucleoplasm] (R-HSA-6782595) Ub-139-UBB(77-152) [nucleoplasm] (R-HSA-6782488) Ub-63-UBB(1-76) [nucleoplasm] (R-HSA-6782489) Ub-215-UBB(153-228) [nucleoplasm] (R-HSA-6782475) Ub-124-UBB(77-152) [nucleoplasm] (R-HSA-6782527) Ub-48-UBB(1-76) [nucleoplasm] (R-HSA-6782505) Ub-200-UBB(153-228) [nucleoplasm] (R-HSA-6782478) Ub-11-UBB(1-76) [nucleoplasm] (R-HSA-6782649) Ub-87-UBB(77-152) [nucleoplasm] (R-HSA-6782607) Ub-163-UBB(153-228) [nucleoplasm] (R-HSA-6782598) Ub-186-UBB(153-228) [nucleoplasm] (R-HSA-6782655) Ub-110-UBB(77-152) [nucleoplasm] (R-HSA-6782591) Ub-33-UBB(1-76) [nucleoplasm] (R-HSA-6782601) Ub-82-UBB(77-152) [nucleoplasm] (R-HSA-6782683) Ub-6-UBB(1-76) [nucleoplasm] (R-HSA-6782600) Ub-158-UBB(153-228) [nucleoplasm] (R-HSA-6782639) UBB(77-152) [nucleoplasm] (R-HSA-939870) UBB(1-76) [nucleoplasm] (R-HSA-939847) UBB(153-228) [nucleoplasm] (R-HSA-939854) Ub-48-UBB(1-76) [nucleoplasm] (R-HSA-5683040) Ub-124-UBB(77-152) [nucleoplasm] (R-HSA-5683036) Ub-200-UBB(153-228) [nucleoplasm] (R-HSA-5683038) Ub-139-UBB(77-152) [nucleoplasm] (R-HSA-5682845) Ub-215-UBB(153-228) [nucleoplasm] (R-HSA-5682844) Ub-63-UBB(1-76) [nucleoplasm] (R-HSA-5682846) Ub-48-UBB(1-76) [cytosol] (R-HSA-939249) Ub-124-UBB(77-152) [cytosol] (R-HSA-939225) Ub-200-UBB(153-228) [cytosol] (R-HSA-939197) UBB(153-228) [cytosol] (R-HSA-939230) UBB(77-152) [cytosol] (R-HSA-939213) UBB(1-76) [cytosol] (R-HSA-939214) Ub-63-UBB(1-76) [cytosol] (R-HSA-939224) Ub-215-UBB(153-228) [cytosol] (R-HSA-939168) Ub-139-UBB(77-152) [cytosol] (R-HSA-939235)	0.581	3
UniProt:P84080	2	ARF1 [Golgi membrane] (R-BTA-199971) ARF1 [cytosol] (R-BTA-200826)	0.527	2
UniProt:Q9NZ52 GGA3	3	GGA3 [recycling endosome membrane] (R-HSA-8875655) GGA3 [endosome membrane] (R-HSA-5692936) GGA3 [early endosome membrane] (R-HSA-8854137)	0.508	4