Reactome | GGA2 [early endosome membrane]

GGA2 [early endosome membrane]

Stable Identifier

R-HSA-8854140

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

early endosome membrane

Synonyms

ADP-ribosylation factor-binding protein GGA2, GGA2_HUMAN

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Rab regulation of trafficking (Homo sapiens)
    - TBC/RABGAPs (Homo sapiens)
      - TBC1D3 associates with RAB5 (Homo sapiens)
        
        GGA1,2,3:RAB5:GTP:RABGEF1 [early endosome membrane] (Homo sapiens)
        
        GGA1,2,3 [early endosome membrane] (Homo sapiens)
        
        GGA2 [early endosome membrane] (Homo sapiens)
        
        TBC1D3:GGA:RAB5:GTP:RABGEF1 [early endosome membrane] (Homo sapiens)
        
        GGA1,2,3:RAB5:GTP:RABGEF1 [early endosome membrane] (Homo sapiens)
        
        GGA1,2,3 [early endosome membrane] (Homo sapiens)
        
        GGA2 [early endosome membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UJY4 GGA2

Gene Names

GGA2, KIAA1080

Chain

chain:1-613

Reference Genes

BioGPS Gene:23062 GGA2

COSMIC (genes):GGA2 GGA2

CTD Gene:23062 GGA2

dbSNP Gene:23062 GGA2

ENSEMBL:ENSG00000103365 GGA2

HGNC:16064 GGA2

KEGG:hsa:23062 GGA2

Monarch:23062 GGA2

NCBI Gene:23062 GGA2

OMIM:606005 GGA2

UCSC:Q9UJY4 GGA2

Reference Transcript

RefSeq:NM_015044.4 GGA2

Other Identifiers

11722372_a_at

11722373_a_at

11722374_a_at

11722375_a_at

16825057

208913_PM_at

208913_at

208914_PM_at

208914_at

208915_PM_s_at

208915_s_at

210658_PM_s_at

210658_s_at

213772_PM_s_at

213772_s_at

214190_PM_x_at

214190_x_at

23062

3685184

3685185

3685186

3685187

3685188

3685189

3685190

3685191

3685192

3685193

3685194

3685195

3685196

3685197

3685198

3685199

3685200

3685201

3685202

3685203

3685204

3685205

3685206

3685210

3685211

3685213

3685215

3685216

3685218

3685219

3685222

3685223

3685228

3685230

3685232

3685233

3685234

3685235

3685236

3685241

3685242

3685260

3685262

40278_at

8000284

85201_at

86257_at

A_23_P163732

A_24_P416257

A_32_P106117

GE79376

GO:0005515

GO:0005768

GO:0005794

GO:0005802

GO:0006886

GO:0006893

GO:0008289

GO:0010008

GO:0015031

GO:0016020

GO:0016192

GO:0030136

GO:0031267

GO:0031410

GO:0031901

GO:0034394

GO:0035091

GO:0043001

GO:0043130

GO:0043226

GO:0072659

GO:0097708

HMNXSV003008326

HMNXSV003011321

Hs.155546.0.S3_3p_at

Hs.155546.0.S4_3p_at

Hs.155546.2.S1_3p_a_at

Hs.155546.4.S1_3p_a_at

ILMN_1686152

PH_hs_0022504

TC16000963.hg

g12653040_3p_a_at

g6179913_3p_a_at

Participates

as a member of

GGA1,2,3 [early endosome membrane] (Homo sapiens)

Other forms of this molecule

GGA2 [endosome membrane]

Inferred To

GGA2 [early endosome membrane] (Gallus gallus)

GGA2 [early endosome membrane] (Sus scrofa)

Gga [early endosome membrane] (Drosophila melanogaster)

apt-9 [early endosome membrane] (Caenorhabditis elegans)

Cross References

ENSEMBL

ENST00000309859, ENSP00000311962

OpenTargets

ENSG00000103365

HPA

ENSG00000103365-GGA2

PRO

Q9UJY4

Pharos - Targets

Q9UJY4

GlyGen

Q9UJY4

HMDB Protein

HMDBP08421

PDB

1MHQ

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q92673 SORL1	2	SORL1 [endosome membrane] (R-HSA-8871475) SORL1 [Golgi membrane] (R-HSA-8871510)	0.774	6
UniProt:Q9Y316 MEMO1	1	MEMO1 [cytosol] (R-HSA-6785630)	0.556	3
UniProt:P56817 BACE1	8	BACE1 [endoplasmic reticulum lumen] (R-HSA-6783326) 7K-BACE1 [endoplasmic reticulum lumen] (R-HSA-5693006) BACE1(22-45) [Golgi-associated vesicle lumen] (R-HSA-5693069) 7K-BACE1 [Golgi-associated vesicle lumen] (R-HSA-5693095) 7K-BACE1(46-501) [Golgi-associated vesicle lumen] (R-HSA-5693106) BACE1(46-501) [Golgi-associated vesicle lumen] (R-HSA-5693105) BACE1(46-501) [plasma membrane] (R-HSA-5692933) BACE1 [endosome membrane] (R-HSA-5692942)	0.544	2
UniProt:P84080	2	ARF1 [cytosol] (R-BTA-200826) ARF1 [Golgi membrane] (R-BTA-199971)	0.527	2
UniProt:Q9NZ52 GGA3	3	GGA3 [endosome membrane] (R-HSA-5692936) GGA3 [early endosome membrane] (R-HSA-8854137) GGA3 [recycling endosome membrane] (R-HSA-8875655)	0.508	3
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.488	2