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TBC1D15 [cytosol]
Stable Identifier
R-HSA-8854150
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
TBC1 domain family member 15, TBC15_HUMAN
Locations in the PathwayBrowser
Expand all
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Rab regulation of trafficking (Homo sapiens)
TBC/RABGAPs (Homo sapiens)
TBC1D15 accelerates GTP hydrolysis by RAB7 (Homo sapiens)
TBC1D15 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8TC07 TBC1D15
Gene Names
TBC1D15
Chain
initiator methionine:1, chain:2-691
Reference Genes
BioGPS Gene:64786 TBC1D15
COSMIC (genes):TBC1D15 TBC1D15
CTD Gene:64786 TBC1D15
dbSNP Gene:64786 TBC1D15
ENSEMBL:ENSG00000121749 TBC1D15
HGNC:25694 TBC1D15
KEGG:hsa:64786 TBC1D15
Monarch:64786 TBC1D15
NCBI Entrez Gene:64786 TBC1D15
OMIM:612662 TBC1D15
UCSC:Q8TC07 TBC1D15
Reference Transcript
RefSeq:NM_001146214.1 TBC1D15
RefSeq:NM_022771.4 TBC1D15
RefSeq:NM_001146213.3 TBC1D15
Other Identifiers
11727377_a_at
11727378_at
11757471_s_at
16754208
218268_PM_at
218268_at
230072_PM_at
230072_at
3422327
3422328
3422330
3422333
3422334
3422336
3422338
3422339
3422340
3422341
3422344
3422345
3422346
3422347
3422348
3422349
3422350
3422351
3422354
3422355
3422356
3422357
3422359
3422360
3422361
3422363
3422364
3422367
3422368
3422370
3422371
3422373
3422374
3422375
3422383
3422384
3422385
46955_at
64420_at
64786
70482_at
76716_at
7957186
82931_at
A_14_P137092
A_23_P139558
GE56826
GO:0005096
GO:0005515
GO:0005576
GO:0005737
GO:0043087
GO:0098772
HMNXSV003022168
Hs.146220.0.A1_3p_at
ILMN_1803941
PH_hs_0039971
TC12000628.hg
TC12002446.hg
g12232450_3p_at
This entity regulates
Positively
TBC1D15 accelerates GTP hydrolysis by RAB7
(Homo sapiens)
Inferred To
GYP7 [cytosol]
(Saccharomyces cerevisiae)
Tbc1d15 [cytosol]
(Mus musculus)
Tbc1d15 [cytosol]
(Rattus norvegicus)
tbc-14 [cytosol]
(Caenorhabditis elegans)
gyp7 [cytosol]
(Schizosaccharomyces pombe)
tbc1d15 [cytosol]
(Xenopus tropicalis)
TBC1D15 [cytosol]
(Bos taurus)
TBC1D15 [cytosol]
(Canis familiaris)
TBC1D15 [cytosol]
(Dictyostelium discoideum)
TBC1D15 [cytosol]
(Gallus gallus)
TBC1D15 [cytosol]
(Sus scrofa)
Tbc1d15-17 [cytosol]
(Drosophila melanogaster)
Cross References
RefSeq
NP_001139686.1
,
NP_073608.4
,
NP_001139685.2
ENSEMBL
ENSG00000121749
,
ENSP00000318262
,
ENSP00000448182
,
ENSP00000420678
,
ENST00000550746
,
ENST00000485960
,
ENST00000319106
OpenTargets
ENSG00000121749
GeneCards
TBC1D15
HPA
ENSG00000121749-TBC1D15
PRO
Q8TC07
Pharos - Targets
Q8TC07
GlyGen
Q8TC07
Interactors (32)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96CV9 OPTN
6
p-S177,S473,S513-OPTN [cytosol]
(R-HSA-9687840)
OPTN [cytosol]
(R-HSA-9687907)
p-S177-OPTN [cytosol]
(R-HSA-2562525)
p-S177-OPTN [nucleoplasm]
(R-HSA-2562595)
OPTN [Golgi membrane]
(R-HSA-2161111)
OPTN [recycling endosome membrane]
(R-HSA-8854141)
0.805
9
UniProt:Q96MT8 CEP63
1
CEP63 [cytosol]
(R-HSA-380267)
0.739
5
UniProt:Q8NBM4 UBAC2
0.643
6
UniProt:O95166 GABARAP
3
GABARAP [cytosol]
(R-HSA-975521)
GABARAP(1-117) [cytosol]
(R-HSA-5682696)
GABARAP [autophagosome membrane]
(R-HSA-5683634)
0.591
5
UniProt:Q86VP1 TAX1BP1
1
TAX1BP1 [cytosol]
(R-HSA-937346)
0.556
3
UniProt:Q9P1Z2 CACO1
0.556
3
UniProt:Q96MT8-3 CEP63
0.556
3
UniProt:Q9GZQ8 MAP1LC3B
3
MAP1LC3B [cytosol]
(R-HSA-5205651)
MAP1LC3B(2-121) [cytosol]
(R-HSA-5682674)
MAP1LC3B [autophagosome membrane]
(R-HSA-5683641)
0.544
2
UniProt:Q9H0R8 GABARAPL1
3
GABARAPL1 [cytosol]
(R-HSA-5671757)
GABARAPL1(1-117) [cytosol]
(R-HSA-5682659)
GABARAPL1 [autophagosome membrane]
(R-HSA-5683637)
0.544
2
UniProt:P60520 GABARAPL2
3
GABARAPL2 [cytosol]
(R-HSA-5671758)
GABARAPL2(1-117) [cytosol]
(R-HSA-5682641)
GABARAPL2 [autophagosome membrane]
(R-HSA-5683633)
0.544
2
UniProt:Q9HA65 TBC1D17
1
TBC1D17 [recycling endosome]
(R-HSA-8854149)
0.527
4
UniProt:Q99941 ATF6B
7
ATF6B [endoplasmic reticulum membrane]
(R-HSA-8874179)
ATF6B [Golgi membrane]
(R-HSA-8874154)
ATF6B(2-440) [Golgi membrane]
(R-HSA-8874148)
ATF6B(441-703) [Golgi membrane]
(R-HSA-8874147)
ATF6B(2-398) [cytosol]
(R-HSA-8874143)
ATF6B(399-440) [Golgi membrane]
(R-HSA-8874171)
ATF6B(2-398) [nucleoplasm]
(R-HSA-8874178)
0.527
4
UniProt:Q13304 GPR17
1
GPR17 [plasma membrane]
(R-HSA-416429)
0.527
2
UniProt:P28335 HTR2C
1
HTR2C [plasma membrane]
(R-HSA-390965)
0.527
2
UniProt:Q8WUY1 THEM6
0.527
2
UniProt:B2RTY4 MYO9A
1
MYO9A [cytosol]
(R-HSA-200628)
0.527
3
UniProt:Q8TED0 UTP15
1
UTP15 [nucleoplasm]
(R-HSA-6790678)
0.527
4
UniProt:Q6IC98 GRAM4
0.527
4
UniProt:O00124 UBXN8
0.527
4
UniProt:O43291 SPINT2
1
SPINT2 [extracellular region]
(R-HSA-6800233)
0.527
3
UniProt:P32241 VIPR1
1
VIPR1 [plasma membrane]
(R-HSA-420157)
0.527
2
UniProt:Q6PML9 ZNT9
0.527
4
UniProt:P98153 IDD
0.527
2
UniProt:P50570 DNM2
5
DNM2 [plasma membrane]
(R-HSA-2984201)
DNM2 [lysosomal membrane]
(R-HSA-2980840)
DNM2 [endocytic vesicle membrane]
(R-HSA-2029000)
DNM2 [cytosol]
(R-HSA-2213180)
DNM2 [Golgi membrane]
(R-HSA-2980842)
0.527
4
UniProt:Q86Y82 STX12
0.527
5
UniProt:Q14807 KIF22
1
KIF22 [cytosol]
(R-HSA-984764)
0.527
4
UniProt:P49069 CAMLG
1
CAMLG [endoplasmic reticulum membrane]
(R-HSA-9609522)
0.527
4
UniProt:Q9H1C4 UNC93B1
4
UNC93B1 [Golgi membrane]
(R-HSA-1679064)
UNC93B1 [endoplasmic reticulum membrane]
(R-HSA-1678930)
UNC93B1 P345Pfs*103 [endoplasmic reticulum membrane]
(R-HSA-9628866)
UNC93B1 L230Afs*188 [endoplasmic reticulum membrane]
(R-HSA-9628869)
0.527
2
UniProt:Q9UEU0 VTI1B
2
VTI1B [extracellular region]
(R-HSA-8862983)
VTI1B [platelet alpha granule lumen]
(R-HSA-8862964)
0.527
2
UniProt:Q9H813 PACC1
0.527
2
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.483
6
UniProt:P05919 vpu
6
VPU (P05919) protein [cytosol]
(R-HIV-173223)
VPU (P05919) [endoplasmic reticulum membrane]
(R-HIV-180550)
VPU (P05919) protein [extracellular region]
(R-HIV-175522)
VPU (P05919) protein [nucleoplasm]
(R-HIV-175200)
VPU (P05919) [Golgi membrane]
(R-HIV-3149439)
VPU (P05919) [plasma membrane]
(R-HIV-3149423)
0.462
2
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