TBC1D17 binds OPTN:RAB8A

Stable Identifier
R-HSA-8854182
Type
Reaction
Species
Homo sapiens
Compartment
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Summation

Rab8 is a small GTPase that is specifically involved in the regulation of secretory/recycling vesicles, modulation of the actin cytoskeleton, and cell polarity. TBC (Tre2/Bub2/Cdc16) domain family member 17 (TAB1CD17), a member of the Rab GTPase-activating protein, regulates Rab8-mediated endocytic trafficking of transferrin receptor through its interaction with optineurin (OPTN) (Vaibhava et al. 2012).

Literature References
PubMed ID Title Journal Year
22854040 Optineurin mediates a negative regulation of Rab8 by the GTPase-activating protein TBC1D17

Vaibhava, V, Nagabhushana, A, Chalasani, ML, Sudhakar, C, Kumari, A, Swarup, G

J. Cell. Sci. 2012
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