TBC1D10A binds JFC1

Stable Identifier
R-HSA-8854209
Type
Reaction
Species
Homo sapiens
Compartment
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Summation

TBC1D10A (EPI64) stabilizes active ARF6 and also has an additional function in the ARF6-dependent pathway through regulating the levels of active RAB8A. RAB8A is involved in the recycling pathway from endosomes back to the plasma membrane. TBC1D10A binds the Rab8a effector JFC1 and reduces the level of Rab8a:GTP to regulate Rab8a/Arf6-dependent membrane trafficking. TBC1D10A binds JFC1 through its (Slp) homology domain (SHD), and JFC1 can simultaneously interact with active Rab8a (Hokanson & Bretscher 2011).

Literature References
PubMed ID Title Journal Year
22219378 EPI64 interacts with Slp1/JFC1 to coordinate Rab8a and Arf6 membrane trafficking

Hokanson, DE, Bretscher, AP

Mol. Biol. Cell 2012
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