Reactome: A Curated Pathway Database

'TBC1D15 [cytosol]' positively regulates 'TBC1D15 accelerates GTP hydrolysis by RAB7'

Stable Identifier
R-HSA-8854228
Type
PositiveRegulation
Locations in the PathwayBrowser
Summation

The small GTPase Rab7 promotes fusion events between late endosomes and lysosomes. TBC domain family, member 15 (TAB1CD15) is ubiquitously expressed and localized predominantly to the cytosol. TBC1D15 stimulates the intrinsic GTPase activity of Rab7, reducing Rab7 binding to its effector protein RILP, fragmenting the lysosome, and conferring resistance to growth factor withdrawal-induced cell death (Zhang et al. 2005, Peralta et al. 2010).

Literature References
Regulation participants
Regulation type
PositiveRegulation
Regulator