AURKA Activation by TPX2

Stable Identifier
R-HSA-8854518
Type
Pathway
Species
Homo sapiens
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Summation

TPX2 binds to aurora kinase A (AURKA) at centrosomes and promotes its activation by facilitating AURKA active conformation and autophosphorylation of the AURKA threonine residue T288 (Bayliss et al. 2003, Xu et al. 2011, Giubettini et al. 2011, Dodson and Bayliss 2012).

Literature References
PubMed ID Title Journal Year
21147853 Control of Aurora-A stability through interaction with TPX2

Giubettini, M, Asteriti, IA, Scrofani, J, De Luca, M, Lindon, C, Lavia, P, Guarguaglini, G

J. Cell. Sci. 2011
22094468 Activation of Aurora-A kinase by protein partner binding and phosphorylation are independent and synergistic

Dodson, CA, Bayliss, R

J. Biol. Chem. 2012
14580337 Structural basis of Aurora-A activation by TPX2 at the mitotic spindle

Bayliss, R, Sardon, T, Vernos, I, Conti, E

Mol. Cell 2003
21347367 Two TPX2-dependent switches control the activity of Aurora A

Xu, X, Wang, X, Xiao, Z, Li, Y, Wang, Y

PLoS ONE 2011
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