Reactome: A Curated Pathway Database

Interaction between PHLDA1 and AURKA

Stable Identifier
R-HSA-8854521
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

PHLDA1 (TDAG51), the product of a gene involved in breast cancer progression, interacts with aurora kinase A (AURKA). While unphosphorylated PHLDA1 promotes AURKA ubiquitination and degradation, AURKA-mediated phosphorylation of PHLDA1 results in down-regulation of PHLDA1 protein levels. Ectopic expression of PHLDA1 strongly antagonizes AURKA-triggered oncogenic phenotypes, suggesting PHLDA1 downregulation as one of the key mechanisms by which AURKA promotes breast cancer (Johnson et al. 2011).

Literature References
Participants
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Orthologous Events