Interaction between PHLDA1 and AURKA

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R-HSA-8854521
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Pathway
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Homo sapiens
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PHLDA1 (TDAG51), the product of a gene involved in breast cancer progression, interacts with aurora kinase A (AURKA). While unphosphorylated PHLDA1 promotes AURKA ubiquitination and degradation, AURKA-mediated phosphorylation of PHLDA1 results in down-regulation of PHLDA1 protein levels. Ectopic expression of PHLDA1 strongly antagonizes AURKA-triggered oncogenic phenotypes, suggesting PHLDA1 downregulation as one of the key mechanisms by which AURKA promotes breast cancer (Johnson et al. 2011).

Literature References
PubMed ID Title Journal Year
21807936 PHLDA1 is a crucial negative regulator and effector of Aurora A kinase in breast cancer

Johnson, EO, Chang, KH, de Pablo, Y, Ghosh, S, Mehta, R, Badve, S, Shah, K

J. Cell. Sci. 2011
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