Reactome: A Curated Pathway Database

'TBC1D16 [cytosol]' positively regulates 'TBC1D16 accelerates GTP hydrolysis by RAB4A'

Stable Identifier
R-HSA-8854603
Type
PositiveRegulation
Locations in the PathwayBrowser
Summation

RAB4A is a master regulator of receptor recycling from endocytic compartments to the plasma membrane. It is involved in transferrin receptor recycling and EGFR trafficking and signalling. TBC (Tre2/Bub2/Cdc16) domain family member 16 (TBC1D16), is a GTPase activating protein for Rab4A and enhances the intrinsic rate of GTP hydrolysis by RAB4A (Goueli et al. 2012).

Literature References
PubMed ID Title Journal Year
Regulation participants
Regulation type
PositiveRegulation
Regulator