Positive regulation by 'TBC1D16 [cytosol]'

Stable Identifier
R-HSA-8854603
Type
PositiveRegulation
Locations in the PathwayBrowser
Summation

RAB4A is a master regulator of receptor recycling from endocytic compartments to the plasma membrane. It is involved in transferrin receptor recycling and EGFR trafficking and signalling. TBC (Tre2/Bub2/Cdc16) domain family member 16 (TBC1D16), is a GTPase activating protein for Rab4A and enhances the intrinsic rate of GTP hydrolysis by RAB4A (Goueli et al. 2012).

Literature References
PubMed ID Title Journal Year
23019362 TBC1D16 is a Rab4A GTPase activating protein that regulates receptor recycling and EGF receptor signaling

Goueli, BS, Powell, MB, Finger, EC, Pfeffer, SR

Proc. Natl. Acad. Sci. U.S.A. 2012
Regulation participants
Regulation type
PositiveRegulation
Regulator