'TBC1D16 [cytosol]' positively regulates 'TBC1D16 accelerates GTP hydrolysis by RAB4A'

Stable Identifier
R-HSA-8854603
Type
PositiveRegulation
Locations in the PathwayBrowser
Summation

RAB4A is a master regulator of receptor recycling from endocytic compartments to the plasma membrane. It is involved in transferrin receptor recycling and EGFR trafficking and signalling. TBC (Tre2/Bub2/Cdc16) domain family member 16 (TBC1D16), is a GTPase activating protein for Rab4A and enhances the intrinsic rate of GTP hydrolysis by RAB4A (Goueli et al. 2012).

Literature References
PubMed ID Title Journal Year
23019362 TBC1D16 is a Rab4A GTPase activating protein that regulates receptor recycling and EGF receptor signaling Proc. Natl. Acad. Sci. U.S.A. 2012
Regulation participants
Regulation type
PositiveRegulation
Regulator