TBC1D25 accelerates GTP hydrolysis by RAB33B

Stable Identifier
R-HSA-8854612
Type
Reaction [transition]
Species
Homo sapiens
Compartment
autophagosome membrane
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TBC1D25 accelerates GTP hydrolysis by RAB33B
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RAB33B a medial Golgi-resident Rab involved in retrograde transport, is a target of TBC1D25 (OATL1). TBC1D25 significantly accelerates the GTP hydrolysis activity of RAB33B in a dose-dependent manner (Itoh et al. 2011).

Literature References
PubMed ID Title Journal Year
21383079 OATL1, a novel autophagosome-resident Rab33B-GAP, regulates autophagosomal maturation

Itoh, T, Kanno, E, Uemura, T, Waguri, S, Fukuda, M

J. Cell Biol. 2011
Participants
Input
Output
Participates
as an event of
Catalyst Activity

GTPase activity of RAB33:GTP [Golgi membrane]

Physical Entity
RAB33:GTP [Golgi membrane] (Homo sapiens)
Activity
GTPase activity (GO:0003924)
This event is regulated
Positively by
Regulator
TBC1D25 [autophagosome] (Homo sapiens)
Summation

RAB33B a medial Golgi-resident Rab involved in retrograde transport, is a target of TBC1D25 (OATL1). TBC1D25 significantly accelerates the GTP hydrolysis activity of RAB33B in a dose-dependent manner (Itoh et al. 2011).

Orthologous Events
TBC1D25 accelerates GTP hydrolysis by RAB33B (Bos taurus)
TBC1D25 accelerates GTP hydrolysis by RAB33B (Caenorhabditis elegans)
TBC1D25 accelerates GTP hydrolysis by RAB33B (Canis familiaris)
TBC1D25 accelerates GTP hydrolysis by RAB33B (Danio rerio)
TBC1D25 accelerates GTP hydrolysis by RAB33B (Dictyostelium discoideum)
TBC1D25 accelerates GTP hydrolysis by RAB33B (Gallus gallus)
TBC1D25 accelerates GTP hydrolysis by RAB33B (Mus musculus)
TBC1D25 accelerates GTP hydrolysis by RAB33B (Plasmodium falciparum)
TBC1D25 accelerates GTP hydrolysis by RAB33B (Rattus norvegicus)
TBC1D25 accelerates GTP hydrolysis by RAB33B (Sus scrofa)
Authored
Garapati, P V  (2016-01-27)
Created
Garapati, P V  (2016-01-28)
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