Interleukin-20 family signaling

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R-HSA-8854691
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Homo sapiens
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The interleukin 20 (IL20) subfamily comprises IL19, IL20, IL22, IL24 and IL26. They are members of the larger IL10 family, but have been grouped together based on their usage of common receptor subunits and similarities in their target cell profiles and biological functions. Members of the IL20 subfamily facilitate the communication between leukocytes and epithelial cells, thereby enhancing innate defence mechanisms and tissue repair processes at epithelial surfaces. Much of the understanding of this group of cytokines is based on IL22, which is the most studied member (Rutz et al. 2014, Akdis M et al. 2016, Longsdon et al. 2012).

Literature References
PubMed ID Title Journal Year
27577879 Interleukins (from IL-1 to IL-38), interferons, transforming growth factor β, and TNF-α: Receptors, functions, and roles in diseases

Akdis, M, Aab, A, Altunbulakli, C, Azkur, K, Costa, RA, Crameri, R, Duan, S, Eiwegger, T, Eljaszewicz, A, Ferstl, R, Frei, R, Garbani, M, Globinska, A, Hess, L, Huitema, C, Kubo, T, Komlosi, Z, Konieczna, P, Kovacs, N, Kucuksezer, UC, Meyer, N, Morita, H, Olzhausen, J, O'Mahony, L, Pezer, M, Prati, M, Rebane, A, Rhyner, C, Rinaldi, A, Sokolowska, M, Stanic, B, Sugita, K, Treis, A, Van De Veen, W, Wanke, K, Wawrzyniak, M, Wawrzyniak, P, Wirz, OF, Zakzuk, JS, Akdis, CA

J. Allergy Clin. Immunol. 2016
22802649 Structural basis for receptor sharing and activation by interleukin-20 receptor-2 (IL-20R2) binding cytokines

Logsdon, NJ, Deshpande, A, Harris, BD, Rajashankar, KR, Walter, MR

Proc. Natl. Acad. Sci. U.S.A. 2012
25421700 The IL-20 subfamily of cytokines--from host defence to tissue homeostasis

Rutz, S, Wang, X, Ouyang, W

Nat. Rev. Immunol. 2014
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