TBC1D14 binds RAB11 and ULK1

Stable Identifier
R-HSA-8854759
Type
Reaction
Species
Homo sapiens
Compartment
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Summation

TBC (Tre2/Bub2/Cdc16) domain family, member 14 (TBC1D14) is a putative Rab GTPase activating protein (GAP) member that binds to activated Rab11 and regulates starvation-induced autophagy. TBC1D14 does not have the GAP activity and may function as Rab11 effector. TBC1D14 also colocalizes and interacts with the autophagy kinase ULK1. Overexpression of TBC1D14 causes tubulation of recycling endosomes (REs), accumulation of the ULK1 complex and Rab11 on REs, and inhibition of vesicular transport from the RE (Longatti et al. 2012).

Literature References
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