Reactome | HLTF [nucleoplasm]

HLTF [nucleoplasm]

Stable Identifier

R-HSA-8855007

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Helicase-like transcription factor ecNumber3.6.4.-/ecNumber ecNumber6.3.2.-/ecNumber, HLTF_HUMAN

Locations in the PathwayBrowser for interactor UniProt:P61088

Expand all

External Reference Information

External Reference

UniProt:Q14527 HLTF

Gene Names

HLTF, HIP116A, RNF80, SMARCA3, SNF2L3, ZBU1

Chain

chain:1-1009

Reference Genes

BioGPS Gene:6596 HLTF

COSMIC (genes):HLTF HLTF

CTD Gene:6596 HLTF

dbSNP Gene:6596 HLTF

ENSEMBL:ENSG00000071794 HLTF

ENSEMBL_homo_sapiens_GENE:ENSG00000071794.16 HLTF

HGNC:11099 HLTF

Monarch:6596 HLTF

NCBI Gene:6596 HLTF

OMIM:603257 HLTF

UCSC:Q14527 HLTF

Reference Transcript

Other Identifiers

11717286_a_at

11737098_a_at

16960271

202983_PM_at

202983_at

2700198

2700199

2700200

2700201

2700202

2700203

2700205

2700207

2700209

2700210

2700211

2700212

2700213

2700214

2700215

2700216

2700217

2700218

2700219

2700220

2700221

2700225

2700229

2700230

2700231

2700232

2700233

2700234

2700235

2700237

2700238

34327_at

34328_s_at

6596

8091354

A_24_P277155

GE60408

GO:0000166

GO:0003676

GO:0003677

GO:0003723

GO:0003824

GO:0004386

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005886

GO:0006281

GO:0006325

GO:0006338

GO:0006351

GO:0006355

GO:0008094

GO:0008152

GO:0008270

GO:0016020

GO:0016071

GO:0016363

GO:0016567

GO:0016740

GO:0016787

GO:0016818

GO:0030154

GO:0031625

GO:0036211

GO:0042789

GO:0043226

GO:0045944

GO:0046872

GO:0048856

GO:0050767

GO:0061630

GO:0090575

GO:0140096

GO:0140097

GO:0140657

GO:0140658

HMNXSV003028491

Hs.3068.0.A2_3p_at

ILMN_1673820

ILMN_1798588

ILMN_1856864

L34673_at

PH_hs_0000385

TC03001882.hg

Participates

as an input of

HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Homo sapiens)

as an output of

HLTF polyubiquitinates monoubiquitinated PCNA (Homo sapiens)

as a component of

HLTF:monoUb:K164-PCNA:RAD18:UBE2B:Ub:UBE2N:UBE2V2 [nucleoplasm] (Homo sapiens)

Inferred To

Ghost homologue of HLTF [nucleoplasm] (Danio rerio)

Ghost homologue of HLTF [nucleoplasm] (Dictyostelium discoideum)

Ghost homologue of HLTF [nucleoplasm] (Gallus gallus)

Ghost homologue of HLTF [nucleoplasm] (Plasmodium falciparum)

Ghost homologue of HLTF [nucleoplasm] (Schizosaccharomyces pombe)

HLTF [nucleoplasm] (Bos taurus)

HLTF [nucleoplasm] (Canis familiaris)

HLTF [nucleoplasm] (Mus musculus)

HLTF [nucleoplasm] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_001305864.1, NP_001305863.1, NP_620636.1, XP_016862568.1, NP_003062.2

OpenTargets

ENSG00000071794

GeneCards

Q14527

HPA

ENSG00000071794-HLTF

Ensembl

ENSP00000376644, ENSG00000071794, ENST00000494055, ENST00000392912, ENSP00000308944, ENST00000310053, ENSP00000420429

PRO

Q14527

Pharos - Targets

Q14527

PDB

4S0N, 4XZG, 5K5F, 5BNH, 4XZF, 4HRE, 4HRH, 6KCS, 2MZN

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61088 UBE2N	5	Ub-C87-UBE2N [nucleoplasm] (R-HSA-8943013) Ub-C87-UBE2N [cytosol] (R-HSA-8864210) K63polyUb-C87-UBE2N [nucleoplasm] (R-HSA-6790511) UBE2N [nucleoplasm] (R-HSA-5682541) UBE2N [cytosol] (R-HSA-206072)	0.677	4
UniProt:Q9NS91 RAD18	1	RAD18 [nucleoplasm] (R-HSA-5643731)	0.623	3
UniProt:P12004 PCNA	5	monoSUMO1-K164,K254,K-PCNA [nucleoplasm] (R-HSA-4615861) K63polyUb-K164-PCNA [nucleoplasm] (R-HSA-8943000) ISG-K164,ISG-K168-PCNA [nucleoplasm] (R-HSA-5653768) MonoUb-K164-PCNA [nucleoplasm] (R-HSA-5651986) PCNA [nucleoplasm] (R-HSA-68439)	0.564	2
IntAct:EBI-6871657 B-BOX			0.499	2
UniProt:Q15819 UBE2V2	2	UBE2V2 [cytosol] (R-HSA-947624) UBE2V2 [nucleoplasm] (R-HSA-5682543)	0.462	2