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HLTF [nucleoplasm]
Stable Identifier
R-HSA-8855007
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Helicase-like transcription factor ecNumber3.6.4.-/ecNumber ecNumber6.3.2.-/ecNumber, HLTF_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q15819
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Protein ubiquitination (Homo sapiens)
E3 ubiquitin ligases ubiquitinate target proteins (Homo sapiens)
HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Homo sapiens)
HLTF [nucleoplasm] (Homo sapiens)
HLTF polyubiquitinates monoubiquitinated PCNA (Homo sapiens)
HLTF [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q14527 HLTF
Gene Names
HLTF, HIP116A, RNF80, SMARCA3, SNF2L3, ZBU1
Chain
chain:1-1009
Reference Genes
BioGPS Gene:6596 HLTF
COSMIC (genes):HLTF HLTF
CTD Gene:6596 HLTF
dbSNP Gene:6596 HLTF
ENSEMBL:ENSG00000071794 HLTF
ENSEMBL_homo_sapiens_GENE:ENSG00000071794.16 HLTF
HGNC:11099 HLTF
Monarch:6596 HLTF
NCBI Gene:6596 HLTF
OMIM:603257 HLTF
UCSC:Q14527 HLTF
Reference Transcript
RefSeq:NM_139048.2 HLTF
RefSeq:NM_001318934.1 HLTF
RefSeq:XM_017007079.1 HLTF
RefSeq:NM_003071.3 HLTF
RefSeq:NM_001318935.1 HLTF
Other Identifiers
11717286_a_at
11737098_a_at
16960271
202983_PM_at
202983_at
2700198
2700199
2700200
2700201
2700202
2700203
2700205
2700207
2700209
2700210
2700211
2700212
2700213
2700214
2700215
2700216
2700217
2700218
2700219
2700220
2700221
2700225
2700229
2700230
2700231
2700232
2700233
2700234
2700235
2700237
2700238
34327_at
34328_s_at
6596
8091354
A_24_P277155
GE60408
GO:0000166
GO:0003676
GO:0003677
GO:0003723
GO:0003824
GO:0004386
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0005886
GO:0006281
GO:0006325
GO:0006338
GO:0006351
GO:0006355
GO:0008094
GO:0008152
GO:0008270
GO:0016020
GO:0016071
GO:0016363
GO:0016567
GO:0016740
GO:0016787
GO:0016818
GO:0030154
GO:0031625
GO:0036211
GO:0042789
GO:0043226
GO:0045944
GO:0046872
GO:0048856
GO:0050767
GO:0061630
GO:0090575
GO:0140096
GO:0140097
GO:0140657
GO:0140658
HMNXSV003028491
Hs.3068.0.A2_3p_at
ILMN_1673820
ILMN_1798588
ILMN_1856864
L34673_at
PH_hs_0000385
TC03001882.hg
Participates
as an input of
HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Homo sapiens)
as an output of
HLTF polyubiquitinates monoubiquitinated PCNA (Homo sapiens)
as a component of
HLTF:monoUb:K164-PCNA:RAD18:UBE2B:Ub:UBE2N:UBE2V2 [nucleoplasm] (Homo sapiens)
Inferred To
Ghost homologue of HLTF [nucleoplasm]
(Danio rerio)
Ghost homologue of HLTF [nucleoplasm]
(Dictyostelium discoideum)
Ghost homologue of HLTF [nucleoplasm]
(Gallus gallus)
Ghost homologue of HLTF [nucleoplasm]
(Plasmodium falciparum)
Ghost homologue of HLTF [nucleoplasm]
(Schizosaccharomyces pombe)
HLTF [nucleoplasm]
(Bos taurus)
HLTF [nucleoplasm]
(Canis familiaris)
HLTF [nucleoplasm]
(Mus musculus)
HLTF [nucleoplasm]
(Saccharomyces cerevisiae)
Cross References
RefSeq
NP_001305864.1
,
NP_001305863.1
,
NP_620636.1
,
XP_016862568.1
,
NP_003062.2
OpenTargets
ENSG00000071794
GeneCards
Q14527
HPA
ENSG00000071794-HLTF
Ensembl
ENSP00000376644
,
ENSG00000071794
,
ENST00000494055
,
ENST00000392912
,
ENSP00000308944
,
ENST00000310053
,
ENSP00000420429
PRO
Q14527
Pharos - Targets
Q14527
PDB
4S0N
,
4XZG
,
5K5F
,
5BNH
,
4XZF
,
4HRE
,
4HRH
,
6KCS
,
2MZN
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P61088 UBE2N
5
Ub-C87-UBE2N [nucleoplasm]
(R-HSA-8943013)
Ub-C87-UBE2N [cytosol]
(R-HSA-8864210)
K63polyUb-C87-UBE2N [nucleoplasm]
(R-HSA-6790511)
UBE2N [nucleoplasm]
(R-HSA-5682541)
UBE2N [cytosol]
(R-HSA-206072)
0.677
4
UniProt:Q9NS91 RAD18
1
RAD18 [nucleoplasm]
(R-HSA-5643731)
0.623
3
UniProt:P12004 PCNA
5
monoSUMO1-K164,K254,K-PCNA [nucleoplasm]
(R-HSA-4615861)
K63polyUb-K164-PCNA [nucleoplasm]
(R-HSA-8943000)
ISG-K164,ISG-K168-PCNA [nucleoplasm]
(R-HSA-5653768)
MonoUb-K164-PCNA [nucleoplasm]
(R-HSA-5651986)
PCNA [nucleoplasm]
(R-HSA-68439)
0.564
2
IntAct:EBI-6871657 B-BOX
0.499
2
UniProt:Q15819 UBE2V2
2
UBE2V2 [cytosol]
(R-HSA-947624)
UBE2V2 [nucleoplasm]
(R-HSA-5682543)
0.462
2
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