Reactome: A Curated Pathway Database

SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy

Stable Identifier
R-HSA-8855062
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

SLC25A26 (S-adenosylmethionine mitochondrial carrier protein) associated with the inner mitochondrial membrane mediates the exchange of cytosolic AdoMet (S-adenosylmethionine) for mitochondrial AdoHcy (S-adenosylhomocysteine). The substrate specificity and countertransport function of SLC25A26 were established from studies of liposomes reconstituted with purified protein in vitro (Agrimi et al. 2004). SLC25A26 mutations that disrupt transport activity have been identified in patients with defects of mitochondrial function, consistent with a requirement for AdoMet uptake from the cytosol to support mitochondrial methylation reactions (Kishita et al. 2015).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
S-adenosyl-L-methionine transmembrane transporter activity of SLC25A26 [mitochondrial inner membrane] SLC25A26 [mitochondrial inner membrane] S-adenosyl-L-methionine transmembrane transporter activity (0000095)
Orthologous Events