Reactome | VLDLR binds PCSK9

VLDLR binds PCSK9

Stable Identifier

R-HSA-8855111

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, extracellular region

ReviewStatus

5/5

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Circulating proprotein convertase subtilisin/kexin type 9 (PCSK9) is an important regulator of plasma cholesterol homeostasis by binding to low-density lipid receptor family members and promoting their degradation in lysosomes (Poirier et al. 2008). In mice, it was observed that circulating PCSK9 can regulate VLDLR protein levels in adipose tissue and thereby, fat accumulation. The absence of PCSK9 led to an increase in lipid uptake resulting in adipocyte hypertrophy which was LDLR-independent (Roubtsova et al. 2011). Whether increased fat deposition also occurs in humans lacking functional PCSK9 remains to be elucidated.

Literature References

PubMed ID	Title	Journal	Year
18039658	The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2 Mayer, G, Nimpf, J, Benjannet, S, Poirier, S, Prat, A, Seidah, NG, Bergeron, E, Nassoury, N, Marcinkiewicz, J, Mayer, H	J. Biol. Chem.	2008
21273557	Circulating proprotein convertase subtilisin/kexin 9 (PCSK9) regulates VLDLR protein and triglyceride accumulation in visceral adipose tissue Prat, A, Seidah, NG, Marcinkiewicz, J, Awan, Z, Chamberland, A, Roubtsova, A, Munkonda, MN, Cianflone, K, Lazure, C	Arterioscler. Thromb. Vasc. Biol.	2011