Reactome | VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane

VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane

Stable Identifier

R-HSA-8855130

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

plasma membrane, lysosomal membrane

ReviewStatus

5/5

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VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane

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Once proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to very low-density lipoprotein receptor (VLDLR), the resultant complex is internalised via the canonical clathrin-dependent endocytic machinery. This degradation route that does not require ubiquitination of the cytoplasmic tail of the receptor and does not involve proteasomal or autophagy pathways. The PCSK9:VLDLR:Clathrin-coated vesicle complex translocates from the plasma membrane, via endosomes to the lysosomal membrane where the receptor is degraded (Zhang et al. 2007, Poirier et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
18039658	The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2 Mayer, G, Nimpf, J, Benjannet, S, Poirier, S, Prat, A, Seidah, NG, Bergeron, E, Nassoury, N, Marcinkiewicz, J, Mayer, H	J. Biol. Chem.	2008
17452316	Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation Garuti, R, Hobbs, HH, Horton, JD, Zhao, Z, Cohen, JC, Zhang, DW, McDonald, M, Lagace, TA	J. Biol. Chem.	2007