Reactome | HAUS1 [cytosol]

HAUS1 [cytosol]

Stable Identifier

R-HSA-8855199

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

HAUS augmin-like complex subunit 1, Coiled-coil domain-containing protein 5, Enhancer of invasion-cluster, HEI-C, HEIC, CCDC5, HAUS1_HUMAN

Locations in the PathwayBrowser

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Organelle biogenesis and maintenance (Homo sapiens)

- Cilium Assembly (Homo sapiens)
  - Anchoring of the basal body to the plasma membrane (Homo sapiens)
    - C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        HAUS complex [cytosol] (Homo sapiens)
        
        HAUS1 [cytosol] (Homo sapiens)
      - mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        HAUS complex [cytosol] (Homo sapiens)
        
        HAUS1 [cytosol] (Homo sapiens)
    - C2CD3 binds the mother centriole (Homo sapiens)
      - mother centriole [cytosol] (Homo sapiens)
        
        HAUS complex [cytosol] (Homo sapiens)
        
        HAUS1 [cytosol] (Homo sapiens)
      - mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        HAUS complex [cytosol] (Homo sapiens)
        
        HAUS1 [cytosol] (Homo sapiens)
    - CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Homo sapiens)
      - basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        HAUS complex [cytosol] (Homo sapiens)
        
        HAUS1 [cytosol] (Homo sapiens)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Homo sapiens)
        
        basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        HAUS complex [cytosol] (Homo sapiens)
        
        HAUS1 [cytosol] (Homo sapiens)
    - CP110 and CEP97 dissociate from the centriole (Homo sapiens)
      - basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        HAUS complex [cytosol] (Homo sapiens)
        
        HAUS1 [cytosol] (Homo sapiens)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        HAUS complex [cytosol] (Homo sapiens)
        
        HAUS1 [cytosol] (Homo sapiens)
    - MARK4 binds ODF2 in the centriole (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        HAUS complex [cytosol] (Homo sapiens)
        
        HAUS1 [cytosol] (Homo sapiens)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        HAUS complex [cytosol] (Homo sapiens)
        
        HAUS1 [cytosol] (Homo sapiens)
    - RAB3IP stimulates nucleotide exchange on RAB8A (Homo sapiens)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Homo sapiens)
        
        basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        HAUS complex [cytosol] (Homo sapiens)
        
        HAUS1 [cytosol] (Homo sapiens)
    - Recruitment of transition zone proteins (Homo sapiens)
      - basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        HAUS complex [cytosol] (Homo sapiens)
        
        HAUS1 [cytosol] (Homo sapiens)
      - basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        HAUS complex [cytosol] (Homo sapiens)
        
        HAUS1 [cytosol] (Homo sapiens)
    - The distal appendage proteins recruit TTBK2 (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        HAUS complex [cytosol] (Homo sapiens)
        
        HAUS1 [cytosol] (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        HAUS complex [cytosol] (Homo sapiens)
        
        HAUS1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q96CS2 HAUS1

Gene Names

HAUS1, CCDC5, HEIC

Chain

chain:1-278

Reference Genes

BioGPS Gene:115106 HAUS1

COSMIC (genes):HAUS1 HAUS1

CTD Gene:115106 HAUS1

dbSNP Gene:115106 HAUS1

ENSEMBL:ENSG00000152240 HAUS1

HGNC:25174 HAUS1

KEGG:hsa:115106 HAUS1

Monarch:115106 HAUS1

NCBI Gene:115106 HAUS1

OMIM:608775 HAUS1

UCSC:Q96CS2 HAUS1

Reference Transcript

RefSeq:NM_138443.3 HAUS1

Other Identifiers

115106

11717314_a_at

16852206

225297_PM_at

225297_at

2831629

2831631

2831633

3787006

3787007

3787008

3787009

3787010

3787011

3787012

3787013

3787015

3787016

3787017

3787018

3787019

3787020

3787021

3787022

3787023

3787024

3787025

3787026

3787027

3787028

3787029

3970780

48996_at

8021101

A_23_P413796

GE87374

GO:0000922

GO:0003674

GO:0005515

GO:0005737

GO:0005813

GO:0005815

GO:0005819

GO:0005829

GO:0005856

GO:0005874

GO:0007010

GO:0007098

GO:0010968

GO:0043226

GO:0051225

GO:0051301

GO:0070652

GO:1990498

HMNXSV003006886

Hs.184164.0.S1_3p_at

ILMN_1745946

ILMN_1803471

PH_hs_0030243

PH_hs_0035998

TC18000166.hg

TC18000697.hg

Participates

as a component of

HAUS complex [cytosol] (Homo sapiens)

Inferred To

HAUS1 [cytosol] (Bos taurus)

HAUS1 [cytosol] (Canis familiaris)

HAUS1 [cytosol] (Gallus gallus)

HAUS1 [cytosol] (Sus scrofa)

Haus1 [cytosol] (Mus musculus)

Haus1 [cytosol] (Rattus norvegicus)

haus1 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_612452.1

OpenTargets

ENSG00000152240

ENSEMBL

ENST00000282058, ENSP00000282058

HPA

ENSG00000152240-HAUS1

PRO

Q96CS2

Pharos - Targets

Q96CS2

PDB

7SQK

Interactors (28)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P11532 DMD	1	DMD [cytosol] (R-HSA-390567)	0.742	5
UniProt:Q8IY31 IFT20	3	IFT20 [ciliary tip] (R-HSA-5625355) IFT20 [Golgi membrane] (R-HSA-5617625) IFT20 [cilium] (R-HSA-5617624)	0.666	7
UniProt:A1L190 SYCE3	1	SYCE3 [nucleoplasm] (R-HSA-8867779)	0.666	4
UniProt:Q9NPJ6 MED4	1	MED4 [nucleoplasm] (R-HSA-350263)	0.659	4
UniProt:Q8N0S2 SYCE1	1	SYCE1 [nucleoplasm] (R-HSA-912456)	0.556	3
UniProt:O14964 HGS	2	HGS [cytosol] (R-HSA-182954) HGS [phagocytic vesicle lumen] (R-HSA-9635660)	0.556	3
UniProt:Q9Y2I6 NINL	2	p-NINL [cytosol] (R-HSA-380716) NINL [cytosol] (R-HSA-380706)	0.556	3
UniProt:Q9UBB9 TFIP11	1	TFIP11 [nucleoplasm] (R-HSA-8869310)	0.556	3
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3
UniProt:P53365 ARFIP2	1	ARFIP2 [cytosol] (R-HSA-6813848)	0.556	3
UniProt:Q99757 TXN2	2	TXN2 [mitochondrial matrix] (R-HSA-3323048) 2xHC-TXN2 [mitochondrial matrix] (R-HSA-3323059)	0.556	3
UniProt:Q15561 TEAD4	1	TEAD4 [nucleoplasm] (R-HSA-2032780)	0.556	3
UniProt:Q14957 GRIN2C	3	GRIN2C [plasma membrane] (R-HSA-419560) GRIN2C [endoplasmic reticulum membrane] (R-HSA-9609761) p-Y-GRIN2C [plasma membrane] (R-HSA-9612189)	0.556	3
UniProt:Q96EV8 DTNBP1	1	DTNBP1 [cytosol] (R-HSA-429819)	0.556	3
UniProt:P14373 TRIM27	2	TRIM27 [cytosol] (R-HSA-8851002) TRIM27 [nucleoplasm] (R-HSA-2997690)	0.556	3
UniProt:Q13077 TRAF1	3	TRAF1 [cytosol] (R-HSA-5634163) TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.556	3
UniProt:Q9Y6D9 MAD1L1	1	MAD1L1 [cytosol] (R-HSA-141433)	0.556	3
UniProt:Q16512 PKN1	3	p-T774-PKN1 [cytosol] (R-HSA-5623651) PKN1 [cytosol] (R-HSA-5623613) p-T774-PKN1 [nucleoplasm] (R-HSA-5625721)	0.556	3
UniProt:Q9UL45 BLOC1S6	1	BLOC1S6 [cytosol] (R-HSA-429816)	0.556	3
UniProt:A1L4H1 SSC5D	1	SSC5D [extracellular region] (R-HSA-8878615)	0.556	3
UniProt:O14879 IFIT3	1	IFIT3 [cytosol] (R-HSA-947491)	0.556	3
UniProt:P06396 GSN	7	GSN [cytosol] (R-HSA-350275) GSN(28-403) [cytosol] (R-HSA-201618) GSN(404-782) [cytosol] (R-HSA-350272) GSN [secretory granule lumen] (R-HSA-6801486) GSN [extracellular region] (R-HSA-6806510) GSN [ficolin-1-rich granule lumen] (R-HSA-6801465) GSN(200-270) [extracellular region] (R-HSA-976940)	0.556	3
UniProt:O15155 BET1	3	BET1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688142) BET1 [transport vesicle] (R-HSA-6808719) BET1 [Golgi membrane] (R-HSA-6807743)	0.527	2
UniProt:Q9P031 CCDC59	1	CCDC59 [nucleoplasm] (R-HSA-5683813)	0.527	3
UniProt:O75528 TADA3	1	TADA3 [nucleoplasm] (R-HSA-3322966)	0.527	2
UniProt:Q92626 PXDN	1	PXDN [extracellular region] (R-HSA-2559628)	0.527	2
UniProt:Q12981 BNIP1	1	BNIP1 [endoplasmic reticulum membrane] (R-HSA-6810950)	0.527	3
UniProt:O60341 KDM1A	1	KDM1A [nucleoplasm] (R-HSA-996769)	0.508	2

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