PTPN22 dephosphorylates ZAP70

Stable Identifier
R-HSA-8855381
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Protein tyrosine phosphatase PTPN22 (LYP, PEP) dephosphorylates ZAP70 adaptor protein on tyrosine residue Y493, resulting in reduced activation of ZAP70. Dephosphorylation of ZAP70 contributes to PTPN22-mediated downregulation of TCR signaling (Wu et al. 2006).

Literature References
PubMed ID Title Journal Year
16461343 Identification of substrates of human protein-tyrosine phosphatase PTPN22

Wu, J, Katrekar, A, Honigberg, LA, Smith, AM, Conn, MT, Tang, J, Jeffery, D, Mortara, K, Sampang, J, Williams, SR, Buggy, J, Clark, JM

J. Biol. Chem. 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine phosphatase activity of PTPN22 [cytosol]
Physical Entity
Activity
Orthologous Events
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