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2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP

Stable Identifier
R-HSA-8855747
Type
Reaction
Species
Homo sapiens
Compartment
extracellular region, plasma membrane, cytosol
Locations in the PathwayBrowser
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Summation

RET phospho-Tyr981 binds the cytoplasmic tyrosine kinase SRC (Encinas et al. 2004). Recently, a yeast-two-hybrid screen led to the identification of the GTPase-activating protein (GAP) for Rap1, RAP1GAP, as a novel RET-binding protein (Jiao et al. 2011). Like SRC, Rap1GAP was also found to require phosphorylation of Tyrosine-981 for RET binding and suppressed GDNF-induced activation of ERK and neurite outgrowth.

Literature References
Participants
Input
Output
Participant Of
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Orthologous Events
2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP (Bos taurus)
2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP (Canis familiaris)
2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP (Danio rerio)
2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP (Gallus gallus)
2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP (Mus musculus)
2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP (Rattus norvegicus)
2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP (Sus scrofa)
2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP (Taeniopygia guttata)
2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP (Xenopus tropicalis)