Reactome | 2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP

2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP

Stable Identifier

R-HSA-8855747

Type

Reaction

Species

Homo sapiens

Compartment

extracellular region, plasma membrane, cytosol

Locations in the PathwayBrowser

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Summation

RET phospho-Tyr981 binds the cytoplasmic tyrosine kinase SRC (Encinas et al. 2004). Recently, a yeast-two-hybrid screen led to the identification of the GTPase-activating protein (GAP) for Rap1, RAP1GAP, as a novel RET-binding protein (Jiao et al. 2011). Like SRC, Rap1GAP was also found to require phosphorylation of Tyrosine-981 for RET binding and suppressed GDNF-induced activation of ERK and neurite outgrowth.

Literature References

PubMed ID	Title	Journal	Year
14766744	Tyrosine 981, a novel ret autophosphorylation site, binds c-Src to mediate neuronal survival Encinas, M, Crowder, RJ, Milbrandt, J, Johnson, EM	J. Biol. Chem.	2004