2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP

Stable Identifier
R-HSA-8855747
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, extracellular region, plasma membrane
ReviewStatus
5/5
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2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP
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RET phospho-Tyr981 binds the cytoplasmic tyrosine kinase SRC (Encinas et al. 2004). Recently, a yeast-two-hybrid screen led to the identification of the GTPase-activating protein (GAP) for Rap1, RAP1GAP, as a novel RET-binding protein (Jiao et al. 2011). Like SRC, Rap1GAP was also found to require phosphorylation of Tyrosine-981 for RET binding and suppressed GDNF-induced activation of ERK and neurite outgrowth.
Literature References
PubMed ID Title Journal Year
14766744 Tyrosine 981, a novel ret autophosphorylation site, binds c-Src to mediate neuronal survival

Crowder, RJ, Milbrandt, J, Johnson, EM, Encinas, M

J. Biol. Chem. 2004
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Orthologous Events
2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP (Bos taurus)
2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP (Canis familiaris)
2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP (Gallus gallus)
2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP (Mus musculus)
2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP (Rattus norvegicus)
2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP (Sus scrofa)
Authored
Jupe, S  (2016-01-25)
Reviewed
Luo, W  (2016-05-17)
Morales, D  (2016-05-06)
Created
Jupe, S  (2016-02-05)
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