HTRA1 hydrolyzes ACAN (Aggrecan)

Stable Identifier
R-HSA-8855825
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Extracellular HTRA1 (High-temperature requirement A serine peptidase 1) catalyzes the hydrolysis of a specific peptide bond in ACAN (Aggrecan) (Chamberland et al. 2009; Hu et al. 1998). The enzyme is a homotrimer (Truebestein et al. 2011). HTRA1 is thereby implicated in the degradation of extracellular matrix. Indirect studies in mouse model systems (e.g., Oka et al. 2004) that HTRA1 may modulate the activity of Tgf-beta and thereby play additional roles, not annotated here, in the turnover of extracellular matrix both normally and during inflammation.

Literature References
PubMed ID Title Journal Year
14973287 HtrA1 serine protease inhibits signaling mediated by Tgfbeta family proteins

Oka, C, Tsujimoto, R, Kajikawa, M, Koshiba-Takeuchi, K, Ina, J, Yano, M, Tsuchiya, A, Ueta, Y, Soma, A, Kanda, H, Matsumoto, M, Kawaichi, M

Development 2004
21297635 Substrate-induced remodeling of the active site regulates human HTRA1 activity

Truebestein, L, Tennstaedt, A, Mönig, T, Krojer, T, Canellas, F, Kaiser, M, Clausen, T, Ehrmann, M

Nat. Struct. Mol. Biol. 2011
9852107 Human HtrA, an evolutionarily conserved serine protease identified as a differentially expressed gene product in osteoarthritic cartilage

Hu, SI, Carozza, M, Klein, M, Nantermet, P, Luk, D, Crowl, RM

J. Biol. Chem. 1998
19657146 Identification of a novel HtrA1-susceptible cleavage site in human aggrecan: evidence for the involvement of HtrA1 in aggrecan proteolysis in vivo

Chamberland, A, Wang, E, Jones, AR, Collins-Racie, LA, LaVallie, ER, Huang, Y, Liu, L, Morris, EA, Flannery, CR, Yang, Z

J. Biol. Chem. 2009
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase activity of HTRA1 trimer [extracellular region]
Physical Entity
Activity
Orthologous Events
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