Reactome | 2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors

2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors

Stable Identifier

R-HSA-8855915

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, extracellular region, plasma membrane

ReviewStatus

5/5

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2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors

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Other RET interactors that may have a role in RET signaling include Mitogen-activated protein kinase 7 (MAPK7, BMK1) (Hayashi et al. 2001), SH3 and multiple ankyrin repeat domains protein 3 (SHANK3) (Schuetz et al. 2004), Insulin receptor substrate-2 (IRS2) (Hennige et al. 2000), SHC-transforming protein 3 (SHC3) (Pelicci et al. 2002), Protein kinase C alpha (PKCA) (Andreozzi et al. 2003) and PDZ and LIM domain protein 7 (Enigma, PDLIM7) (Durick et al. 1996). PDLIM7 and SHANK3 bind Tyrosine-1062 regardless of its phosphorylation state.

Literature References

PubMed ID	Title	Journal	Year
8662982	Mitogenic signaling by Ret/ptc2 requires association with enigma via a LIM domain Gill, GN, Taylor, SS, Wu, RY, Durick, K	J. Biol. Chem.	1996
11237712	Activation of BMK1 via tyrosine 1062 in RET by GDNF and MEN2A mutation Kato, Y, Hayashi, Y, Kurokawa, K, Takahashi, M, Murakamai, H, Ueda, M, Kawai, K, Iwashita, T, Tohnai, I	Biochem. Biophys. Res. Commun.	2001
14766744	Tyrosine 981, a novel ret autophosphorylation site, binds c-Src to mediate neuronal survival Crowder, RJ, Milbrandt, J, Johnson, EM, Encinas, M	J. Biol. Chem.	2004
15569713	The neuronal scaffold protein Shank3 mediates signaling and biological function of the receptor tyrosine kinase Ret in epithelial cells Gundelfinger, ED, Schuetz, G, Boeckers, TM, Birchmeier, W, Grimm, J, Rosário, M	J. Cell Biol.	2004
11000521	Ret oncogene signal transduction via a IRS-2/PI 3-kinase/PKB and a SHC/Grb-2 dependent pathway: possible implication for transforming activity in NIH3T3 cells Strack, V, Seif, FJ, Arlt, D, Kellerer, M, Lammers, R, Hennige, AM, Niederfellner, G, Höppner, W, Häring, HU	Mol. Cell. Endocrinol.	2000
12771945	Protein kinase Calpha activation by RET: evidence for a negative feedback mechanism controlling RET tyrosine kinase Castellone, MD, Carlomagno, F, Formisano, P, Andreozzi, F, Fiory, F, Oriente, F, Beguinot, F, Santopietro, S, Melillo, RM, Miele, C, Santoro, M	Oncogene	2003
12242309	The neuron-specific Rai (ShcC) adaptor protein inhibits apoptosis by coupling Ret to the phosphatidylinositol 3-kinase/Akt signaling pathway De Giuseppe, A, Coda, L, Troglio, F, Melillo, RM, Pettirossi, V, Pelicci, G, Pelicci, PG, Santoro, M, Bodini, A	Mol. Cell. Biol.	2002