Reactome: A Curated Pathway Database

TNFSF8 binds TNFRSF8

Stable Identifier
R-HSA-8856189
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
CD30L binds CD30, CD153 binds CD30
Locations in the PathwayBrowser
Summation

Tumor necrosis factor receptor superfamily 8 (TNFRSF8, CD30) and its ligand TNFSF8 (CD30 ligand, CD30L, CD153) are interacting cell-surface glycoproteins. TNFRSF8 is expressed on activated CD4 and CD8 T cells and B cells. It is a marker for Hodgkin's syndrome. TNFRSF8 signaling regulates hymocyte survival (Blazar et al. 2004) and peripheral T cell responses, controlling T cell survival and down-regulating cytolytic capacity (Duckett et al. 1997, Kurts et al. 1999, Telford et al. 1997).

Literature References
PubMed ID Title Journal Year
8871664 Reverse signaling via CD30 ligand J. Immunol. 1996
Participants
Participant Of
Orthologous Events