Tumor necrosis factor receptor superfamily 8 (TNFRSF8, CD30) and its ligand TNFSF8 (CD30 ligand, CD30L, CD153) are interacting cell-surface glycoproteins. TNFRSF8 is expressed on activated CD4 and CD8 T cells and B cells. It is a marker for Hodgkin's syndrome. TNFRSF8 signaling regulates hymocyte survival (Blazar et al. 2004) and peripheral T cell responses, controlling T cell survival and down-regulating cytolytic capacity (Duckett et al. 1997, Kurts et al. 1999, Telford et al. 1997).