Reactome | NPTN [plasma membrane]

NPTN [plasma membrane]

Stable Identifier

R-HSA-8856422

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Neuroplastin, NPTN_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q9NU22 MDN1

Expand all

External Reference Information

External Reference

UniProt:Q9Y639 NPTN

Gene Names

NPTN, SDFR1, SDR1

Chain

signal peptide:1-28, chain:29-398

Reference Genes

BioGPS Gene:27020 NPTN

COSMIC (genes):NPTN NPTN

CTD Gene:27020 NPTN

dbSNP Gene:27020 NPTN

ENSEMBL:ENSG00000156642 NPTN

HGNC:17867 NPTN

KEGG:hsa:27020 NPTN

Monarch:27020 NPTN

NCBI Gene:27020 NPTN

OMIM:612820 NPTN

UCSC:Q9Y639 NPTN

Reference Transcript

Participates

as a component of

GABR heteropentamers:GABA:NPTN [plasma membrane] (Homo sapiens)

as an input of

NPTN binds GABA A receptors (Homo sapiens)

Cross References

RefSeq

NP_001154835.1, NP_001154836.1, NP_036560.1, NP_059429.1

OpenTargets

ENSG00000156642

ENSEMBL

ENSP00000342958, ENST00000345330, ENSP00000290401, ENST00000563691, ENSP00000457028, ENSG00000156642, ENST00000562924, ENSP00000456349, ENST00000351217

GeneCards

NPTN

HPA

ENSG00000156642-NPTN

PRO

Q9Y639

Pharos - Targets

Q9Y639

GlyGen

Q9Y639

PDB

6A69

Interactors (62)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P20020 ATP2B1	1	ATP2B1 [plasma membrane] (R-HSA-418301)	0.643	4
UniProt:Q9BPY3 F118B			0.527	2
UniProt:O75691 UTP20	1	UTP20 [nucleoplasm] (R-HSA-6790692)	0.527	2
UniProt:Q96Q15 SMG1	1	SMG1 [cytosol] (R-HSA-927760)	0.527	2
UniProt:O00214 LEG8			0.527	2
UniProt:Q9NU22 MDN1			0.527	3
UniProt:Q8ND04 SMG8	1	SMG8 [cytosol] (R-HSA-927759)	0.527	2
UniProt:Q6XUX3 DUSTY			0.527	2
UniProt:Q14746 COG2	2	COG2 [trans-Golgi network membrane] (R-HSA-6813863) COG2 [Golgi membrane] (R-HSA-5216080)	0.527	2
UniProt:O15228 GNPAT	3	GNPAT [cytosol] (R-HSA-9033129) GNPAT [peroxisomal membrane] (R-HSA-1500605) GNPAT [peroxisomal matrix] (R-HSA-53413)	0.527	2
UniProt:Q08AM6 VAC14	3	VAC14 [Golgi membrane] (R-HSA-1806235) VAC14 [early endosome membrane] (R-HSA-1806207) VAC14 [late endosome membrane] (R-HSA-1806219)	0.527	2
UniProt:Q9UPT5 EXOC7	2	EXOC7 [plasma membrane] (R-HSA-2872288) EXOC7 [cytosol] (R-HSA-5623386)	0.527	2
UniProt:Q13535 ATR	1	ATR [nucleoplasm] (R-HSA-912443)	0.527	3
UniProt:Q8NDA8 MROH1			0.527	2
UniProt:Q9H9E3 COG4	2	COG4 [trans-Golgi network membrane] (R-HSA-6813868) COG4 [Golgi membrane] (R-HSA-6808722)	0.527	2
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.527	2
UniProt:Q6NUQ1 RINT1	1	RINT1 [cytosol] (R-HSA-6810991)	0.527	2
UniProt:P42345 MTOR	2	MTOR [cytosol] (R-HSA-165662) MTOR [nucleoplasm] (R-HSA-5083674)	0.527	3
UniProt:Q8NBN3 TMEM87A	1	TMEM87A [endoplasmic reticulum membrane] (R-HSA-9714348)	0.527	2
UniProt:Q7L8W6 DPH6	1	DPH6 [cytosol] (R-HSA-5358469)	0.527	2
UniProt:Q5JPH6 EARS2	1	EARS2 [mitochondrial matrix] (R-HSA-379623)	0.527	3
UniProt:Q9Y394 DHRS7			0.527	3
UniProt:Q9NWZ5 UCKL1	1	UCKL1 [cytosol] (R-HSA-8954322)	0.527	2
UniProt:Q9C0E2 XPO4			0.527	3
UniProt:O14787 TNPO2			0.527	3
UniProt:Q8WXA3 RUFY2			0.527	2
UniProt:O14981 BTAF1			0.527	2
UniProt:Q86Y56 DAAF5			0.527	2
UniProt:Q9BXW9 FANCD2	3	MonoUb-K561,p-T691,S717-FANCD2 [nucleoplasm] (R-HSA-6785318) p-T691,S717-FANCD2 [nucleoplasm] (R-HSA-6788481) FANCD2 [nucleoplasm] (R-HSA-419522)	0.527	3
UniProt:Q8N5B7 CERS5	1	CERS5 [endoplasmic reticulum membrane] (R-HSA-428168)	0.527	2
UniProt:P50748 KNTC1	1	KNTC1 [cytosol] (R-HSA-376233)	0.527	2
UniProt:O43929 ORC4	1	ORC4 [nucleoplasm] (R-HSA-68519)	0.527	2
UniProt:Q6ZS30 NBEL1			0.527	2
UniProt:O15360 FANCA	2	FANCA [nucleoplasm] (R-HSA-419541) FANCA [cytosol] (R-HSA-420796)	0.527	2
UniProt:Q9UIA9 XPO7			0.527	3
UniProt:Q969Z0 TBRG4	1	TBRG4 [mitochondrial matrix] (R-HSA-9837166)	0.527	3
UniProt:P83436 COG7	2	COG7 [trans-Golgi network membrane] (R-HSA-6813873) COG7 [Golgi membrane] (R-HSA-6808726)	0.527	2
UniProt:Q9UJX6 ANAPC2	2	ANAPC2 [cytosol] (R-HSA-174229) ANAPC2 [nucleoplasm] (R-HSA-174141)	0.527	2
UniProt:Q96QU8 XPO6			0.527	2
UniProt:Q13315 ATM	5	ATM [cytosol] (R-HSA-9665171) ATM [peroxisomal matrix] (R-HSA-9665169) p-S1981,Ac-K3016-ATM [nucleoplasm] (R-HSA-5693527) ATM [nucleoplasm] (R-HSA-69484) Ac-K3016-ATM [nucleoplasm] (R-HSA-5682043)	0.527	2
UniProt:P23634 ATP2B4	1	ATP2B4 [plasma membrane] (R-HSA-418304)	0.527	3
UniProt:Q6NXR4 TTI2			0.527	3
UniProt:Q9UID3 VPS51	1	VPS51 [trans-Golgi network membrane] (R-HSA-6811027)	0.527	3
UniProt:Q53R41 FAKD1			0.527	2
UniProt:Q6ZNJ1 NBEAL2	3	NBEAL2 [ficolin-1-rich granule membrane] (R-HSA-6801027) NBEAL2 [plasma membrane] (R-HSA-6806439) NBEAL2 [tertiary granule membrane] (R-HSA-6800409)	0.527	2
UniProt:Q8TCG1 CIP2A			0.527	2
UniProt:Q9BTW9 TBCD	1	TBCD [cytosol] (R-HSA-379540)	0.527	3
UniProt:Q8TAG9 EXOC6	2	EXOC6 [plasma membrane] (R-HSA-265041) EXOC6 [cytosol] (R-HSA-5623384)	0.527	2
UniProt:Q29RF7 PDS5A	4	PDS5A [nucleoplasm] (R-HSA-2468043) PDS5A [chromosome, centromeric region] (R-HSA-2468259) PDS5A [chromosome] (R-HSA-2466360) PDS5A [cytosol] (R-HSA-2484799)	0.527	3
UniProt:O00471 EXOC5	2	EXOC5 [cytosol] (R-HSA-265045) EXOC5 [cytosol] (R-HSA-5623383)	0.527	2
UniProt:Q96JB2 COG3	2	COG3 [trans-Golgi network membrane] (R-HSA-6813865) COG3 [Golgi membrane] (R-HSA-5216030)	0.527	3
UniProt:O43264 ZW10	1	ZW10 [cytosol] (R-HSA-377880)	0.527	2
UniProt:Q9Y5X3 SNX5	2	SNX5 [Golgi membrane] (R-HSA-434336) SNX5 [cytoplasmic vesicle membrane] (R-HSA-434207)	0.527	2
UniProt:Q9UPU5 USP24	1	USP24 [nucleoplasm] (R-HSA-5697004)	0.527	2
UniProt:Q9UP83 COG5	2	COG5 [trans-Golgi network membrane] (R-HSA-6813869) COG5 [Golgi membrane] (R-HSA-6808725)	0.527	2
UniProt:Q9Y2V7 COG6	2	COG6 [Golgi membrane] (R-HSA-2980958) COG6 [trans-Golgi network membrane] (R-HSA-6813872)	0.527	2
UniProt:Q9UI26 IPO11			0.527	3
UniProt:Q9BW27 NUP85	2	NUP85 [nuclear envelope] (R-HSA-157741) NUP85 [cytosol] (R-HSA-376238)	0.527	3
UniProt:O43301 HSPA12A	2	HSPA12A [cytosol] (R-HSA-5252017) HSPA12A [nucleoplasm] (R-HSA-5252130)	0.527	2
UniProt:Q9Y4R8 TELO2			0.527	3
UniProt:Q96MW5 COG8	2	COG8 [trans-Golgi network membrane] (R-HSA-6813875) COG8 [Golgi membrane] (R-HSA-6808728)	0.527	2
UniProt:Q8WTW3 COG1	2	COG1 [trans-Golgi network membrane] (R-HSA-6813862) COG1 [Golgi membrane] (R-HSA-6808721)	0.527	3

Cite Us!