Angiopoietin-like proteins (ANGPTLs) play major roles in the trafficking and metabolism of lipids. Angiopoietin-like protein 8 (ANGPTL8, aka betatrophin, lipasin) can regulate ANGPTL3 by binding to and promoting cleavage of it, thereby further activating ANGPTL3 (a protein that plays a critical role in the regulation of triglyceride and cholesterol plasma levels, via reversible inhibition of lipoprotein lipase activity) (Ren et al. 2012, Quagliarini et al. 2012, Li & Teng 2014). The exact mechanism of action of ANGPTL8 on ANGPTL3 is poorly understood.
Li, Y, Teng, C
Ren, G, Kim, JY, Smas, CM
Quagliarini, F, Wang, Y, Kozlitina, J, Grishin, NV, Hyde, R, Boerwinkle, E, Valenzuela, DM, Murphy, AJ, Cohen, JC, Hobbs, HH
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