ANGPTL8 binds ANGPTL3

Stable Identifier
R-HSA-8856525
Type
Reaction [binding]
Species
Homo sapiens
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Angiopoietin-like proteins (ANGPTLs) play major roles in the trafficking and metabolism of lipids. Angiopoietin-like protein 8 (ANGPTL8, aka betatrophin, lipasin) can regulate ANGPTL3 by binding to and promoting cleavage of it, thereby further activating ANGPTL3 (a protein that plays a critical role in the regulation of triglyceride and cholesterol plasma levels, via reversible inhibition of lipoprotein lipase activity) (Ren et al. 2012, Quagliarini et al. 2012, Li & Teng 2014). The exact mechanism of action of ANGPTL8 on ANGPTL3 is poorly understood.

Literature References
PubMed ID Title Journal Year
24960069 Angiopoietin-like proteins 3, 4 and 8: regulating lipid metabolism and providing new hope for metabolic syndrome

Li, Y, Teng, C

J Drug Target 2014
22569073 Identification of RIFL, a novel adipocyte-enriched insulin target gene with a role in lipid metabolism

Ren, G, Kim, JY, Smas, CM

Am. J. Physiol. Endocrinol. Metab. 2012
23150577 Atypical angiopoietin-like protein that regulates ANGPTL3

Quagliarini, F, Wang, Y, Kozlitina, J, Grishin, NV, Hyde, R, Boerwinkle, E, Valenzuela, DM, Murphy, AJ, Cohen, JC, Hobbs, HH

Proc. Natl. Acad. Sci. U.S.A. 2012
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