CIDEA:CIDEC binds lipid droplets

Stable Identifier
R-HSA-8856630
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Humans possess three cell death-inducing DFFA-like effector (CIDE) proteins, CIDEA, CIDEB and CIDEC. Initially, their function was determined to be the promotion of apoptosis but they are also known to play a role in energy metabolism. CIDEA and C bind to lipid droplets and regulate their enlargement, thereby restricting lipolysis and favouring storage (by promoting net neutral lipid transfer from smaller to larger lipid droplets) (for review see Gao & Goodman 2015). CIDEA is bound to CIDEC to form a heterodimer (Liu et al. 2009). CIDEB has not been determined to bind lipid droplets.
Literature References
PubMed ID Title Journal Year
19843876 Functional analysis of FSP27 protein regions for lipid droplet localization, caspase-dependent apoptosis, and dimerization with CIDEA

Zhou, S, Majors, D, Rearick, D, Barricklow, K, Kim, JY, Houston, MS, Fernandez-Boyanapalli, RF, Smas, CM, Liu, K, Lee, JH, Tillison, K

Am. J. Physiol. Endocrinol. Metab. 2009
26322308 The lipid droplet-a well-connected organelle

Goodman, JM, Gao, Q

Front Cell Dev Biol 2015
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