Golgi-to-ER retrograde transport

Stable Identifier
R-HSA-8856688
Type
Pathway
Species
Homo sapiens
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Retrograde traffic from the cis-Golgi to the ERGIC or the ER occurs through either COPI-coated vesicles or through a less well characterized RAB6-dependent route that makes use of tubular carriers (reviewed in Lord et al, 2013; Spang et al, 2013; Heffernan and Simpson, 2014). The balance between these two pathways may be influenced cargo type and concentration and membrane composition, though the details remain to be worked out (reviewed in Heffernan and Simpson, 2014).

Literature References
PubMed ID Title Journal Year
23378591 The highly conserved COPII coat complex sorts cargo from the endoplasmic reticulum and targets it to the golgi

Lord, C, Ferro-Novick, S, Miller, EA

Cold Spring Harb Perspect Biol 2013
23732476 Retrograde traffic from the Golgi to the endoplasmic reticulum

Spang, A

Cold Spring Harb Perspect Biol 2013
25233431 The trials and tubule-ations of Rab6 involvement in Golgi-to-ER retrograde transport

Heffernan, LF, Simpson, JC

Biochem. Soc. Trans. 2014
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