Reactome | CLTC [cytosol]

CLTC [cytosol]

Stable Identifier

R-HSA-8856820

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Clathrin heavy chain 1, CLH1_HUMAN, CLH17, CLTCL2, KIAA0034

Locations in the PathwayBrowser

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Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Clathrin-mediated endocytosis (Homo sapiens)
    - AAK1 phosphorylates AP-2 mu subunit at T156 (Homo sapiens)
      - PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:AP-2:clathrin [plasma membrane] (Homo sapiens)
        
        clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTC [cytosol] (Homo sapiens)
        
        clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTC [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
        
        clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTC [cytosol] (Homo sapiens)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        Clathrin-coated vesicle [cytosol] (Homo sapiens)
        
        clathrin [cytosol] (Homo sapiens)
        
        CLTC [cytosol] (Homo sapiens)
        
        clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTC [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        Clathrin-coated vesicle [cytosol] (Homo sapiens)
        
        clathrin [cytosol] (Homo sapiens)
        
        CLTC [cytosol] (Homo sapiens)
        
        clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTC [cytosol] (Homo sapiens)
    - BAR domain proteins recruit dynamin (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTC [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTC [cytosol] (Homo sapiens)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
        
        clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTC [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
        
        clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTC [cytosol] (Homo sapiens)
    - Cargo recognition for clathrin-mediated endocytosis (Homo sapiens)
      - ARBB recruits GPCRs into clathrin-coated pits (Homo sapiens)
        
        ARBBs:ARBB-binding GPCRs:clathrin-coated pit [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
        
        clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTC [cytosol] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
        
        clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTC [cytosol] (Homo sapiens)
    - Clathrin recruits PIK3C2A (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
        
        clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTC [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
        
        clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTC [cytosol] (Homo sapiens)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        Clathrin-coated vesicle [cytosol] (Homo sapiens)
        
        clathrin [cytosol] (Homo sapiens)
        
        CLTC [cytosol] (Homo sapiens)
        
        clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTC [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        Clathrin-coated vesicle [cytosol] (Homo sapiens)
        
        clathrin [cytosol] (Homo sapiens)
        
        CLTC [cytosol] (Homo sapiens)
        
        clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTC [cytosol] (Homo sapiens)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
        
        clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTC [cytosol] (Homo sapiens)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        Clathrin-coated vesicle [cytosol] (Homo sapiens)
        
        clathrin [cytosol] (Homo sapiens)
        
        CLTC [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        Clathrin-coated vesicle [cytosol] (Homo sapiens)
        
        clathrin [cytosol] (Homo sapiens)
        
        CLTC [cytosol] (Homo sapiens)
    - Dissociation of clathrin-associated proteins (Homo sapiens)
      - CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        Clathrin-coated vesicle [cytosol] (Homo sapiens)
        
        clathrin [cytosol] (Homo sapiens)
        
        CLTC [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        Clathrin-coated vesicle [cytosol] (Homo sapiens)
        
        clathrin [cytosol] (Homo sapiens)
        
        CLTC [cytosol] (Homo sapiens)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        Clathrin-coated vesicle [cytosol] (Homo sapiens)
        
        clathrin [cytosol] (Homo sapiens)
        
        CLTC [cytosol] (Homo sapiens)
        
        clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTC [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTC [cytosol] (Homo sapiens)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTC [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTC [cytosol] (Homo sapiens)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
        
        clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTC [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTC [cytosol] (Homo sapiens)
    - FCHo proteins bind nascent clathrin-coated pit (Homo sapiens)
      - PI(4,5)P2:AP-2:clathrin [plasma membrane] (Homo sapiens)
        
        clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTC [cytosol] (Homo sapiens)
      - PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:AP-2:clathrin [plasma membrane] (Homo sapiens)
        
        clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTC [cytosol] (Homo sapiens)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        Clathrin-coated vesicle [cytosol] (Homo sapiens)
        
        clathrin [cytosol] (Homo sapiens)
        
        CLTC [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        Clathrin-coated vesicle [cytosol] (Homo sapiens)
        
        clathrin [cytosol] (Homo sapiens)
        
        CLTC [cytosol] (Homo sapiens)
        
        clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTC [cytosol] (Homo sapiens)
      - clathrin:HSPA8:ADP [cytosol] (Homo sapiens)
        
        clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTC [cytosol] (Homo sapiens)
    - Initial binding of AP-2 and clathrin to PI(4,5)P2 (Homo sapiens)
      - PI(4,5)P2:AP-2:clathrin [plasma membrane] (Homo sapiens)
        
        clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTC [cytosol] (Homo sapiens)
      - clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTC [cytosol] (Homo sapiens)
    - RAB5 and GAPVD1 bind AP-2 (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        Clathrin-coated vesicle [cytosol] (Homo sapiens)
        
        clathrin [cytosol] (Homo sapiens)
        
        CLTC [cytosol] (Homo sapiens)
    - Recruitment of AP-2 complex and clathrin (Homo sapiens)
      - PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:AP-2:clathrin [plasma membrane] (Homo sapiens)
        
        clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTC [cytosol] (Homo sapiens)
      - PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:AP-2:clathrin [plasma membrane] (Homo sapiens)
        
        clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTC [cytosol] (Homo sapiens)
        
        clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTC [cytosol] (Homo sapiens)
      - clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTC [cytosol] (Homo sapiens)
    - SNX9 recruits components of the actin polymerizing machinery (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTC [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTC [cytosol] (Homo sapiens)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTC [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTC [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q00610 CLTC

Gene Names

CLTC, CLH17, CLTCL2, KIAA0034

Chain

initiator methionine:, chain:2-1675

Reference Genes

BioGPS Gene:1213 CLTC

COSMIC (genes):CLTC CLTC

CTD Gene:1213 CLTC

dbSNP Gene:1213 CLTC

ENSEMBL:ENSG00000141367 CLTC

ENSEMBL_homo_sapiens_GENE:ENSG00000141367.13 CLTC

HGNC:2092 CLTC

KEGG Gene (Homo sapiens):1213 CLTC

Monarch:1213 CLTC

NCBI Gene:1213 CLTC

OMIM:118955 CLTC

UCSC:Q00610 CLTC

Reference Transcript

RefSeq:NM_004859.3 CLTC

Other Identifiers

11739027_at

11739028_s_at

11739029_a_at

11739030_s_at

11746341_a_at

1213

16836564

200614_PM_at

200614_at

3728897

3728898

3729173

3729174

3729175

3729177

3729178

3729179

3729181

3729183

3729184

3729186

3729188

3729189

3729190

3729191

3729193

3729194

3729195

3729196

3729197

3729199

3729201

3729202

3729203

3729204

3729205

3729206

3729207

3729208

3729209

3729210

3729211

3729212

3729213

3729214

3729216

3729218

3729223

3729224

3729225

3729226

3729227

3729228

3729229

3729230

41159_at

8008834

84461_at

91168_at

A_14_P116029

A_14_P122089

A_23_P118544

A_33_P3274731

A_33_P3353170

D21260_at

GE57114

GO:0000278

GO:0001649

GO:0003723

GO:0003725

GO:0005198

GO:0005515

GO:0005576

GO:0005615

GO:0005737

GO:0005764

GO:0005768

GO:0005773

GO:0005794

GO:0005819

GO:0005829

GO:0005856

GO:0005886

GO:0005905

GO:0005925

GO:0005975

GO:0006886

GO:0006898

GO:0006914

GO:0007010

GO:0007049

GO:0012505

GO:0016020

GO:0016192

GO:0019901

GO:0030118

GO:0030130

GO:0030132

GO:0030136

GO:0030154

GO:0030659

GO:0030669

GO:0031410

GO:0031623

GO:0032051

GO:0032588

GO:0032991

GO:0033572

GO:0036020

GO:0042147

GO:0042470

GO:0043226

GO:0045334

GO:0046907

GO:0048268

GO:0050750

GO:0051301

GO:0060236

GO:0065003

GO:0070062

GO:0071439

GO:0072318

GO:0072583

GO:0072659

GO:0072686

GO:0097718

GO:0150093

GO:1900126

GO:1901135

GO:1903077

GO:1903561

GO:1990381

GO:1990498

HMNXSV003026476

HMNXSV003043633

ILMN_1756779

PH_hs_0022888

TC17000725.hg

g4758011_3p_at

Participates

as a component of

clathrin [cytosol] (Homo sapiens)

as a member of

Clathrin heavy chain [cytosol] (Homo sapiens)

as a candidate of

Other forms of this molecule

CLTC [trans-Golgi network membrane]

CLTC(2-1634)insDGVSSVTQAGVQWRDLGSLQPSRARLPGHVAADHPPA-ALK(1058-1620) fusion [cytosol]

CLTC(2-1634)insV-p-7Y-ALK(1059-1620) fusion [cytosol]

CLTC [plasma membrane]

CLTC [lysosomal membrane]

CLTC [clathrin-coated endocytic vesicle membrane]

CLTC [endolysosome membrane]

CLTC(2-1634)insV-ALK(1059-1620) fusion [cytosol]

CLTC(2-1634)insDGVSSVTQAGVQWRDLGSLQPSRARLPGHVAADHPPA-p-7Y-ALK(1058-1620) fusion [cytosol]

Inferred To

CLTC [cytosol] (Bos taurus)

CLTC [cytosol] (Canis familiaris)

CLTC [cytosol] (Sus scrofa)

Chc [cytosol] (Drosophila melanogaster)

chc-1 [cytosol] (Caenorhabditis elegans)

chc1 [cytosol] (Schizosaccharomyces pombe)

CHC1 [cytosol] (Saccharomyces cerevisiae)

CLTC-1 [cytosol] (Gallus gallus)

chcA [cytosol] (Dictyostelium discoideum)

Cltc [cytosol] (Mus musculus)

Cltc [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_004850.1

OpenTargets

ENSG00000141367

ZINC - Substances

CLH1_HUMAN

GeneCards

Q00610

HPA

ENSG00000141367-CLTC

Ensembl

ENSP00000269122, ENST00000700707, ENST00000269122, ENSG00000141367, ENSP00000376763, ENSP00000515147, ENST00000393043

ZINC target

Q00610

PRO

Q00610

Pharos - Targets

Q00610

Orphanet

21870

ZINC - Predictions - Purchasable

CLH1_HUMAN

PDB

6QNP, 6QNN, 2XZG, 4G55, 6E4L, 7ZX4, 7BN1, 7BN2

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P32121 ARRB2	3	ARRB2 [cytosol] (R-HSA-416464) PolyUb-ARRB2 [cytosol] (R-HSA-6783000) ARRB2 [endocytic vesicle membrane] (R-HSA-9910881)	0.676	6
UniProt:Q15398 DLGAP5	1	DLGAP5 [cytosol] (R-HSA-264452)	0.645	4
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	21
UniProt:P03372 ESR1	10	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) p-S167-ESR1 [cytosol] (R-HSA-9841254) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.597	3
UniProt:Q14164 IKBKE	5	monoSUMO1-K231-p-S172-IKBKE [nucleoplasm] (R-HSA-4755535) IKBKE [cytosol] (R-HSA-450225) p-S172-IKBKE [cytosol] (R-HSA-450278) K63polyUb-K30,K401-IKBKE [cytosol] (R-HSA-9730436) p-S172-IKBKE [nucleoplasm] (R-HSA-4755521)	0.589	2
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.569	11
UniProt:Q9NYZ3 GTSE1	4	GTSE1 [cytosol] (R-HSA-8852264) p-S435-GTSE1 [cytosol] (R-HSA-8852316) p-S435-GTSE1 [nucleoplasm] (R-HSA-8852332) p-T513,T526-GTSE1 [cytosol] (R-HSA-8852308)	0.564	3
UniProt:Q13627 DYRK1A	1	DYRK1A [nucleoplasm] (R-HSA-1362267)	0.547	2
UniProt:O14920 IKBKB	3	IKBKB Q432Pfs*62 [cytosol] (R-HSA-9628518) IKBKB [cytosol] (R-HSA-168114) p-S177,S181-IKBKB [cytosol] (R-HSA-202506)	0.536	2
UniProt:Q96FJ0 STAMBPL1	1	STAMBPL1 [cytosol] (R-HSA-6783264)	0.527	2
UniProt:P10242 MYB	1	MYB [nucleoplasm] (R-HSA-992697)	0.499	4
UniProt:P49407 ARRB1	6	ARRB1 [cytosol] (R-HSA-264470) PolyUb-ARRB1 [cytosol] (R-HSA-6783186) ARRB1 [endocytic vesicle membrane] (R-HSA-9910882) ARRB1 [lysosomal membrane] (R-HSA-432701) ARRB1 [Golgi membrane] (R-HSA-350831) ARRB1 [cytoplasmic vesicle membrane] (R-HSA-351187)	0.491	3

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