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PTK6 promotes HIF1A stabilization

Stable Identifier
R-HSA-8857538
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

HBEGF-stimulated formation of EGFR heterodimers with GPNMB triggers PTK6-mediated phosphorylation and stabilization of the hypoxia inducible factor 1 alpha (HIF1A) under normoxic conditions. This process depends on the presence of a long non-coding RNA LINC01139 (LINK-A) (Lin et al. 2016).

Literature References
PubMed ID Title Journal Year
26751287 The LINK-A lncRNA activates normoxic HIF1? signalling in triple-negative breast cancer Nat. Cell Biol. 2016
Participants
Participant Of
Orthologous Events
Cross References
BioModels Database