Reactome | LINC01139 promotes phosphorylation of HIF1A by PTK6

LINC01139 promotes phosphorylation of HIF1A by PTK6

Stable Identifier

R-HSA-8857583

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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LINC01139 promotes phosphorylation of HIF1A by PTK6

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PTK6 (BRK) tyrosine kinase, activated via long non-coding RNA LINC01139 (LINK-A) mediated recruitment to phosphorylated GPNMB (bound to HBEGF-activated EGFR), phosphorylates hypoxia inducible factor 1 alpha (HIF1A) at tyrosine residue Y565. Phosphorylation of HIF1A by PTK6 at Y565 inhibits HIF1A hydroxylation at proline P564, resulting in HIF1A stabilization under normoxic conditions (Lin et al. 2016).

Literature References

PubMed ID	Title	Journal	Year
26751287	The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer Marks, JR, Yang, L, Zhou, Y, Ma, G, Wang, S, Xing, Z, Liang, H, Lin, A, Hu, Z, Han, L, Hu, Q, Zhou, Y, Lin, C, Wang, C, Park, PK, Li, C, Zhou, J, Liang, K, Hung, MC, Zhang, Y, Wei, Y, Hawke, DH	Nat. Cell Biol.	2016