FITM1, FITM2 bind TAGs

Stable Identifier
R-HSA-8857686
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Lipid droplets (LDs) are cytosolic structures found in cells of all eukaryotes, comprising a monolayer of phospholipids surrounding a core of uncharged lipids such as triglyceride (TAG) and sterol esters. They play an important role in both cellular physiology and disease. LD formation involves the partitioning of neutral lipids from their site of synthesis at the endoplasmic reticulum (ER) to the cytosol. The fat storage-inducing transmembrane proteins 1 and 2 (FITM1 and FITM2) belong to an evolutionarily-conserved gene family which mediates LD formation (Kadereit et al. 2008, Gross et al. 2011). FITM1 and FITM2 are ER membrane associated proteins that mediate binding and partitioning of TAGs into LDs (Gross et al. 2011, Miranda et al. 2014). In mammals, FITM1 is expressed primarily in skeletal muscle whereas FITM2 is expressed primarily in adipose tissue, suggesting these proteins may have unique functions (Gross et al. 2011).

Literature References
PubMed ID Title Journal Year
24519944 Fat storage-inducing transmembrane protein 2 is required for normal fat storage in adipose tissue

Miranda, DA, Kim, JH, Nguyen, LN, Cheng, W, Tan, BC, Goh, VJ, Tan, JS, Yaligar, J, Kn, BP, Velan, SS, Wang, H, Silver, DL

J. Biol. Chem. 2014
22106267 Direct binding of triglyceride to fat storage-inducing transmembrane proteins 1 and 2 is important for lipid droplet formation

Gross, DA, Zhan, C, Silver, DL

Proc. Natl. Acad. Sci. U.S.A. 2011
18160536 Evolutionarily conserved gene family important for fat storage

Kadereit, B, Kumar, P, Wang, WJ, Miranda, D, Snapp, EL, Severina, N, Torregroza, I, Evans, T, Silver, DL

Proc. Natl. Acad. Sci. U.S.A. 2008
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