Reactome | p-Y307-PPP2CA [cytosol]

p-Y307-PPP2CA [cytosol]

Stable Identifier

R-HSA-8857939

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P67775 PPP2CA

Gene Names

PPP2CA

Chain

chain:1-309

Reference Genes

BioGPS Gene:5515 PPP2CA

COSMIC (genes):PPP2CA PPP2CA

CTD Gene:5515 PPP2CA

dbSNP Gene:5515 PPP2CA

ENSEMBL:ENSG00000113575 PPP2CA

HGNC:9299 PPP2CA

KEGG:hsa:5515 PPP2CA

Monarch:5515 PPP2CA

NCBI Gene:5515 PPP2CA

OMIM:176915 PPP2CA

UCSC:P67775 PPP2CA

Reference Transcript

RefSeq:NM_002715.4 PPP2CA

Participates

as a candidate of

p-Y307-PP2A-catalytic subunit C [cytosol] (Homo sapiens)

Other forms of this molecule

PPP2CA [cytosol]

PPP2CA [nucleoplasm]

MeL-PPP2CA [nucleoplasm]

Inferred To

phospho-mts [cytosol] (Drosophila melanogaster)

phospho-let-92 [cytosol] (Caenorhabditis elegans)

phospho-Ppp2ca [cytosol] (Mus musculus)

phospho-Ppp2ca [cytosol] (Rattus norvegicus)

phospho-pho2a [cytosol] (Dictyostelium discoideum)

phospho-PPP2CA [cytosol] (Bos taurus)

phospho-PPP2CA [cytosol] (Canis familiaris)

phospho-PPP2CA [cytosol] (Sus scrofa)

phospho-PPH21 [cytosol] (Saccharomyces cerevisiae)

phospho-ppa2 [cytosol] (Schizosaccharomyces pombe)

Modified Residues

Name

O4'-phospho-L-tyrosine at 307

Coordinate

307

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_002706.1

Guide to Pharmacology - Targets

3263

OpenTargets

ENSG00000113575

ENSEMBL

ENSG00000113575, ENSP00000418447, ENST00000481195

GeneCards

PPP2CA

HPA

ENSG00000113575-PPP2CA

ZINC target

P67775

PRO

P67775

Pharos - Targets

P67775

GlyGen

P67775

HMDB Protein

HMDBP02514

PDB

3K7W, 3K7V, 2IAE, 4IYP, 7CUN, 5W0W, 8TTB, 8UWB, 3P71, 2IE4, 2IE3, 7K36, 4I5N, 8SO0, 4LAC, 2NYL, 7SOY, 7PKS, 6NTS, 4I5L, 2NYM, 8RC4, 3FGA, 8TWI, 8TWE, 8RBZ, 3C5W, 4NY3, 8U89, 8RBX, 2NPP, 3DW8, 8U1X, 7YCX

Interactors (113)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P30153 PPP2R1A	2	PPP2R1A [cytosol] (R-HSA-165982) PPP2R1A [nucleoplasm] (R-HSA-165968)	0.984	50
UniProt:P78318 IGBP1			0.959	20
UniProt:Q13362 PPP2R5C	3	PPP2R5C [cytosol] (R-HSA-3008954) p-S337-PPP2R5C [cytosol] (R-HSA-6811447) PPP2R5C [nucleoplasm] (R-HSA-3008946)	0.934	11
UniProt:P30154 PPP2R1B	2	PPP2R1B [cytosol] (R-HSA-165980) PPP2R1B [nucleoplasm] (R-HSA-166000)	0.919	9
UniProt:P63151 PPP2R2A	2	PPP2R2A [nucleoplasm] (R-HSA-1564978) PPP2R2A [cytosol] (R-HSA-377253)	0.915	12
UniProt:Q15173 PPP2R5B	2	p-S368-PPP2R5B [cytosol] (R-HSA-6811453) PPP2R5B [cytosol] (R-HSA-535469)	0.908	8
UniProt:Q15172 PPP2R5A	2	p-S28-PPP2R5A [cytosol] (R-HSA-9836658) PPP2R5A [cytosol] (R-HSA-196235)	0.903	8
UniProt:Q5VSL9 STRP1			0.899	10
UniProt:Q9Y570 PPME1	1	PPME1 [nucleoplasm] (R-HSA-8857790)	0.877	9
UniProt:Q14738 PPP2R5D	2	PPP2R5D [nucleoplasm] (R-HSA-3008956) PPP2R5D [cytosol] (R-HSA-3008950)	0.864	8
UniProt:Q13136 PPFIA1	1	PPFIA1 [cytosol] (R-HSA-383377)	0.864	8
UniProt:Q16537 PPP2R5E	1	PPP2R5E [cytosol] (R-HSA-1638770)	0.855	7
UniProt:Q5FBB7 SGO1	3	SGOL1 [cytosol] (R-HSA-376227) SGO1 [nucleoplasm] (R-HSA-2468161) p-S-SGO1 [nucleoplasm] (R-HSA-9929718)	0.848	7
UniProt:Q66LE6 PPP2R2D	1	PPP2R2D [nucleoplasm] (R-HSA-2160962)	0.848	10
UniProt:O43815 STRN	5	STRN [cytosol] (R-HSA-9037081) STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673902) p-11Y-STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673908) STRN(1-137)-ALK(1058-1620) fusion [cytosol] (R-HSA-9700485) STRN(1-137)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9700467)	0.84	7
UniProt:Q13033 STRN3			0.831	9
UniProt:Q9Y3A3 PHOCN			0.823	9
UniProt:Q99832 CCT7	1	CCT7 [cytosol] (R-HSA-390451)	0.788	5
UniProt:Q15645 PCH2			0.764	6
UniProt:Q9NRL3 STRN4			0.758	5
UniProt:O75145 PPFIA3	1	PPFIA3 [cytosol] (R-HSA-383382)	0.758	5
UniProt:P78371 CCT2	3	CCT2 [cytosol] (R-HSA-390464) CCT2 [azurophil granule lumen] (R-HSA-6799356) CCT2 [extracellular region] (R-HSA-6806220)	0.758	5
UniProt:P17987 TCP1	1	TCP1 [cytosol] (R-HSA-390448)	0.758	5
UniProt:Q9P2B4 CT2NL			0.758	6
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-S473-AKT1 [plasma membrane] (R-HSA-377265) AKT1 [plasma membrane] (R-HSA-199416) AKT1 [cytosol] (R-HSA-58252) p-T308-AKT1 [cytosol] (R-HSA-198634) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-S473-AKT1 [cytosol] (R-HSA-9841264) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [cytosol] (R-HSA-2219526) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994)	0.756	4
UniProt:Q14BN4 SLMAP			0.745	5
UniProt:P22830 FECH	1	FECH [mitochondrial inner membrane] (R-HSA-189441)	0.745	5
UniProt:Q76MZ3 Ppp2r1a	2	Ppp2r1a [nucleoplasm] (R-MMU-165968) PP2A A subunit [cytosol] (R-MMU-206067)	0.743	4
UniProt:Q9BRV8 SIKE1	1	SIKE1 [cytosol] (R-HSA-916828)	0.725	5
UniProt:P48643 CCT5	1	CCT5 [cytosol] (R-HSA-390447)	0.725	4
UniProt:Q16204 CCDC6			0.725	4
UniProt:P50991 CCT4	1	CCT4 [cytosol] (R-HSA-390458)	0.725	4
UniProt:P50990 CCT8	5	CCT8 [cytosol] (R-HSA-390449) CCT8 [ficolin-1-rich granule lumen] (R-HSA-6800894) CCT8 [extracellular region] (R-HSA-6806238) CCT8 [secretory granule lumen] (R-HSA-6801035) CCT8 [azurophil granule lumen] (R-HSA-6799369)	0.725	4
UniProt:P49368 CCT3	1	CCT3 [cytosol] (R-HSA-390463)	0.725	4
UniProt:P40227 CCT6A	1	CCT6A [cytosol] (R-HSA-390454)	0.725	4
UniProt:Q9Y2T4 2ABG			0.708	6
UniProt:Q96CB8 INTS12	1	INTS12 [nucleoplasm] (R-HSA-6807456)	0.643	3
UniProt:Q9NVR7 TBCC1			0.643	3
UniProt:Q9Y5P8 PPP2R3B	1	PPP2R3B [nucleoplasm] (R-HSA-3008955)	0.643	3
UniProt:Q9UL03 INTS6	1	INTS6 [nucleoplasm] (R-HSA-6807440)	0.643	3
UniProt:Q8TF05 PP4R1			0.643	3
UniProt:Q5THK1 PR14L			0.643	3
UniProt:Q13033-2 STRN3			0.643	4
UniProt:Q9Y6E0 STK24	4	STK24 [cytosol] (R-HSA-351829) STK24(1-313) [cytosol] (R-HSA-351892) STK24(314-443) [cytosol] (R-HSA-351898) STK24(1-313) [nucleoplasm] (R-HSA-351944)	0.643	3
UniProt:Q9NVK5 FGFR1OP2	2	FGFR1OP(1-132)-FGFR1(429-822) fusion [cytosol] (R-HSA-1606443) FGFR1OP(1-132)-p-FGFR1(429-822) fusion [cytosol] (R-HSA-1838998)	0.643	4
UniProt:Q96HW7 INTS4	1	INTS4 [nucleoplasm] (R-HSA-6807462)	0.643	3
UniProt:Q06190 P2R3A			0.643	4
UniProt:Q86XL3 ANKLE2	2	ANKLE2 [endoplasmic reticulum membrane] (R-HSA-2529000) Ac-K302-ANKLE2 [endoplasmic reticulum membrane] (R-HSA-9667946)	0.643	3
UniProt:O00506 STK25			0.643	3
UniProt:Q9P289 STK26	3	MST4 [cytosol] (R-HSA-351918) MST4(1-305) [cytosol] (R-HSA-351855) MST4(306-416) [cytosol] (R-HSA-351903)	0.643	4
UniProt:O15169 AXIN1	11	AXIN1 [cytosol] (R-HSA-195249) p-T481,S486,S493-AXIN1 [cytosol] (R-HSA-206040) ub-AXIN1 [cytosol] (R-HSA-4641133) RibC-AXIN1 [cytosol] (R-HSA-3640841) Ub-RibC-AXIN1 [cytosol] (R-HSA-3640864) AXIN1 P255S [cytosol] (R-HSA-5251505) AXIN1 P354L [cytosol] (R-HSA-5251511) AXIN1 W247* [cytosol] (R-HSA-5251512) AXIN1 E406* [cytosol] (R-HSA-5251500) AXIN1 Y346* [cytosol] (R-HSA-4839753) AXIN1 L396M [cytosol] (R-HSA-5251503)	0.643	4
UniProt:Q9Y6K9 IKBKG	12	IKBKG [cytosol] (R-HSA-168108) Ub-285-IKBKG [cytosol] (R-HSA-741397) K63polyUb-IKBKG [cytosol] (R-HSA-202530) IKBKG [nucleoplasm] (R-HSA-4755413) monoSUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG 420Wext447 [cytosol] (R-HSA-5262978) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG D406V [cytosol] (R-HSA-5262943)	0.641	4
UniProt:O14920 IKBKB	3	IKBKB [cytosol] (R-HSA-168114) p-S177,S181-IKBKB [cytosol] (R-HSA-202506) IKBKB Q432Pfs*62 [cytosol] (R-HSA-9628518)	0.641	3
UniProt:Q61249 IGBP1			0.602	3
UniProt:P03129 VE7			0.602	3
UniProt:Q14674 ESPL1	4	ESPL1(1-1506) [cytosol] (R-HSA-2467768) ESPL1(1507-1535) [cytosol] (R-HSA-2500272) ESPL1(1536-2120) [cytosol] (R-HSA-2467767) ESPL1 [cytosol] (R-HSA-1638167)	0.597	3
UniProt:Q00005 2ABB			0.597	5
UniProt:Q969F8 KISS1R	1	KISS1R [plasma membrane] (R-HSA-388974)	0.593	3
UniProt:Q04206 RELA	7	RELA [nucleoplasm] (R-HSA-177676) RELA [cytosol] (R-HSA-168172) p-S276-RELA [nucleoplasm] (R-HSA-5624468) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) polySUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) p-S536-RELA [nucleoplasm] (R-HSA-9861499) MeK310-RELA [nucleoplasm] (R-HSA-8865233)	0.591	6
UniProt:O75663 TIPRL			0.589	3
UniProt:Q562F6 SGO2	1	SGOL2 [cytosol] (R-HSA-376242)	0.564	2
UniProt:Q9UPQ4-2 Q9UPQ42			0.556	3
UniProt:Q5T6F2 UBAP2			0.556	3
IntAct:EBI-22384931 CCSB ORF ID			0.556	3
UniProt:Q16740 CLPP	1	CLPP [mitochondrial matrix] (R-HSA-9838002)	0.556	3
UniProt:Q08AM6 VAC14	3	VAC14 [Golgi membrane] (R-HSA-1806235) VAC14 [early endosome membrane] (R-HSA-1806207) VAC14 [late endosome membrane] (R-HSA-1806219)	0.556	3
UniProt:Q96JM7-2 L3MBTL3			0.556	3
UniProt:Q3SXR2 CC036			0.556	3
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	3
UniProt:P28749 RBL1	2	RBL1 [nucleoplasm] (R-HSA-389104) p-T369,S640,S964,S975-RBL1 [nucleoplasm] (R-HSA-1226085)	0.544	2
UniProt:P04049 RAF1	20	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098)	0.544	2
UniProt:Q08999 RBL2	2	RBL2 [nucleoplasm] (R-HSA-389102) p-T401,S672,S1035-RBL2 [nucleoplasm] (R-HSA-1226084)	0.544	2
UniProt:Q9NV88 INTS9	1	INTS9 [nucleoplasm] (R-HSA-6807424)	0.527	2
UniProt:Q9H0H0 INTS2	1	INTS2 [nucleoplasm] (R-HSA-6807448)	0.527	2
UniProt:Q9BWN1 PRR14			0.527	2
UniProt:Q77M19 V			0.527	2
UniProt:Q5TA45 CPSF3L	1	CPSF3L [nucleoplasm] (R-HSA-6807411)	0.527	2
UniProt:Q9NVR2 INTS10	1	INTS10 [nucleoplasm] (R-HSA-6807420)	0.527	2
UniProt:Q969G9 NKD1			0.527	2
UniProt:Q9NQX6 ZNF331	1	ZNF331 [nucleoplasm] (R-HSA-1247549)	0.527	3
UniProt:O95684 CEP43	3	FGFR1OP(2-163)-FGFR1(429-822) fusion [cytosol] (R-HSA-1604533) FGFR1OP(2-163)-p-FGFR1(429-822) fusion [cytosol] (R-HSA-1838994) FGFR1OP [cytosol] (R-HSA-380309)	0.527	2
UniProt:P68104 EEF1A1	7	EEF1A1 [lysosomal membrane] (R-HSA-9626022) EEF1A1 [cytosol] (R-HSA-156905) EEF1A1 [ficolin-1-rich granule lumen] (R-HSA-6801528) EEF1A1 [extracellular region] (R-HSA-6806456) EEF1A1 [secretory granule lumen] (R-HSA-6801479) Me3K318-EEF1A1 [cytosol] (R-HSA-8932419) Me3K79-EEF1A1 [cytosol] (R-HSA-8932212)	0.527	3
UniProt:Q6ZMY9 ZNF517	1	ZNF517 [nucleoplasm] (R-HSA-1973869)	0.527	2
UniProt:O43638 FOXS1			0.527	2
UniProt:Q8IYG6 LRC56			0.527	2
UniProt:Q96SY0 VWA9	1	VWA9 [nucleoplasm] (R-HSA-6807412)	0.527	2
UniProt:Q9NVH2 INTS7	1	INTS7 [nucleoplasm] (R-HSA-6807401)	0.527	2
UniProt:Q12950 FOXD4			0.527	3
UniProt:Q9NUC0 SRTD4			0.527	3
UniProt:P42695 NCAPD3	3	p-T1415,S1419-NCAPD3 [nucleoplasm] (R-HSA-2294594) p-T1415-NCAPD3 [nucleoplasm] (R-HSA-2294587) NCAPD3 [nucleoplasm] (R-HSA-1629790)	0.527	2
UniProt:Q8NC26 ZNF114	1	ZNF114 [nucleoplasm] (R-HSA-975026)	0.527	2
UniProt:Q96H86 ZNF764	1	ZNF764 [nucleoplasm] (R-HSA-3343766)	0.527	2
UniProt:Q9BXL8 CDCA4			0.527	4
UniProt:Q92974 ARHGEF2	1	ARHGEF2 [cytosol] (R-HSA-195101)	0.527	2
UniProt:Q7Z398 ZNF550	1	ZNF550 [nucleoplasm] (R-HSA-1973896)	0.527	2
UniProt:Q6P9B9 INTS5	1	INTS5 [nucleoplasm] (R-HSA-6807418)	0.527	2
UniProt:O00755 WNT7A	9	WNT7A [extracellular region] (R-HSA-517404) N4GlycoAsn-PalmS WNT7A [extracellular exosome] (R-HSA-3781951) N4GlycoAsn-PalmS WNT7A [endocytic vesicle membrane] (R-HSA-3781961) WNT7A [endoplasmic reticulum lumen] (R-HSA-3238312) N4GlycoAsn-WNT7A [endoplasmic reticulum lumen] (R-HSA-3238249) N4GlycoAsn-PalmS WNT7A [endoplasmic reticulum lumen] (R-HSA-3238354) N4GlycoAsn-PalmS WNT7A [Golgi lumen] (R-HSA-3247778) N4GlycoAsn-PalmS WNT7A [extracellular region] (R-HSA-3247774) N4GlycoAsn-PalmS WNT7A [plasma membrane] (R-HSA-3247833)	0.527	2
UniProt:O60293 ZFC3H1	1	ZFC3H1 [nucleoplasm] (R-HSA-9930046)	0.527	2
UniProt:Q9Y228 T3JAM			0.527	3
UniProt:Q9BUL8 PDC10			0.527	2
UniProt:Q75QN2 INTS8	1	INTS8 [nucleoplasm] (R-HSA-6807409)	0.527	2
UniProt:Q8N201 INTS1	1	INTS1 [nucleoplasm] (R-HSA-6807446)	0.527	2
UniProt:Q96E09 PBIR1			0.527	2
UniProt:Q8IYD2 KLD8A			0.527	2
UniProt:Q68E01 INTS3	1	INTS3 [nucleoplasm] (R-HSA-6807435)	0.527	2
UniProt:P62714 PPP2CB	4	MeL-PPP2CB [nucleoplasm] (R-HSA-8857799) p-Y307-PPP2CB [cytosol] (R-HSA-8857935) PPP2CB [nucleoplasm] (R-HSA-165991) PPP2CB [cytosol] (R-HSA-165987)	0.527	2
UniProt:P04020 VE7			0.524	2
UniProt:P46695 IER3	1	IER3 [cytosol] (R-HSA-6811515)	0.524	2
UniProt:P06730 EIF4E	1	EIF4E [cytosol] (R-HSA-72578)	0.524	2
UniProt:P97346 NXN			0.524	2
UniProt:Q14653 IRF3	6	IRF3 [cytosol] (R-HSA-166251) IRF3(2-271) [cytosol] (R-HSA-9729696) IRF3(272-427) [cytosol] (R-HSA-9729737) p-4S,T404-IRF3 [cytosol] (R-HSA-166258) p-4S,T404-IRF3 [nucleoplasm] (R-HSA-177654) p-5S,T404-IRF3 [nucleoplasm] (R-HSA-936418)	0.499	4
UniProt:P10415 BCL2	1	BCL2 [mitochondrial outer membrane] (R-HSA-50757)	0.488	2
UniProt:P01106 MYC	2	MYC [nucleoplasm] (R-HSA-188379) PolyUb-MYC [nucleoplasm] (R-HSA-6783169)	0.462	2

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