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p-Y307-PPP2CA [cytosol]
Stable Identifier
R-HSA-8857939
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Homo sapiens)
p-Y307-PP2A [cytosol] (Homo sapiens)
p-Y307-PP2A-catalytic subunit C [cytosol] (Homo sapiens)
p-Y307-PPP2CA [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P67775 PPP2CA
Gene Names
PPP2CA
Chain
chain:1-309
Reference Genes
BioGPS Gene:5515 PPP2CA
COSMIC (genes):PPP2CA PPP2CA
CTD Gene:5515 PPP2CA
dbSNP Gene:5515 PPP2CA
ENSEMBL:ENSG00000113575 PPP2CA
HGNC:9299 PPP2CA
KEGG Gene (Homo sapiens):5515 PPP2CA
Monarch:5515 PPP2CA
NCBI Gene:5515 PPP2CA
OMIM:176915 PPP2CA
UCSC:P67775 PPP2CA
Reference Transcript
RefSeq:NM_002715.2 PPP2CA
Other Identifiers
0000360079
11715804_s_at
11715805_a_at
11758731_at
17000022
208652_at
235502_at
237_s_at
238719_at
2876044
2876045
2876047
2876048
2876049
2876050
2876051
2876052
2876053
2876054
2876055
2876056
2876058
2876060
2876061
2876062
2876066
2876067
2876075
2876076
2876077
2876078
33181_at
48243_at
54851_at
5515
8114158
A_23_P122041
A_24_P183375
GE57999
GO:0000003
GO:0000159
GO:0000184
GO:0000188
GO:0000278
GO:0000775
GO:0000922
GO:0001932
GO:0003674
GO:0004721
GO:0004722
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005694
GO:0005737
GO:0005739
GO:0005829
GO:0005856
GO:0005886
GO:0006275
GO:0006355
GO:0006464
GO:0006470
GO:0006629
GO:0006672
GO:0006915
GO:0007049
GO:0007084
GO:0007155
GO:0007165
GO:0007267
GO:0007498
GO:0008022
GO:0008092
GO:0008150
GO:0008219
GO:0008380
GO:0009056
GO:0009058
GO:0010033
GO:0010288
GO:0010719
GO:0015630
GO:0016020
GO:0016787
GO:0016791
GO:0019932
GO:0030111
GO:0030154
GO:0030155
GO:0030308
GO:0032991
GO:0034641
GO:0034655
GO:0035970
GO:0040007
GO:0040008
GO:0042532
GO:0043167
GO:0043226
GO:0045121
GO:0045595
GO:0046872
GO:0046982
GO:0048156
GO:0048856
GO:0050811
GO:0051321
GO:0061024
GO:0070062
GO:0070262
GO:0071902
GO:1904526
GO:1904528
Hs.102243.0.A1_3p_at
Hs.102243.0.A1_3p_x_at
Hs.79204.0.S1_3p_at
ILMN_1722858
ILMN_2196097
M60483_rna1_s_at
PH_hs_0005098
TC05003406.hg
g12653262_3p_at
Participant Of
hasCandidate
p-Y307-PP2A-catalytic subunit C [cytosol]
Other forms of this molecule
PPP2CA [cytosol]
PPP2CA [nucleoplasm]
MeL-PPP2CA [nucleoplasm]
Inferred To
phospho-ppp2caa [cytosol] (Danio rerio)
phospho-mts [cytosol] (Drosophila melanogaster)
phospho-ppp2ca [cytosol] (Xenopus tropicalis)
phospho-let-92 [cytosol] (Caenorhabditis elegans)
phospho-Ppp2ca [cytosol] (Mus musculus)
phospho-Ppp2ca [cytosol] (Rattus norvegicus)
phospho-pho2a [cytosol] (Dictyostelium discoideum)
phospho-PPP2CA [cytosol] (Bos taurus)
phospho-ppa2 [cytosol] (Schizosaccharomyces pombe)
Modified Residues
Name
O4'-phospho-L-tyrosine at 307
Coordinate
307
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_002706.1
Target Pathogen
5b2801b2be737e35a6de7df9
,
57c0ab57be737e1cc0a9d407
,
5b2801b2be737e35a6dea775
OpenTargets
ENSG00000113575
HPA
ENSG00000113575-PPP2CA
GeneCards
P67775
ZINC target
P67775
Ensembl
ENSP00000418447
,
ENSG00000113575
,
ENST00000481195
PRO
P67775
HMDB Protein
HMDBP02514
PDB
2NYM
,
4I5L
,
3FGA
,
5W0W
,
2NYL
,
4IYP
,
3DW8
,
3C5W
,
2IAE
,
4I5N
,
3P71
,
3K7W
,
3K7V
,
2NPP
,
6NTS
,
2IE3
,
4LAC
,
2IE4
Interactors (23)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q15173 PPP2R5B
2
PPP2R5B [cytosol]
(R-HSA-535469)
p-S368-PPP2R5B [cytosol]
(R-HSA-6811453)
0.788
5
UniProt:P31749 AKT1
13
p-T308,S473-AKT1 E17K [cytosol]
(R-HSA-2243935)
p-T308,S473-AKT1 E17K [nucleoplasm]
(R-HSA-2399994)
AKT1 E17K [cytosol]
(R-HSA-2219526)
p-S473-AKT1 E17K [plasma membrane]
(R-HSA-2243944)
AKT1 E17K [plasma membrane]
(R-HSA-1500573)
p-T308,S473-AKT1 [plasma membrane]
(R-HSA-199430)
p-Y315,Y326-AKT1 [cytosol]
(R-HSA-8848757)
p-T308-AKT1 [cytosol]
(R-HSA-198634)
p-T308,S473-AKT1 [nucleoplasm]
(R-HSA-198357)
AKT1 [cytosol]
(R-HSA-58252)
AKT1 [plasma membrane]
(R-HSA-199416)
p-S473-AKT1 [plasma membrane]
(R-HSA-377265)
p-T308,S473-AKT1 [cytosol]
(R-HSA-198356)
0.756
4
UniProt:O43815 STRN
3
STRN(1-265)-PDGFRA(580-1089) fusion [cytosol]
(R-HSA-9673902)
STRN [cytosol]
(R-HSA-9037081)
p-11Y STRN(1-265)-PDGFRA(580-1089) fusion [cytosol]
(R-HSA-9673908)
0.737
5
UniProt:Q9Y570 PPME1
1
PPME1 [nucleoplasm]
(R-HSA-8857790)
0.725
5
UniProt:Q9BRV8 SIKE1
1
SIKE1 [cytosol]
(R-HSA-916828)
0.725
5
UniProt:P17987 TCP1
1
TCP1 [cytosol]
(R-HSA-390448)
0.69
4
UniProt:O15169 AXIN1
11
AXIN1 Y346* [cytosol]
(R-HSA-4839753)
AXIN1 L396M [cytosol]
(R-HSA-5251503)
AXIN1 E406* [cytosol]
(R-HSA-5251500)
AXIN1 W247* [cytosol]
(R-HSA-5251512)
AXIN1 P354L [cytosol]
(R-HSA-5251511)
AXIN1 P255S [cytosol]
(R-HSA-5251505)
ub-AXIN1 [cytosol]
(R-HSA-4641133)
AXIN1 [cytosol]
(R-HSA-195249)
p-T519,S524,S531-AXIN1 [cytosol]
(R-HSA-206040)
RibC-AXIN1 [cytosol]
(R-HSA-3640841)
Ub-RibC-AXIN1 [cytosol]
(R-HSA-3640864)
0.643
4
UniProt:O14920 IKBKB
3
p-S177,S181-IKBKB [cytosol]
(R-HSA-202506)
IKBKB Q432Pfs*62 [cytosol]
(R-HSA-9628518)
IKBKB [cytosol]
(R-HSA-168114)
0.641
3
UniProt:Q9Y6K9 IKBKG
12
IKBKG [nucleoplasm]
(R-HSA-4755413)
SUMO1-K277,K309-IKBKG [nucleoplasm]
(R-HSA-4755449)
IKBKG D406V [cytosol]
(R-HSA-5262943)
IKBKG L153R [cytosol]
(R-HSA-5262879)
IKBKG E391* [cytosol]
(R-HSA-5262924)
IKBKG C417R [cytosol]
(R-HSA-5262858)
IKBKG R173G [cytosol]
(R-HSA-5262966)
IKBKG R175P [cytosol]
(R-HSA-5262916)
IKBKG *420Wro*447 [cytosol]
(R-HSA-5262978)
Ub-285-IKBKG [cytosol]
(R-HSA-741397)
K63polyUb-NEMO [cytosol]
(R-HSA-202530)
IKBKG [cytosol]
(R-HSA-168108)
0.641
4
UniProt:Q969F8 KISS1R
1
KISS1R [plasma membrane]
(R-HSA-388974)
0.593
3
UniProt:Q04206 RELA
6
MeK310-RELA [nucleoplasm]
(R-HSA-8865233)
SUMO3-K37,K122,K123-RELA [nucleoplasm]
(R-HSA-4755466)
p-S276,5xAcK-RELA [nucleoplasm]
(R-HSA-5660642)
p-S276-RELA [nucleoplasm]
(R-HSA-5624468)
RELA [nucleoplasm]
(R-HSA-177676)
RELA [cytosol]
(R-HSA-168172)
0.591
6
UniProt:P05067 APP
20
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
UniProt:P28749 RBL1
2
p-T369,S640,S964,S975-RBL1 [nucleoplasm]
(R-HSA-1226085)
RBL1 [nucleoplasm]
(R-HSA-389104)
0.544
2
UniProt:P04049 RAF1
54
p-S338,Y340,Y341-RAF1 [cytosol]
(R-HSA-5624465)
RAF1 [cytosol]
(R-HSA-167205)
p-S338-RAF1 [cytosol]
(R-HSA-5624469)
p-S621-RAF1 S259F [cytosol]
(R-HSA-9656124)
p-S621-RAF1 S257L [cytosol]
(R-HSA-9656121)
p-S621-RAF1 P261L [cytosol]
(R-HSA-9656106)
p-S621-RAF1 N262K [cytosol]
(R-HSA-9656101)
p-S621-RAF1 P261A [cytosol]
(R-HSA-9656103)
p-S621-RAF1 P261S [cytosol]
(R-HSA-9656113)
p-S621-RAF1 S259T [cytosol]
(R-HSA-9656130)
p-S621-RAF1 P261T [cytosol]
(R-HSA-9656115)
p-S621-RAF1 P261R [cytosol]
(R-HSA-9656110)
p-S621-RAF1 S259P [cytosol]
(R-HSA-9656127)
p-S621-RAF1 T260I [cytosol]
(R-HSA-9656136)
p-S621-RAF1 T260R [cytosol]
(R-HSA-9656139)
p-S621-RAF1 V263A [cytosol]
(R-HSA-9656148)
p-S621-RAF1 R256S [cytosol]
(R-HSA-9656119)
p-S621-RAF1 T491I [cytosol]
(R-HSA-9656143)
p-S621-RAF1 D486N [cytosol]
(R-HSA-9656088)
p-S621-RAF1 S427G [cytosol]
(R-HSA-9656134)
p-S621-RAF1 L613V [cytosol]
(R-HSA-9656098)
p-S621-RAF1 G361A [cytosol]
(R-HSA-9656092)
p-S621-RAF1 G370R [cytosol]
(R-HSA-9656094)
p-S621-RAF1 D486G [cytosol]
(R-HSA-9656085)
p-S621-RAF1 T491R [cytosol]
(R-HSA-9656145)
p-S338,Y341,T492,S494,S621 RAF1 D486N [cytosol]
(R-HSA-9656026)
p-S338,Y341,T492,S494,S621 RAF1 S427G [cytosol]
(R-HSA-9656070)
p-S338,Y341,T492,S494,S621 RAF1 L613V [cytosol]
(R-HSA-9656035)
p-S338,Y341,S494,S621-RAF1 T491I [cytosol]
(R-HSA-9656019)
p-S338,Y341,T492,S494,S621 RAF1 G361A [cytosol]
(R-HSA-9656029)
p-S338,Y341,T492,S494,S621 RAF1 G370R [cytosol]
(R-HSA-9656031)
p-S338,Y341,T492,S494,S621 RAF1 D486G [cytosol]
(R-HSA-9656023)
p-S338,Y341,S494,S621 RAF1 T491R [cytosol]
(R-HSA-9656017)
p-S338,Y341,T492,S494,S621 RAF1 S259F [cytosol]
(R-HSA-9656062)
p-S338,Y341,T492,S494,S621 RAF1 P261A [cytosol]
(R-HSA-9656041)
p-S338,Y341,T492,S494,S621 RAF1 S257L [cytosol]
(R-HSA-9656058)
p-S338,Y341,T492,S494,S621 RAF1 P261L [cytosol]
(R-HSA-9656043)
p-S338,Y341,T492,S494,S621 RAF1 P261T [cytosol]
(R-HSA-9656053)
p-S338,Y341,T492,S494,S621 RAF1 N262K [cytosol]
(R-HSA-9656037)
p-S338,Y341,T492,S494,S621 RAF1 P261S [cytosol]
(R-HSA-9656050)
p-S338,Y341,T492,S494,S621 RAF1 S259T [cytosol]
(R-HSA-9656067)
p-S338,Y341,T492,S494,S621 RAF1 T260R [cytosol]
(R-HSA-9656077)
p-S338,Y341,T492,S494,S621 RAF1 P261R [cytosol]
(R-HSA-9656047)
p-S338,Y341,T492,S494,S621 RAF1 R256S [cytosol]
(R-HSA-9656056)
p-S338,Y341,T492,S494,S621 RAF1 T260I [cytosol]
(R-HSA-9656074)
p-S338,Y341,T492,S494,S621 RAF1 V263A [cytosol]
(R-HSA-9656080)
p-S338,Y341,T492,S494,S621 RAF1 S259P [cytosol]
(R-HSA-9656065)
hyperphosphorylated RAF1 [plasma membrane]
(R-HSA-5675193)
p-S621-RAF1 [plasma membrane]
(R-HSA-206222)
p-Y341,T491,S494,S621 RAF1 [plasma membrane]
(R-HSA-5675420)
p-S259,S621-RAF1 [cytosol]
(R-HSA-109786)
p-S621-RAF1 [cytosol]
(R-HSA-206028)
p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane]
(R-HSA-5672665)
p-S338,Y341,T491,S494,S621 RAF1 [cytosol]
(R-HSA-5672664)
0.544
2
UniProt:Q08999 RBL2
2
p-T401,S672,S1035-RBL2 [nucleoplasm]
(R-HSA-1226084)
RBL2 [nucleoplasm]
(R-HSA-389102)
0.544
2
UniProt:Q9P289 STK26
3
MST4 [cytosol]
(R-HSA-351918)
MST4(306-416) [cytosol]
(R-HSA-351903)
MST4(1-305) [cytosol]
(R-HSA-351855)
0.527
2
UniProt:Q9Y6E0 STK24
4
STK24(314-443) [cytosol]
(R-HSA-351898)
STK24(1-313) [nucleoplasm]
(R-HSA-351944)
STK24(1-313) [cytosol]
(R-HSA-351892)
STK24 [cytosol]
(R-HSA-351829)
0.527
2
UniProt:P46695 IER3
1
IER3 [cytosol]
(R-HSA-6811515)
0.524
2
UniProt:P06730 EIF4E
1
EIF4E [cytosol]
(R-HSA-72578)
0.524
2
UniProt:Q14653 IRF3
4
p-4S,T404-IRF3 [nucleoplasm]
(R-HSA-177654)
p-5S,T404-IRF3 [nucleoplasm]
(R-HSA-936418)
p-4S,T404-IRF3 [cytosol]
(R-HSA-166258)
IRF3 [cytosol]
(R-HSA-166251)
0.499
4
UniProt:P10415 BCL2
1
BCL2 [mitochondrial outer membrane]
(R-HSA-50757)
0.488
2
UniProt:Q14674 ESPL1
4
ESPL1(1507-1535) [cytosol]
(R-HSA-2500272)
ESPL1(1-1506) [cytosol]
(R-HSA-2467768)
ESPL1(1536-2120) [cytosol]
(R-HSA-2467767)
ESPL1 [cytosol]
(R-HSA-1638167)
0.462
2
UniProt:P01106 MYC
2
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
MYC [nucleoplasm]
(R-HSA-188379)
0.462
2
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