The H-RAS-like suppressor (HRASLS) subfamily consists of five enzymes (1–5) in humans that share sequence homology with lecithin:retinol acyltransferase (LRAT). All HRASLS members possess in vitro phospholipid metabolizing abilities including phospholipase A1/2 (PLA1/2) activities and O-acyltransferase activities for the remodeling of glycerophospholipid acyl chains (Golczak et al. 2012), as well as N-acyltransferase activities for the production of N-acylphosphatidylethanolamines (Mardian et al. 2015). Acyl chain remodelling can play a key role in regulating triglyceride accumulation and energy expenditure in adipocytes, making this process a potential target for treatment of metabolic disorders causing obesity. The example here describes the N-acyltransferase activity of HRASLSs for the production of N-acylphosphatidylethanolamines (NAPEs) (Uyama et al. 2012).
Mardian, EB, Duncan, RE, Bradley, RM
Shinohara, N, Uyama, T, Jin, XH, Tonai, T, Ueda, N, Tsuboi, K, Tokumura, A, Inoue, M, Ikematsu, N
Sears, AE, Kiser, PD, Blaner, WS, Golczak, M, Palczewski, K, Lodowski, DT
acyltransferase activity of HRASLS [cytosol]
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