PILRA,PILRB bind CD99

Stable Identifier
R-HSA-8862084
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The paired immunoglobulin-like type 2 receptors (PILR) comprise the inhibitory receptor PILRA and the activating receptor PILRB (Shiratori et al. 2004). The inhibitory PILRA is mainly expressed on macrophages, dendritic cells and granulocytes, whereas the activating PILRB is mainly on activated NK cells. Both recognize mouse CD99 as a ligand, but the binding affinity of PILRB is much lower (Tabata et al. 2008). Mouse NK cells expressing PILRB mediate cytotoxicity against CD99-positive target cells, suggesting that this receptor may be involved in NK cell recognition (Shiratori et al. 2004).

Literature References
PubMed ID Title Journal Year
18234675 Biophysical characterization of O-glycosylated CD99 recognition by paired Ig-like type 2 receptors

Tabata, S, Kuroki, K, Wang, J, Kajikawa, M, Shiratori, I, Kohda, D, Arase, H, Maenaka, K

J. Biol. Chem. 2008
Participants
Participant Of
Orthologous Events
Authored
Reviewed