PILRA binds PIANP, COLLEC12 trimer, NPDC1, CLEC4G

Stable Identifier
R-HSA-8862090
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
PILRA binds PIANP
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Paired immunoglobulin-like type 2 receptor alpha (PILRA) binds to multiple ligands including CD99 (Shiratori et al. 2004), PILR-associating neural protein (PIANP, PANP) (Kogure et al. 2011), Herpes simplex virus-1 glycoprotein B (Satoh et al. 2008), Collectin-12 (COLEC12), Neural proliferation differentiation and control protein 1 (NPDC1) and C-type lectin domain family 4 member G (CLEC4G) (Sun et al. 2012). Binding studies suggest that PILR recognizes a complex ligand domain involving both silica acid and protein motif(s). Thus, PILR is evolved to engage multiple ligands with common molecular determinants to modulate myeloid cell functions in anatomical settings where PILR ligands are expressed. The precise function of PILRa-Ligand interaction is not well understood (Sun et al. 2012). PILRa negatively regulates inflammation and keeps myeloid system in check. Pilra KO mice produce more pathogenic cytokines during inflammation and are prone to enhanced autoimmune arthritis. Correspondingly, anti-PILRa mAb ameliorated inflammation in mouse arthritis models and suppressed the production of proinflammatory cytokines (Sun et al. 2014).

Literature References
PubMed ID Title Journal Year
22396535 Evolutionarily conserved paired immunoglobulin-like receptor α (PILRα) domain mediates its interaction with diverse sialylated ligands

Sun, Y, Senger, K, Baginski, TK, Mazloom, A, Chinn, Y, Pantua, H, Hamidzadeh, K, Ramani, SR, Luis, E, Tom, I, Sebrell, A, Quinones, G, Ma, Y, Mukhyala, K, Sai, T, Ding, J, Haley, B, Shadnia, H, Kapadia, SB, Gonzalez, LC, Hass, PE, Zarrin, AA

J. Biol. Chem. 2012
21241660 PANP is a novel O-glycosylated PILRα ligand expressed in neural tissues

Kogure, A, Shiratori, I, Wang, J, Lanier, LL, Arase, H

Biochem. Biophys. Res. Commun. 2011
14970179 Activation of natural killer cells and dendritic cells upon recognition of a novel CD99-like ligand by paired immunoglobulin-like type 2 receptor

Shiratori, I, Ogasawara, K, Saito, T, Lanier, LL, Arase, H

J. Exp. Med. 2004
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