Reactome | PILRA binds PIANP, COLLEC12 trimer, NPDC1, CLEC4G

PILRA binds PIANP, COLLEC12 trimer, NPDC1, CLEC4G

Stable Identifier

R-HSA-8862090

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

PILRA binds PIANP

ReviewStatus

5/5

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PILRA binds PIANP, COLLEC12 trimer, NPDC1, CLEC4G

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Paired immunoglobulin-like type 2 receptor alpha (PILRA) binds to multiple ligands including CD99 (Shiratori et al. 2004), PILR-associating neural protein (PIANP, PANP) (Kogure et al. 2011), Herpes simplex virus-1 glycoprotein B (Satoh et al. 2008), Collectin-12 (COLEC12), Neural proliferation differentiation and control protein 1 (NPDC1) and C-type lectin domain family 4 member G (CLEC4G) (Sun et al. 2012). Binding studies suggest that PILR recognizes a complex ligand domain involving both silica acid and protein motif(s). Thus, PILR is evolved to engage multiple ligands with common molecular determinants to modulate myeloid cell functions in anatomical settings where PILR ligands are expressed. The precise function of PILRa-Ligand interaction is not well understood (Sun et al. 2012). PILRa negatively regulates inflammation and keeps myeloid system in check. Pilra KO mice produce more pathogenic cytokines during inflammation and are prone to enhanced autoimmune arthritis. Correspondingly, anti-PILRa mAb ameliorated inflammation in mouse arthritis models and suppressed the production of proinflammatory cytokines (Sun et al. 2014).

Literature References

PubMed ID	Title	Journal	Year
21241660	PANP is a novel O-glycosylated PILRα ligand expressed in neural tissues Kogure, A, Shiratori, I, Wang, J, Lanier, LL, Arase, H	Biochem. Biophys. Res. Commun.	2011
22396535	Evolutionarily conserved paired immunoglobulin-like receptor α (PILRα) domain mediates its interaction with diverse sialylated ligands Sun, Y, Senger, K, Baginski, TK, Mazloom, A, Chinn, Y, Pantua, H, Hamidzadeh, K, Ramani, SR, Luis, E, Tom, I, Sebrell, A, Quinones, G, Ma, Y, Mukhyala, K, Sai, T, Ding, J, Haley, B, Shadnia, H, Kapadia, SB, Gonzalez, LC, Hass, PE, Zarrin, AA	J. Biol. Chem.	2012
14970179	Activation of natural killer cells and dendritic cells upon recognition of a novel CD99-like ligand by paired immunoglobulin-like type 2 receptor Shiratori, I, Ogasawara, K, Saito, T, Lanier, LL, Arase, H	J. Exp. Med.	2004