USP48 cleaves polyubiquitin

Stable Identifier
R-HSA-8862184
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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USP48 (confusingly referred to as USP31 in some literature) is a deubiquitinating enzyme that cleaves preferentially lysine-63-linked polyubiquitin chains. USP48 can also cleave lysine-48-linked polyubiquitin chains albeit to a lesser extent. USP48 can interact with TRAF2, and overexpression of USP48 inhibits NF-?B activation suggesting that it may remove ubiquitin from TRAF2, TRAF6 or another essential intermediate that lies downstream of TRAFs.

Literature References
PubMed ID Title Journal Year
16214042 Human ubiquitin specific protease 31 is a deubiquitinating enzyme implicated in activation of nuclear factor-kappaB

Tzimas, C, Michailidou, G, Arsenakis, M, Kieff, E, Mosialos, G, Hatzivassiliou, EG

Cell. Signal. 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
thiol-dependent ubiquitinyl hydrolase activity of USP48:K63polyUb-TRAF2 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created