Reactome | K63polyUb-TRAF2 [cytosol]

K63polyUb-TRAF2 [cytosol]

Stable Identifier

R-HSA-8862193

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

TNF receptor associated factor 2, Tumor necrosis factor type 2 receptor associated protein 3

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External Reference Information

External Reference

UniProt:Q12933 TRAF2

Gene Names

TRAF2, TRAP3

Chain

initiator methionine:, chain:2-501

Reference Genes

COSMIC (genes):TRAF2 TRAF2

dbSNP Gene:7186 TRAF2

ENSEMBL:ENSG00000127191 TRAF2

Participates

as a member of

K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG [cytosol] (Homo sapiens)

Other forms of this molecule

TRAF2 [cytosol]

PolyUb-TRAF2 [cytosol]

K63polyUb-TRAF2 [nucleoplasm]

TRAF2 [nucleoplasm]

Inferred To

TRAF2 [cytosol] (Bos taurus)

TRAF2 [cytosol] (Canis familiaris)

TRAF2 [cytosol] (Sus scrofa)

traf2b [cytosol] (Danio rerio)

K63polyUb-TRAF2 [cytosol] (Gallus gallus)

Traf2 [cytosol] (Mus musculus)

Traf2 [cytosol] (Rattus norvegicus)

Modified Residues

Name

ubiquitinylated lysine (K63polyUb [cytosol]) at unknown position

Modification

K63polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Interactors (331)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P25942 CD40			0.955	20
UniProt:Q13490 BIRC2	5	BIRC2 [cytosol] (R-HSA-50847) K48pUb-BIRC2 [cytosol] (R-HSA-5675479) BIRC2(373-618) [cytosol] (R-HSA-202931) BIRC2(1-372) [cytosol] (R-HSA-202913) K63polyUb-BIRC2 [cytosol] (R-HSA-5668512)	0.951	19
UniProt:Q15628 TRADD	1	TRADD [cytosol] (R-HSA-66376)	0.942	14
UniProt:Q12933 TRAF2	5	TRAF2 [cytosol] (R-HSA-66370) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199)	0.936	12
UniProt:Q9Y4K3 TRAF6	8	TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [endosome membrane] (R-HSA-450272) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) K48polyUb-TRAF6 [cytosol] (R-HSA-6783233)	0.905	10
UniProt:Q9UHD2 TBK1	5	p-S172-TBK1 [cytosol] (R-HSA-168379) TBK1 [cytosol] (R-HSA-166267) K63polyUb-K30,K401-TBK1 [cytosol] (R-HSA-9730430) p-TBK1 [cytosol] (R-HSA-9008705) pS-172,K48polyUb-TBK1 [cytosol] (R-HSA-3249397)	0.893	9
UniProt:Q13077 TRAF1	3	TRAF1 [cytosol] (R-HSA-5634163) TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.887	14
UniProt:Q13546 RIPK1	20	RIPK1 [cytosol] (R-HSA-168651) RIPK1 [endosome membrane] (R-HSA-450326) K63polyUb-RIPK1 [cytosol] (R-HSA-937021) p-S166-RIPK1 [cytosol] (R-HSA-5218872) p-S357-RIPK1 [cytosol] (R-HSA-9819116) p-S320-RIPK1 [cytosol] (R-HSA-9815498) K63,M1polyUb, p-T189-RIPK1 [cytosol] (R-HSA-9817377) polyUb-K377,K604,K634-RIPK1 [cytosol] (R-HSA-9818391) RIPK1(325-671) [cytosol] (R-HSA-5212671) RIPK1(1-324) [cytosol] (R-HSA-5212664) K63,M1polyUb-RIPK1 [cytosol] (R-HSA-9793681) K63,Met1polyUb-p-S25-RIPK1 [cytosol] (R-HSA-9818793) K48polyUb-K571,K604,K627-RIPK1 [cytosol] (R-HSA-9796639) RIPK1 [plasma membrane] (R-HSA-937073) RIPK1 D324H [cytosol] (R-HSA-9693922) RIPK1 D324V [cytosol] (R-HSA-9693927) RIPK1 D324Y [cytosol] (R-HSA-9693931) RIPK1 D324N [cytosol] (R-HSA-9693930) PolyUb-RIPK1 [cytosol] (R-HSA-6783197) K48polyUb-RIPK1 [cytosol] (R-HSA-6783308)	0.884	10
UniProt:Q13489 BIRC3	3	BIRC3 [cytosol] (R-HSA-50845) K48pUb-BIRC3 [cytosol] (R-HSA-5675478) K63polyUb-BIRC3 [cytosol] (R-HSA-5668478)	0.865	8
UniProt:Q12805 EFEMP1	1	EFEMP1 [extracellular region] (R-HSA-2161393)	0.863	12
UniProt:P54253 ATX1			0.859	14
UniProt:Q92844 TANK	2	K63polyUb-TANK [cytosol] (R-HSA-5362480) TANK [cytosol] (R-HSA-933407)	0.854	10
UniProt:O95999 BCL10	3	K48polyUb-BCL10 [cytosol] (R-HSA-8939329) BCL10 [cytosol] (R-HSA-202447) p-BCL10 [cytosol] (R-HSA-202488)	0.85	11
UniProt:Q96CG3 TIFA	2	TIFA [cytosol] (R-HSA-451582) p-T9-TIFA [cytosol] (R-HSA-9645512)	0.844	13
UniProt:P21580 TNFAIP3	1	TNFAIP3 [cytosol] (R-HSA-688989)	0.831	10
UniProt:P54725 RAD23A	1	RAD23A [nucleoplasm] (R-HSA-5688076)	0.83	8
UniProt:Q9NZD8 SPG21			0.83	8
UniProt:O43741 PRKAB2	2	PRKAB2 [cytosol] (R-HSA-200413) PRKAB2 [nucleoplasm] (R-HSA-164096)	0.83	8
UniProt:Q9BT49 THAP7			0.83	13
UniProt:Q9H8Y8 GORASP2	2	p-T222,T225-GORASP2 [Golgi membrane] (R-HSA-2422965) GORASP2 [Golgi membrane] (R-HSA-2422385)	0.83	8
UniProt:Q6FIF0 ZFAND6	1	ZFAND6 [cytosol] (R-HSA-9033138)	0.809	8
UniProt:P46527 CDKN1B	8	p-T187-CDKN1B [nucleoplasm] (R-HSA-187525) CDKN1B [nucleoplasm] (R-HSA-182563) p-Y88-CDKN1B [nucleoplasm] (R-HSA-8942808) p-Y88-CDKN1B [cytosol] (R-HSA-8848438) CDKN1B [cytosol] (R-HSA-198622) p-T157-CDKN1B [cytosol] (R-HSA-198629) p-S10 CDKN1B [nucleoplasm] (R-HSA-9632832) p-S10 CDKN1B [cytosol] (R-HSA-9632829)	0.799	6
UniProt:P01375 TNF	5	TNF(1-233) [plasma membrane] (R-HSA-66220) TNF(77-233) [extracellular region] (R-HSA-976821) TNF(1-76) [plasma membrane] (R-HSA-8863120) TNF(1-34) [plasma membrane] (R-HSA-8863367) TNF(52-76) [extracellular region] (R-HSA-8863375)	0.788	9
UniProt:O76041 NEBL			0.781	7
UniProt:Q92917 GPKOW	1	GPKOW [nucleoplasm] (R-HSA-8850839)	0.781	7
UniProt:Q13526 PIN1	2	PIN1 [nucleoplasm] (R-HSA-936016) PIN1 [cytosol] (R-HSA-9626823)	0.781	7
UniProt:Q06547 GABPB1			0.781	7
UniProt:Q96JS3 PGBD1			0.781	7
UniProt:Q99618 CDCA3			0.781	7
UniProt:Q9NRN7 AASDHPPT	1	AASDHPPT [cytosol] (R-HSA-199235)	0.781	7
UniProt:O75604 USP2	2	USP2 [cytosol] (R-HSA-5212661) USP2 [nucleoplasm] (R-HSA-5689946)	0.781	7
UniProt:Q9H0I2 ENKD1			0.781	7
UniProt:Q15560 TCEA2			0.781	7
UniProt:Q99558 MAP3K14	5	Active NIK [cytosol] (R-HSA-5607646) MAP3K14 [cytosol] (R-HSA-168189) p-MAP3K14 [cytosol] (R-HSA-168187) K48polyUb-NIK [cytosol] (R-HSA-5668525) p-T559-MAP3K14 [cytosol] (R-HSA-5668531)	0.749	9
UniProt:P19438 TNFRSF1A	2	TNFRSF1A(41-201) [extracellular region] (R-HSA-6785048) TNFRSF1A(30-45) [plasma membrane] (R-HSA-5675738)	0.745	5
UniProt:Q9NVF7 FBX28			0.743	9
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.742	5
UniProt:Q7Z434 MAVS	2	MAVS [mitochondrial outer membrane] (R-HSA-913730) K48polyUb-MAVS [mitochondrial outer membrane] (R-HSA-983463)	0.742	5
UniProt:O60941 DTNB	1	DTNB [plasma membrane] (R-HSA-9630734)	0.742	5
UniProt:Q5T124 UBXN11	1	UBXN11 [cytosol] (R-HSA-9696514)	0.742	5
UniProt:P48380 RFX3			0.742	5
UniProt:Q05516 ZBTB16	1	ZBTB16 [cytosol] (R-HSA-976047)	0.739	5
UniProt:Q8TD31-3 CCHCR1			0.718	8
UniProt:Q5JVL4 EFHC1			0.718	6
UniProt:Q9BXY8 BEX2			0.718	6
UniProt:Q9BXF9 TEKT3			0.718	6
UniProt:Q9BRJ7 TIRR			0.718	6
UniProt:Q9H0W8 SMG9	1	SMG9 [cytosol] (R-HSA-927812)	0.718	6
UniProt:P57682 KLF3			0.718	6
UniProt:O60437 PPL	2	PPL [cytosol] (R-HSA-6810850) PPL [cornified envelope] (R-HSA-8847709)	0.718	6
UniProt:Q6PF18 MORN3			0.718	6
UniProt:Q9BRP7 FDXA1			0.718	6
UniProt:Q0D2K3 RIPP1			0.718	6
UniProt:Q9BSW7 SYT17			0.718	6
UniProt:Q9HC52 CBX8	1	CBX8 [nucleoplasm] (R-HSA-389117)	0.718	6
UniProt:P07947 YES1	2	MyrG-p-Y426-YES1 [plasma membrane] (R-HSA-1810411) YES1 [cytosol] (R-HSA-373640)	0.718	6
UniProt:Q86YD7 F90A1			0.718	6
UniProt:Q02930-3 CREB5			0.718	6
UniProt:Q96IZ5 RBM41			0.718	6
UniProt:Q96NC0 ZMAT2	1	ZMAT2 [nucleoplasm] (R-HSA-9770248)	0.718	6
UniProt:Q99683 MAP3K5	1	MAP3K5 [cytosol] (R-HSA-167709)	0.704	4
UniProt:Q92956 TNFRSF14	1	TNFRSF14 [plasma membrane] (R-HSA-198101)	0.692	3
UniProt:O43353 RIPK2	2	Ub-209-RIPK2 [cytosol] (R-HSA-706483) RIPK2 [cytosol] (R-HSA-168402)	0.688	3
UniProt:P09211 GSTP1	4	GSTP1 [secretory granule lumen] (R-HSA-6801488) GSTP1 [extracellular region] (R-HSA-6806461) GSTP1 [ficolin-1-rich granule lumen] (R-HSA-6801490) GSTP1 [cytosol] (R-HSA-176051)	0.68	5
UniProt:P20333 TNFRSF1B	3	TNFRSF1B(27-?) [plasma membrane] (R-HSA-6785037) TNFRSF1B [specific granule membrane] (R-HSA-6806149) TNFRSF1B [plasma membrane] (R-HSA-5661484)	0.678	4
UniProt:P36941 LTBR	1	LTBR [plasma membrane] (R-HSA-5668750)	0.669	4
UniProt:Q14164 IKBKE	5	IKBKE [cytosol] (R-HSA-450225) p-S172-IKBKE [cytosol] (R-HSA-450278) K63polyUb-K30,K401-IKBKE [cytosol] (R-HSA-9730436) p-S172-IKBKE [nucleoplasm] (R-HSA-4755521) monoSUMO1-K231-p-S172-IKBKE [nucleoplasm] (R-HSA-4755535)	0.669	3
UniProt:Q96EK7 FAM120B	1	FAM120B [nucleoplasm] (R-HSA-8940294)	0.666	4
UniProt:Q12815 TROAP			0.666	5
UniProt:Q8N2X6 EXAS1			0.666	4
UniProt:Q8TBE0 BAHD1			0.666	4
UniProt:Q96IX9 A26L1			0.666	4
UniProt:Q9P2K3 RCOR3			0.666	4
UniProt:P24278 ZBT25			0.666	4
UniProt:X5D778 X5D778			0.666	4
UniProt:Q8N9N5 BANP	1	BANP [nucleoplasm] (R-HSA-3221973)	0.666	4
UniProt:Q6NX49 ZNF544	1	ZNF544 [nucleoplasm] (R-HSA-1973895)	0.666	4
UniProt:Q9UKG1 APPL1	1	APPL1 [endosome membrane] (R-HSA-373630)	0.653	3
UniProt:P63261 ACTG1	3	ACTG1 [plasma membrane] (R-HSA-196044) ACTG1 [lysosomal membrane] (R-HSA-196169) ACTG1 [cytosol] (R-HSA-201858)	0.65	3
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.635	4
UniProt:O75460 ERN1	2	p-S724-ERN1 [endoplasmic reticulum membrane] (R-HSA-381029) ERN1 [endoplasmic reticulum membrane] (R-HSA-381076)	0.628	3
UniProt:O43464 HTRA2	1	HTRA2 [mitochondrial intermembrane space] (R-HSA-56655)	0.615	3
UniProt:P20334	1	Tnfrsf9 [plasma membrane] (R-MMU-5666996)	0.609	2
UniProt:P28908 TNFRSF8	1	TNFRSF8 [plasma membrane] (R-HSA-5668758)	0.59	2
UniProt:Q9Y6Q6 TNFRSF11A	1	TNFRSF11A [plasma membrane] (R-HSA-5668756)	0.589	2
UniProt:P09022 Hoxa1	1	Hoxa1 [nucleoplasm] (R-MMU-5617924)	0.57	3
UniProt:B2R8Y4 B2R8Y4			0.556	3
UniProt:Q9H875 PRKRIP1	1	PRKRIP1 [nucleoplasm] (R-HSA-9769594)	0.556	3
UniProt:Q96JP2 MY15B			0.556	3
UniProt:Q5HYW2 NHSL2			0.556	3
UniProt:P48751 SLC4A3	1	SLC4A3 [plasma membrane] (R-HSA-425360)	0.556	3
UniProt:Q8N6N6 NATD1			0.556	3
UniProt:Q16649 NFIL3	1	NFIL3 [nucleoplasm] (R-HSA-8878899)	0.556	3
UniProt:Q9UHP6 RSP14			0.556	3
UniProt:Q92529 SHC3	2	SHC3 [cytosol] (R-HSA-3006448) p-Y-SHC3 [cytosol] (R-HSA-3009043)	0.556	3
UniProt:P20618 PSMB1	7	PSMB1 [cytosol] (R-HSA-68738) PSMB1 [nucleoplasm] (R-HSA-174347) PSMB1 [secretory granule lumen] (R-HSA-6803287) PSMB1 [extracellular region] (R-HSA-6806477) PSMB1 [ficolin-1-rich granule lumen] (R-HSA-6803340) pro-PSMB1 [cytosol] (R-HSA-9908139) PSMB1(1-28) [cytosol] (R-HSA-9908143)	0.556	5
UniProt:Q01844 EWS			0.556	3
UniProt:Q8NI38 IKBD			0.556	3
UniProt:Q6B0K9 HBM			0.556	3
UniProt:Q5T8A7 PPR26			0.556	3
UniProt:Q08117 TLE5	1	AES [nucleoplasm] (R-HSA-4648963)	0.556	3
UniProt:Q86X59 CQ082			0.556	3
UniProt:Q8IZU1 FAM9A			0.556	3
UniProt:Q14119 VEZF1			0.556	3
UniProt:A0A0S2Z3N6 A0A0S2Z3N6			0.556	3
UniProt:Q14511-2 NEDD9			0.556	3
UniProt:Q16656 NRF1	1	NRF1 [nucleoplasm] (R-HSA-1592205)	0.556	3
UniProt:P53672 CRBA2			0.556	3
UniProt:Q8IYS8 BD1L2			0.556	3
UniProt:Q96HA1-2 POM121			0.556	3
UniProt:Q9BWG6 SCNM1			0.556	3
UniProt:Q9NTX7-2 RNF146			0.556	3
UniProt:P26196 DDX6	1	DDX6 [cytosol] (R-HSA-430032)	0.556	3
UniProt:P51800-3 CLCNKA			0.556	3
UniProt:Q5T5P2-6 KIAA1217			0.556	3
UniProt:Q9UJ78-2 Q9UJ782			0.556	3
UniProt:Q53FD0-2 ZC2HC1C			0.556	3
UniProt:Q07002 CDK18			0.556	3
UniProt:Q8N9N2-2 ASCC1			0.556	3
UniProt:Q14687 GSE1			0.556	3
UniProt:P55040 GEM	1	GEM [plasma membrane] (R-HSA-9769962)	0.556	3
UniProt:P09067 HXB5			0.556	3
UniProt:Q3SY00 T10IP			0.556	3
UniProt:P47897 QARS1	2	QARS [cytosol] (R-HSA-379615) QARS [mitochondrial matrix] (R-HSA-379592)	0.556	3
UniProt:P49711 CTCF	1	CTCF [nucleoplasm] (R-HSA-3782562)	0.556	3
UniProt:Q92997 DVL3	4	pp-DVL3 [cytosol] (R-HSA-3772400) p-DVL3 [cytosol] (R-HSA-201680) DVL3 [cytosol] (R-HSA-201678) ub-DVL3 [cytosol] (R-HSA-4652688)	0.556	3
IntAct:EBI-22620261 CCSB ORF ID			0.556	3
UniProt:Q16512 PKN1	3	p-T774-PKN1 [cytosol] (R-HSA-5623651) PKN1 [cytosol] (R-HSA-5623613) p-T774-PKN1 [nucleoplasm] (R-HSA-5625721)	0.556	3
UniProt:Q2TBE0 CWF19L2	1	CWF19L2 [nucleoplasm] (R-HSA-9770846)	0.556	3
UniProt:Q99633 PRPF18	1	PRPF18 [nucleoplasm] (R-HSA-5688093)	0.556	3
UniProt:Q9UIF8 BAZ2B			0.556	3
UniProt:Q08426 EHHADH	2	EHHADH [peroxisomal matrix] (R-HSA-400155) EHHADH [cytosol] (R-HSA-9033147)	0.556	3
UniProt:Q8IY51 TIGD4			0.556	3
UniProt:Q9GZQ4 NMUR2	1	NMUR2 [plasma membrane] (R-HSA-964816)	0.556	3
UniProt:Q86Y33-5 CDC20B			0.556	3
UniProt:Q8N6R0 EFNMT			0.556	3
UniProt:Q3MJ62 ZSC23			0.556	6
UniProt:Q8WYQ4-2 C22ORF15			0.556	3
UniProt:Q9Y4B4 ARIP4			0.556	3
UniProt:Q9BV90 SNRNP25	1	SNRNP25 [nucleoplasm] (R-HSA-6787847)	0.556	3
UniProt:P13682 ZNF35			0.556	3
UniProt:Q63HK5 TSH3			0.556	3
UniProt:Q9BRR0 ZKSCAN3	1	ZKSCAN3 [nucleoplasm] (R-HSA-1027422)	0.556	3
UniProt:Q86UR1-2 NOXA1			0.556	3
UniProt:O95990-4 FAM107A			0.556	3
UniProt:Q5T619 ZN648			0.556	3
UniProt:Q53FD0 ZC21C			0.556	3
UniProt:P0DTD1-PRO_0000449631 REP			0.556	3
UniProt:Q4V328 GRAP1			0.556	3
IntAct:EBI-10178833 4356			0.556	3
UniProt:P12268 IMPDH2	4	IMPDH2 [secretory granule lumen] (R-HSA-6803323) IMPDH2 [extracellular region] (R-HSA-6806455) IMPDH2 [ficolin-1-rich granule lumen] (R-HSA-6803330) IMPDH2 [cytosol] (R-HSA-57350)	0.556	3
UniProt:Q9C086 INO80B	1	INO80B [nucleoplasm] (R-HSA-5689599)	0.556	3
UniProt:P41225 SOX3	1	SOX3 [nucleoplasm] (R-HSA-5625835)	0.556	3
UniProt:Q9UHB7 AFF4	1	AFF4 [nucleoplasm] (R-HSA-8932788)	0.556	3
UniProt:P35227 PCGF2	1	PCGF2 [nucleoplasm] (R-HSA-389115)	0.556	3
UniProt:Q9NX65 ZSCAN32	1	ZSCAN32 [nucleoplasm] (R-HSA-1247547)	0.556	3
UniProt:Q8N5N6 Q8N5N6			0.556	3
UniProt:Q8NA54 IQUB			0.556	3
UniProt:Q9H5Z6-2 FAM124B			0.556	3
UniProt:Q5T8I9 HENMT1	1	HENMT1 [cytosol] (R-HSA-5601916)	0.556	3
UniProt:P56279 TCL1A			0.556	3
UniProt:Q13671 RIN1	1	RIN1 [cytosol] (R-HSA-8875287)	0.556	3
UniProt:Q9HAK2 EBF2	1	EBF2 [nucleoplasm] (R-HSA-381317)	0.556	3
UniProt:B4DE54 B4DE54			0.556	3
UniProt:Q9BVG8 KIFC3			0.556	3
UniProt:P55081 MFAP1	1	MFAP1 [nucleoplasm] (R-HSA-2396419)	0.556	3
UniProt:Q4VC44 FWCH1			0.556	3
UniProt:G2XKQ0 SUMO5			0.556	3
UniProt:P89055 P89055			0.556	3
UniProt:O95872 GPAN1			0.556	3
UniProt:Q8N9N5-2 BANP			0.556	3
UniProt:O75367 H2AY			0.556	3
UniProt:Q8WWW0 RASF5			0.556	3
UniProt:Q8N9N5-7 BANP			0.556	3
UniProt:Q96MY7 F161B			0.556	3
UniProt:O95994 AGR2			0.556	3
UniProt:Q9H788 SH24A			0.556	3
UniProt:O95995 GAS8	1	GAS8 [cytosol] (R-HSA-5633057)	0.556	3
UniProt:O75808 CAPN15	1	CAPN15 [cytosol] (R-HSA-8848636)	0.556	3
UniProt:Q9BVG8-5 KIFC3			0.556	3
UniProt:Q96CV8 Q96CV8			0.556	3
UniProt:Q8N720 ZNF655	1	ZNF655 [nucleoplasm] (R-HSA-2127575)	0.556	3
UniProt:Q96JC9 EAF1	1	EAF1 [nucleoplasm] (R-HSA-8932787)	0.556	3
UniProt:P49639 HOXA1	1	HOXA1 [nucleoplasm] (R-HSA-5617464)	0.556	3
UniProt:Q15742 NAB2	1	NAB2 [nucleoplasm] (R-HSA-9612177)	0.556	3
UniProt:Q8TAU3 ZNF417	1	ZNF417 [nucleoplasm] (R-HSA-1247539)	0.556	3
UniProt:Q92558 WASF1	3	WASF1 [cytosol] (R-HSA-200965) p-Y151-WASF1 [cytosol] (R-HSA-2029058) p-Y151,S,T-WASF1 [cytosol] (R-HSA-5672390)	0.556	3
UniProt:Q7Z4V0 ZN438			0.556	3
UniProt:Q7L5A3 ATOSB			0.556	3
UniProt:Q96MN9 ZN488			0.556	3
UniProt:A0A0S2Z3V1 A0A0S2Z3V1			0.556	3
UniProt:Q86TN4-2 TRPT1			0.556	3
UniProt:Q86SE9 PCGF5	1	PCGF5 [nucleoplasm] (R-HSA-8937962)	0.556	3
UniProt:Q6ZSB9 ZBT49			0.556	3
UniProt:Q5GFL6 VWA2			0.556	3
UniProt:Q86VK4 ZN410			0.556	3
UniProt:Q9BRU9 UTP23			0.556	3
UniProt:O95863 SNAI1	1	SNAI1 [nucleoplasm] (R-HSA-2980903)	0.556	3
UniProt:O15273 TCAP	1	TCAP [cytosol] (R-HSA-390571)	0.556	3
UniProt:Q8IVT4 Q8IVT4			0.556	3
UniProt:Q8IVT2 MISP			0.556	3
UniProt:Q9GZU8 PIP30			0.556	3
UniProt:Q8NEC5 CATSPER1	1	CATSPER1 [plasma membrane] (R-HSA-2534335)	0.556	3
UniProt:Q13895 BYSL	2	BYSL [nucleoplasm] (R-HSA-6791526) BYSL [cytosol] (R-HSA-6791518)	0.556	3
UniProt:Q53TS8 CTSRT			0.556	3
UniProt:Q15052 ARHGEF6	1	ARHGEF6 [cytosol] (R-HSA-195017)	0.556	3
UniProt:Q7Z5V6-2 SAXO4			0.556	3
UniProt:Q17RB8 LONRF1	1	LONRF1 [cytosol] (R-HSA-8850905)	0.556	3
UniProt:Q9UHB7-2 AFF4			0.556	3
UniProt:Q6BCY4 CYB5R2	1	CYB5R2 [endoplasmic reticulum membrane] (R-HSA-6806861)	0.556	3
UniProt:Q5T7P8-2 SYT6			0.556	3
UniProt:Q9Y3D2 MSRB2	1	MSRB2 [cytosol] (R-HSA-5676906)	0.556	3
UniProt:Q53EP0-3 FNDC3B			0.556	3
UniProt:Q7Z3I7 ZN572			0.556	3
UniProt:E9PSE9 E9PSE9			0.556	3
UniProt:P78317 RNF4	2	RNF4 [nucleoplasm] (R-HSA-5684076) RNF4 [cytosol] (R-HSA-975974)	0.556	3
UniProt:Q9HBE1-4 PATZ1			0.556	3
UniProt:Q96BZ8 LENG1	1	LENG1 [nucleoplasm] (R-HSA-9769590)	0.556	3
UniProt:Q6NYC8 PPR18			0.556	3
UniProt:Q9UBU8-2 MORF4L1			0.556	3
UniProt:Q8WWZ3 EDARADD	1	EDARADD [cytosol] (R-HSA-5675659)	0.556	5
UniProt:Q7KZS0 Q7KZS0			0.556	3
UniProt:P29972 AQP1	1	AQP1 [plasma membrane] (R-HSA-431700)	0.556	3
UniProt:Q86VK4-3 ZNF410			0.556	3
UniProt:Q9Y5U2 TSSC4			0.556	3
UniProt:Q8N8B7-2 TCEANC			0.556	3
UniProt:Q8IV13 CCNJL			0.556	3
UniProt:Q6BCY4-2 CYB5R2			0.556	3
UniProt:Q8IYH5 ZZZ3	1	ZZZ3 [nucleoplasm] (R-HSA-3662283)	0.556	3
IntAct:EBI-22421838 CCSB ORF ID			0.556	3
UniProt:Q96MM6 HSPA12B	2	HSPA12B [cytosol] (R-HSA-5252080) HSPA12B [nucleoplasm] (R-HSA-5252022)	0.556	3
UniProt:Q9Y2J4-4 AMOTL2			0.556	3
UniProt:O60941-5 DTNB			0.556	3
UniProt:P63165 SUMO1	11	lysyl-G97-SUMO1 [nucleoplasm] (R-HSA-9761562) SUMO1(2-101) [nucleoplasm] (R-HSA-2990831) SUMO1 [nucleoplasm] (R-HSA-877304) UBA2-G97-SUMO1 [nucleoplasm] (R-HSA-3730616) UBE2I-G97-SUMO1 [nucleoplasm] (R-HSA-3730622) lysyl-G97-SUMO1 [cytosol] (R-HSA-9762266) lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9762380) UBE2I-G97-SUMO1 [cytosol] (R-HSA-4656941) lysyl-G97-SUMO1 [viral capsid] (R-HSA-9762386) lysyl-G97-SUMO1 [nucleolus] (R-HSA-9762385) lysyl-G97-SUMO1 [plasma membrane] (R-HSA-9762382)	0.556	3
UniProt:Q2TAL8 QRIC1			0.556	3
UniProt:Q8WTU0 DDI1			0.556	3
UniProt:Q9Y6H1 CHCHD2	2	2xHC-CHCHD2 [mitochondrial intermembrane space] (R-HSA-6800100) CHCHD2 [mitochondrial intermembrane space] (R-HSA-1307777)	0.556	3
UniProt:Q6X4W1-2 NSMF			0.556	3
UniProt:O15353 FOXN1			0.556	3
UniProt:Q9Y4C2-2 TCAF1			0.556	3
UniProt:Q96S90 LYSM1			0.556	3
UniProt:Q2KHT4 GSG1			0.556	3
UniProt:P15622-3 ZNF250			0.556	3
UniProt:Q8IXW0 LMTD2			0.556	3
UniProt:Q8NHY3 GA2L2			0.556	3
UniProt:P22415 USF1	2	USF1 [nucleoplasm] (R-HSA-9023562) pT153 USF1 [nucleoplasm] (R-HSA-9855887)	0.556	3
UniProt:Q96PC2 IP6K3	1	IP6K3 [cytosol] (R-HSA-1604594)	0.556	3
UniProt:Q9BUI4 POLR3C	2	POLR3C [cytosol] (R-HSA-1964448) POLR3C [nucleoplasm] (R-HSA-1964430)	0.556	3
UniProt:P57055 DSCR6			0.556	3
UniProt:Q3B820 F161A			0.556	3
UniProt:Q13064 MKRN3			0.556	3
UniProt:Q9NRE2 TSH2			0.556	3
UniProt:A0A0S2Z6P0 A0A0S2Z6P0			0.556	3
UniProt:Q96NU1 SAM11			0.556	3
UniProt:Q8IWZ5 TRI42			0.556	3
UniProt:Q32MK9 Q32MK9			0.556	3
UniProt:Q9HC98-4 NEK6			0.556	3
UniProt:Q9Y247 FA50B			0.556	3
UniProt:Q9UN79 SOX13	1	SOX13 [nucleoplasm] (R-HSA-5627680)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:Q4G0R1 Q4G0R1			0.556	3
UniProt:Q6GPH6-2 ITPRIPL1			0.556	3
UniProt:O43708 GSTZ1	2	GSTZ1 [cytosol] (R-HSA-71165) GSTZ1 [mitochondrial matrix] (R-HSA-9011574)	0.556	3
UniProt:A0A384ME25 A0A384ME25			0.556	3
UniProt:Q86Y33 CD20B			0.556	3
UniProt:P00540 MOS			0.556	3
UniProt:Q5T124-6 UBXN11			0.556	3
UniProt:P35711-4 SOX5			0.556	3
UniProt:Q5TAP6 UTP14C	1	UTP14C [nucleoplasm] (R-HSA-8867818)	0.556	3
UniProt:Q16656-4 NRF1			0.556	3
UniProt:O00233 PSMD9	1	PSMD9 [cytosol] (R-HSA-68810)	0.556	3
UniProt:Q96MP5 ZSWM3			0.556	3
UniProt:O95363 FARS2	1	FARS2(1-?) [mitochondrial matrix] (R-HSA-379565)	0.556	3
IntAct:EBI-10227439 55083			0.556	3
UniProt:P41182 BCL6	1	BCL6 [nucleoplasm] (R-HSA-5223066)	0.556	3
UniProt:Q8N9N2 ASCC1	1	ASCC1 [nucleoplasm] (R-HSA-5656393)	0.556	3
UniProt:Q08495 DMTN	1	DMTN [cytosol] (R-HSA-5216222)	0.556	3
UniProt:Q8IYX8-2 CEP57L1			0.556	3
UniProt:O15169 AXIN1	11	AXIN1 [cytosol] (R-HSA-195249) p-T481,S486,S493-AXIN1 [cytosol] (R-HSA-206040) ub-AXIN1 [cytosol] (R-HSA-4641133) RibC-AXIN1 [cytosol] (R-HSA-3640841) Ub-RibC-AXIN1 [cytosol] (R-HSA-3640864) AXIN1 P255S [cytosol] (R-HSA-5251505) AXIN1 P354L [cytosol] (R-HSA-5251511) AXIN1 W247* [cytosol] (R-HSA-5251512) AXIN1 E406* [cytosol] (R-HSA-5251500) AXIN1 Y346* [cytosol] (R-HSA-4839753) AXIN1 L396M [cytosol] (R-HSA-5251503)	0.556	3
UniProt:Q6ZS27-3 ZNF662			0.556	3
UniProt:O75928-2 PIAS2	1	PIAS2-2 [nucleoplasm] (R-HSA-2993779)	0.556	3
UniProt:Q49AN0 CRY2	4	p-S-CRY2 [cytosol] (R-HSA-400305) p-S-CRY2 [nucleoplasm] (R-HSA-400328) CRY2 [cytosol] (R-HSA-400255) Ub-p-S-CRY2 [nucleoplasm] (R-HSA-517935)	0.556	3
UniProt:Q496Y0 LONF3			0.556	3
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.556	3
UniProt:Q8N3R9 MPP5	2	MPP5 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9689606) MPP5 [plasma membrane] (R-HSA-419969)	0.556	3
UniProt:O00463 TRAF5			0.556	5
UniProt:Q14142 TRIM14	1	TRIM14 [cytosol] (R-HSA-5624345)	0.556	3
UniProt:Q9NVL8 FAME			0.556	3
UniProt:Q9NTX7 RNF146	1	RNF146 [cytosol] (R-HSA-3640827)	0.556	3
UniProt:Q63ZY3 KANK2			0.556	3
UniProt:Q5W5X9-3 TTC23			0.556	3
UniProt:P10599 TXN	4	TXN [cytosol] (R-HSA-66000) 2xHC-TXN [cytosol] (R-HSA-73668) TXN [nucleoplasm] (R-HSA-9617732) 2xHC-TXN [nucleoplasm] (R-HSA-9617733)	0.556	3
UniProt:Q86XT4 TRIM50	1	TRIM50 [cytosol] (R-HSA-5688976)	0.556	3
UniProt:P28676 GCA	2	GCA [extracellular region] (R-HSA-6806174) GCA [azurophil granule lumen] (R-HSA-6799167)	0.556	3
UniProt:Q6ZN55-2 Q6ZN552			0.556	3
UniProt:Q17RL8 Q17RL8			0.556	3
UniProt:A0A0A0MR80 A0A0A0MR80			0.556	3
UniProt:C9JRZ8-2 C9JRZ82			0.556	3
UniProt:O43167 ZBT24			0.556	3
UniProt:Q6NX45 ZNF774	1	ZNF774 [nucleoplasm] (R-HSA-3110232)	0.556	3
UniProt:Q9UM82 SPATA2	1	SPATA2 [cytosol] (R-HSA-9796351)	0.553	2
UniProt:P51116 FXR2			0.553	2
UniProt:Q8IYF1 ELOA2	1	TCEB3B [nucleoplasm] (R-HSA-8867802)	0.553	2
UniProt:Q7Z3B3 KANSL1	1	KANSL1 [nucleoplasm] (R-HSA-3321875)	0.553	2
UniProt:O95990 F107A			0.553	2
UniProt:O43298 ZBT43			0.553	2
UniProt:O14641 DVL2	5	DVL2 [cytosol] (R-HSA-201694) pp-DVL2 [cytosol] (R-HSA-3772398) p-DVL2 [cytosol] (R-HSA-201706) p-DVL2 [clathrin-coated endocytic vesicle] (R-HSA-5138444) ub-DVL2 [cytosol] (R-HSA-4652689)	0.553	2
UniProt:P13994 YJU2B			0.553	2
UniProt:P26842 CD27	1	CD27 [plasma membrane] (R-HSA-5666994)	0.547	3
UniProt:Q13627 DYRK1A	1	DYRK1A [nucleoplasm] (R-HSA-1362267)	0.547	3
UniProt:Q9UKE5 TNIK	1	TNIK [cytosol] (R-HSA-3214889)	0.544	2
UniProt:P88961 MINT-5262024			0.544	3
UniProt:Q13233 MAP3K1	2	MAP3K1 [cytosol] (R-HSA-166866) p-T1400,T1412-MAP3K1 [cytosol] (R-HSA-2685607)	0.536	2
UniProt:P42345 MTOR	2	MTOR [cytosol] (R-HSA-165662) MTOR [nucleoplasm] (R-HSA-5083674)	0.536	2
UniProt:P34931 HSPA1L	2	HSPA1L [nucleoplasm] (R-HSA-5082367) HSPA1L [cytosol] (R-HSA-3371410)	0.536	2
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491)	0.536	2
UniProt:O14836 TNFRSF13B	1	TAC1 [plasma membrane] (R-HSA-5668752)	0.532	3
UniProt:P49841 GSK3B	4	GSK3B [cytosol] (R-HSA-2997551) p-S9-GSK3B [cytosol] (R-HSA-3149577) GSK3B [nucleoplasm] (R-HSA-2022823) GSK3B del304-316 [cytosol] (R-HSA-5339682)	0.527	2
UniProt:Q14790 CASP8	8	CASP8(1-374) [cytosol] (R-HSA-3465404) CASP8(217-374) [mitochondrial outer membrane] (R-HSA-351869) CASP8(385-479) [mitochondrial outer membrane] (R-HSA-351828) CASP8(385-479) [cytosol] (R-HSA-76158) CASP8(375-384) [cytosol] (R-HSA-933460) CASP8(217-374) [cytosol] (R-HSA-75975) CASP8(1-216) [cytosol] (R-HSA-933456) CASP8(1-479) [cytosol] (R-HSA-57031)	0.527	3
UniProt:Q62925	2	MAP3K1 [cytosol] (R-RNO-166866) phospho-p-T1400,T1412-MAP3K1 [cytosol] (R-RNO-2685607)	0.527	2
UniProt:Q9NR28 DIABLO	2	DIABLO [mitochondrial intermembrane space] (R-HSA-64637) DIABLO [cytosol] (R-HSA-114298)	0.527	3
UniProt:Q9H2K8 TAOK3	1	TAOK3 [cytosol] (R-HSA-5423594)	0.524	2
UniProt:O08736 CASPC			0.524	6
UniProt:P07174 Ngfr	8	Tumor necrosis factor receptor superfamily member 16 [plasma membrane] (R-RNO-193863) Ngfr [nucleoplasm] (R-RNO-197473) Ngfr [plasma membrane] (R-RNO-194509) Ngfr [cytosol] (R-RNO-194458) Ngfr [endosome] (R-RNO-209541) Ngfr [plasma membrane] (R-RNO-194476) Ngfr [extracellular region] (R-RNO-194470) Ngfr [plasma membrane] (R-RNO-193664)	0.524	3
UniProt:Q9NP84 TNFRSF12A	1	TNFRSF12A [plasma membrane] (R-HSA-5675666)	0.499	3
UniProt:P70191 TRAF5			0.499	2
UniProt:P03346 GAG			0.488	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	4
UniProt:O14920 IKBKB	3	IKBKB [cytosol] (R-HSA-168114) p-S177,S181-IKBKB [cytosol] (R-HSA-202506) IKBKB Q432Pfs*62 [cytosol] (R-HSA-9628518)	0.483	2
UniProt:Q9Y6Q6-2 TNFRSF11A			0.463	5
UniProt:Q03135 CAV1	5	CAV1 [Golgi membrane] (R-HSA-204504) CAV1 [plasma membrane] (R-HSA-534994) CAV1 [lipid droplet] (R-HSA-163510) CAV1 [endocytic vesicle membrane] (R-HSA-535009) CAV1 [early endosome membrane] (R-HSA-5368451)	0.463	3

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