Reactome | FCHO1 [cytosol]

FCHO1 [cytosol]

Stable Identifier

R-HSA-8862257

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

F-BAR domain only protein 1, FCHO1_HUMAN

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Clathrin-mediated endocytosis (Homo sapiens)
    - AAK1 phosphorylates AP-2 mu subunit at T156 (Homo sapiens)
      - PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Homo sapiens)
        
        FCHO1,2 dimer [cytosol] (Homo sapiens)
        
        FCHO1 dimer [cytosol] (Homo sapiens)
        
        FCHO1 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
        
        FCHO1,2 dimer [cytosol] (Homo sapiens)
        
        FCHO1 dimer [cytosol] (Homo sapiens)
        
        FCHO1 [cytosol] (Homo sapiens)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
        
        FCHO1,2 dimer [cytosol] (Homo sapiens)
        
        FCHO1 dimer [cytosol] (Homo sapiens)
        
        FCHO1 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
        
        FCHO1,2 dimer [cytosol] (Homo sapiens)
        
        FCHO1 dimer [cytosol] (Homo sapiens)
        
        FCHO1 [cytosol] (Homo sapiens)
    - Cargo recognition for clathrin-mediated endocytosis (Homo sapiens)
      - ARBB recruits GPCRs into clathrin-coated pits (Homo sapiens)
        
        ARBBs:ARBB-binding GPCRs:clathrin-coated pit [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
        
        FCHO1,2 dimer [cytosol] (Homo sapiens)
        
        FCHO1 dimer [cytosol] (Homo sapiens)
        
        FCHO1 [cytosol] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
        
        FCHO1,2 dimer [cytosol] (Homo sapiens)
        
        FCHO1 dimer [cytosol] (Homo sapiens)
        
        FCHO1 [cytosol] (Homo sapiens)
    - Clathrin recruits PIK3C2A (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
        
        FCHO1,2 dimer [cytosol] (Homo sapiens)
        
        FCHO1 dimer [cytosol] (Homo sapiens)
        
        FCHO1 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
        
        FCHO1,2 dimer [cytosol] (Homo sapiens)
        
        FCHO1 dimer [cytosol] (Homo sapiens)
        
        FCHO1 [cytosol] (Homo sapiens)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
        
        FCHO1,2 dimer [cytosol] (Homo sapiens)
        
        FCHO1 dimer [cytosol] (Homo sapiens)
        
        FCHO1 [cytosol] (Homo sapiens)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Homo sapiens)
      - FCHO1,2 dimer [cytosol] (Homo sapiens)
        
        FCHO1 dimer [cytosol] (Homo sapiens)
        
        FCHO1 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
        
        FCHO1,2 dimer [cytosol] (Homo sapiens)
        
        FCHO1 dimer [cytosol] (Homo sapiens)
        
        FCHO1 [cytosol] (Homo sapiens)
    - FCHo proteins bind nascent clathrin-coated pit (Homo sapiens)
      - FCHO1,2 dimer [cytosol] (Homo sapiens)
        
        FCHO1 dimer [cytosol] (Homo sapiens)
        
        FCHO1 [cytosol] (Homo sapiens)
      - PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Homo sapiens)
        
        FCHO1,2 dimer [cytosol] (Homo sapiens)
        
        FCHO1 dimer [cytosol] (Homo sapiens)
        
        FCHO1 [cytosol] (Homo sapiens)
    - Recruitment of AP-2 complex and clathrin (Homo sapiens)
      - PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Homo sapiens)
        
        FCHO1,2 dimer [cytosol] (Homo sapiens)
        
        FCHO1 dimer [cytosol] (Homo sapiens)
        
        FCHO1 [cytosol] (Homo sapiens)
      - PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Homo sapiens)
        
        FCHO1,2 dimer [cytosol] (Homo sapiens)
        
        FCHO1 dimer [cytosol] (Homo sapiens)
        
        FCHO1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O14526 FCHO1

Gene Names

FCHO1, KIAA0290

Chain

chain:1-889

Reference Genes

BioGPS Gene:23149 FCHO1

COSMIC (genes):FCHO1 FCHO1

CTD Gene:23149 FCHO1

dbSNP Gene:23149 FCHO1

ENSEMBL:ENSG00000130475 FCHO1

HGNC:29002 FCHO1

Monarch:23149 FCHO1

NCBI Gene:23149 FCHO1

OMIM:613437 FCHO1

UCSC:O14526 FCHO1

Reference Transcript

Other Identifiers

11725194_a_at

16859611

213669_PM_at

213669_at

23149

3824541

3824542

3824543

3824544

3824545

3824546

3824547

3824548

3824549

3824550

3824551

3824552

3824553

3824554

3824555

3824556

3824557

3824558

3824559

3824560

3824561

3824562

3824563

3824564

3824565

3824566

3824567

3824568

3824569

3824570

3824571

3824572

3824573

3824574

3824576

3824577

3824578

3824579

3824580

3824581

3824582

3824583

3824589

3824595

41054_at

8026830

A_14_P102432

A_32_P459533

A_33_P3255509

GE53134

GO:0002376

GO:0005515

GO:0005654

GO:0005737

GO:0005829

GO:0005886

GO:0005905

GO:0006897

GO:0016192

GO:0035612

GO:0048268

GO:0050852

GO:0050870

GO:0065003

GO:0072583

GO:0098843

HMNXSV003052427

Hs.96485.0.S1_3p_at

Hs.96485.0.S1_3p_x_at

ILMN_1654571

PH_hs_0005235

TC19000342.hg

Participates

as a component of

FCHO1 dimer [cytosol] (Homo sapiens)

Inferred To

mgp1 [cytosol] (Dictyostelium discoideum)

rga9 [cytosol] (Schizosaccharomyces pombe)

SYP1 [cytosol] (Saccharomyces cerevisiae)

Dmel\CG8176 [cytosol] (Drosophila melanogaster)

FCHO1 [cytosol] (Bos taurus)

FCHO1 [cytosol] (Canis familiaris)

FCHO1 [cytosol] (Dictyostelium discoideum)

FCHO1 [cytosol] (Gallus gallus)

FCHO1 [cytosol] (Sus scrofa)

fcho-1 [cytosol] (Caenorhabditis elegans)

imp2 [cytosol] (Schizosaccharomyces pombe)

Fcho1 [cytosol] (Mus musculus)

Fcho1 [cytosol] (Rattus norvegicus)

cdc15 [cytosol] (Schizosaccharomyces pombe)

Homologues of FCHO1 [cytosol] (Dictyostelium discoideum)

Homologues of FCHO1 [cytosol] (Saccharomyces cerevisiae)

Homologues of FCHO1 [cytosol] (Schizosaccharomyces pombe)

RGD2 [cytosol] (Saccharomyces cerevisiae)

syp1 [cytosol] (Schizosaccharomyces pombe)

rga8 [cytosol] (Schizosaccharomyces pombe)

HOF1 [cytosol] (Saccharomyces cerevisiae)

Cross References

OpenTargets

ENSG00000130475

ENSEMBL

ENSP00000514179, ENSP00000514211, ENST00000595033, ENSP00000514180, ENST00000596536, ENSP00000469075, ENSP00000472668, ENSP00000472417, ENSP00000470731, ENST00000596951, ENSP00000470511, ENST00000600209, ENST00000699215, ENST00000699207, ENST00000600676, ENST00000699209, ENSP00000514206, ENST00000699177, ENST00000699176, ENST00000596309, ENSP00000470493, ENSP00000514204

HPA

ENSG00000130475-FCHO1

PRO

O14526

Pharos - Targets

O14526

Orphanet

FCHO1

GlyGen

O14526

PDB

7OHI

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NQT4 EXOSC5	2	EXOSC5 [cytosol] (R-HSA-429889) EXOSC5 [nucleoplasm] (R-HSA-6791550)	0.666	4
UniProt:Q13882 PTK6	5	PTK6 [cytosol] (R-HSA-8848000) p-Y342-PTK6 [cytosol] (R-HSA-8848007) p-Y342-PTK6 [nucleoplasm] (R-HSA-8848937) p-Y351-PTK6 [cytosol] (R-HSA-8857570) p-Y342,Y447-PTK6 [cytosol] (R-HSA-8849103)	0.666	4

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