Many pathogens such as Streptococcus pneumoniae have evolved lysozyme resistance to prevent peptidoglycan hydrolysis. The primary mechanism for lysozyme resistance in both Gram-positive and Gram-negative organisms appears to be direct modification of peptidoglycan; however, modification of other cell wall-linked components, such as teichoic acid, may also contribute to resistance (Amano K & Williams JC 1983; Bera A et al. 2005; Pushkaran AC et al. 2015).
LYZ is found in many human secretions such as tears, milk, mucus and saliva (Surna A et al. 2009; Minami J et al. 2015; Sahin O et al. 2016; Masschalck B & Michiels CW. 2003).
Assaf, Y, Sharon, N, Chipman, DM, Schindler, M
Jonaitis, J, Sakalauskiene, J, Surna, A, Vitkauskiene, A, Gleiznys, A, Saferis, V, Kubilius, R
lysozyme activity of LYZ:PGN [extracellular region]
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