Reactome | ANXA5 [cytosol]

ANXA5 [cytosol]

Stable Identifier

R-HSA-8862945

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Annexin A5, ANXA5_HUMAN

Locations in the PathwayBrowser

Expand all

Hemostasis (Homo sapiens)

- Platelet activation, signaling and aggregation (Homo sapiens)
  - Response to elevated platelet cytosolic Ca2+ (Homo sapiens)
    - Platelet degranulation (Homo sapiens)
      - Release of platelet cytosolic components (Homo sapiens)
        
        Platelet releasate cytosolic proteins [cytosol] (Homo sapiens)
        
        ANXA5 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P08758 ANXA5

Gene Names

ANXA5, ANX5, ENX2, PP4

Chain

initiator methionine:, chain:2-320

Reference Genes

BioGPS Gene:308 ANXA5

COSMIC (genes):ANXA5 ANXA5

CTD Gene:308 ANXA5

dbSNP Gene:308 ANXA5

ENSEMBL:ENSG00000164111 ANXA5

ENSEMBL_homo_sapiens_GENE:ENSG00000164111.15 ANXA5

HGNC:543 ANXA5

KEGG Gene (Homo sapiens):308 ANXA5

Monarch:308 ANXA5

NCBI Gene:308 ANXA5

OMIM:131230 ANXA5

Reference Transcript

RefSeq:NM_001154.3 ANXA5

Other Identifiers

11743033_x_at

11750040_a_at

11750041_s_at

11750042_x_at

11756245_s_at

11759424_at

16979482

200782_PM_at

200782_at

2784036

2784037

2784038

2784039

2784040

2784041

2784045

2784046

2784047

2784049

2784050

2784057

2784059

2784060

2784064

2784065

2784066

2784068

2784070

2784072

308

37747_at

8102619

A_23_P69720

GE57487

GE58246

GO:0001786

GO:0004859

GO:0005509

GO:0005515

GO:0005543

GO:0005544

GO:0005576

GO:0005615

GO:0005737

GO:0005829

GO:0005886

GO:0005925

GO:0007165

GO:0007596

GO:0007599

GO:0008289

GO:0009897

GO:0010033

GO:0012501

GO:0016020

GO:0023052

GO:0030312

GO:0031012

GO:0042060

GO:0042383

GO:0043066

GO:0043226

GO:0050819

GO:0062023

GO:0070062

GO:0072563

GO:0098772

HMNXSV003045131

ILMN_1741003

PH_hs_0022607

TC04001514.hg

TC04002701.hg

U01691_s_at

g4809273_3p_at

Participates

as a member of

Platelet releasate cytosolic proteins [cytosol] (Homo sapiens)

Other forms of this molecule

ANXA5 [extracellular region]

Inferred To

AnxB10 [cytosol] (Drosophila melanogaster)

anxa5b [cytosol] (Danio rerio)

Homologues of ANXA5 [cytosol] (Dictyostelium discoideum)

anxa5 [cytosol] (Xenopus tropicalis)

nxnB [cytosol] (Dictyostelium discoideum)

Anxa5 [cytosol] (Mus musculus)

Anxa5 [cytosol] (Rattus norvegicus)

ANXA5 [cytosol] (Bos taurus)

ANXA5 [cytosol] (Canis familiaris)

ANXA5 [cytosol] (Gallus gallus)

ANXA5 [cytosol] (Sus scrofa)

nxnA [cytosol] (Dictyostelium discoideum)

Cross References

RefSeq

NP_001145.1

OpenTargets

ENSG00000164111

HPA

ENSG00000164111-ANXA5

GeneCards

P08758

Ensembl

ENSP00000296511, ENSG00000164111, ENST00000296511

PRO

P08758

Pharos - Targets

P08758

HMDB Protein

HMDBP02106

PDB

1HVE, 1AVR, 2XO2, 2XO3, 8H0J, 8GYC, 1HAK, 1ANW, 6K22, 1HVF, 1HVG, 1AVH, 1SAV, 1ANX, 8H9Z, 1HVD, 6K25

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96CV9 OPTN	6	OPTN [recycling endosome membrane] (R-HSA-8854141) p-S177-OPTN [nucleoplasm] (R-HSA-2562595) p-S177-OPTN [cytosol] (R-HSA-2562525) OPTN [Golgi membrane] (R-HSA-2161111) OPTN [cytosol] (R-HSA-9687907) p-S177,S473,S513-OPTN [cytosol] (R-HSA-9687840)	0.556	3
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:P04792 HSBP1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.556	3
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	8

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