Influx of extracellular calcium

Stable Identifier
R-HSA-8863009
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Beta amyloid increases influx of extracellular calcium (Ca2+) through the plasma membrane, thus increasing the cytosolic Ca2+ concentration. The mechanism has not been completely elucidated (Lee et al. 2000, Abramov et al. 2004).

Literature References
PubMed ID Title Journal Year
10830966 Neurotoxicity induces cleavage of p35 to p25 by calpain

Lee, MS, Kwon, YT, Li, M, Peng, J, Friedlander, RM, Tsai, LH

Nature 2000
15590058 Calcium signals induced by amyloid beta peptide and their consequences in neurons and astrocytes in culture

Abramov, AY, Canevari, L, Duchen, MR

Biochim. Biophys. Acta 2004
Participants
Participant Of
This entity is regulated by
Disease
Name Identifier Synonyms
Alzheimer's disease 10652 AD, Alzheimers dementia, Alzheimer disease
Authored