p25-bound CDK5 phosphorylates CDC25C

Stable Identifier
R-HSA-8863011
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

CDK5 activated by binding to p25 phosphorylates CDC25C protein tyrosine phosphatase at serine and threonine residues T48, T67, S122, T130, S168, and S214. CDK5-mediated phosphorylation of CDC25C interferes with 14-3-3-epsilon (YWHAE) mediated retention of CDC25C in the cytosol. Once activated by CDK5, CDC25C promotes activation of CDK1 (Chang et al. 2012).

Literature References
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of CDK5:p25 [cytosol]
Physical Entity
Activity
Disease
Name Identifier Synonyms
Alzheimer's disease 10652 AD, Alzheimers dementia, Alzheimer disease