p25-bound CDK5 phosphorylates CDC25A

Stable Identifier
R-HSA-8863014
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

CDK5, activated by binding to p25, phosphorylates CDC25A protein tyrosine phosphatase at serine residues S40, S116 and S261. CDC25A mainly localizes to the nucleus in neurons and CDK5-mediated phosphorylation does not change its localization. Once activated by CDK5, CDC25A promotes activation of CDK1, CDK2 and CDK4 (Chang et al. 2012).

Literature References
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of CDK5:p25 [nucleoplasm]
Physical Entity
Activity
Disease
Name Identifier Synonyms
Alzheimer's disease 10652 AD, Alzheimers dementia, Alzheimer disease