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PREX1 [cytosol]
Stable Identifier
R-HSA-8863083
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein, PREX1_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
Cell death signalling via NRAGE, NRIF and NADE (Homo sapiens)
NRAGE signals death through JNK (Homo sapiens)
p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Homo sapiens)
GEFs [cytosol] (Homo sapiens)
PREX1 [cytosol] (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (12/13) signalling events (Homo sapiens)
GEFs activate RhoA,B,C (Homo sapiens)
GEFs [cytosol] (Homo sapiens)
PREX1 [cytosol] (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
CDC42 GTPase cycle (Homo sapiens)
CDC42 GEFs activate CDC42 (Homo sapiens)
CDC42 GEFs [cytosol] (Homo sapiens)
PREX1 [cytosol] (Homo sapiens)
RAC1 GTPase cycle (Homo sapiens)
RAC1 GEFs activate RAC1 (Homo sapiens)
RAC1 GEFs [cytosol] (Homo sapiens)
PREX1 [cytosol] (Homo sapiens)
RAC2 GTPase cycle (Homo sapiens)
RAC2 GEFs activate RAC2 (Homo sapiens)
RAC2 GEFs [cytosol] (Homo sapiens)
PREX1 [cytosol] (Homo sapiens)
RAC3 GTPase cycle (Homo sapiens)
RAC3 GEFs activate RAC3 (Homo sapiens)
RAC3 GEFs [cytosol] (Homo sapiens)
PREX1 [cytosol] (Homo sapiens)
RHOA GTPase cycle (Homo sapiens)
RHOA GEFs activate RHOA (Homo sapiens)
RHOA GEFs [cytosol] (Homo sapiens)
PREX1 [cytosol] (Homo sapiens)
RHOB GTPase cycle (Homo sapiens)
RHOB GEFs activate RHOB (Homo sapiens)
RHOB GEFs [cytosol] (Homo sapiens)
PREX1 [cytosol] (Homo sapiens)
RHOC GTPase cycle (Homo sapiens)
RHOC GEFs activate RHOC (Homo sapiens)
RHOC GEFs [cytosol] (Homo sapiens)
PREX1 [cytosol] (Homo sapiens)
RHOG GTPase cycle (Homo sapiens)
RHOG GEFs activate RHOG (Homo sapiens)
RHOG GEFs [cytosol] (Homo sapiens)
PREX1 [cytosol] (Homo sapiens)
RHOJ GTPase cycle (Homo sapiens)
RHOJ GEFs activate RHOJ (Homo sapiens)
RHOJ GEFs [cytosol] (Homo sapiens)
PREX1 [cytosol] (Homo sapiens)
RHOQ GTPase cycle (Homo sapiens)
RHOQ GEFs activate RHOQ (Homo sapiens)
RHOQ GEFs [cytosol] (Homo sapiens)
PREX1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8TCU6 PREX1
Gene Names
PREX1, KIAA1415
Chain
chain:1-1659
Reference Genes
BioGPS Gene:57580 PREX1
COSMIC (genes):PREX1 PREX1
CTD Gene:57580 PREX1
dbSNP Gene:57580 PREX1
ENSEMBL:ENSG00000124126 PREX1
HGNC:32594 PREX1
KEGG:hsa:57580 PREX1
Monarch:57580 PREX1
NCBI Gene:57580 PREX1
OMIM:606905 PREX1
UCSC:Q8TCU6 PREX1
Reference Transcript
RefSeq:NM_020820.3 PREX1
Other Identifiers
11716848_a_at
11716849_s_at
16920047
224909_PM_s_at
224909_s_at
224925_PM_at
224925_at
3908632
3908633
3908634
3908635
3908636
3908637
3908638
3908640
3908643
3908644
3908645
3908646
3908647
3908648
3908649
3908650
3908652
3908654
3908656
3908657
3908658
3908659
3908660
3908662
3908663
3908664
3908665
3908666
3908667
3908668
3908669
3908670
3908671
3908672
3908673
3908675
3908676
3908677
3908678
3908679
3908680
3908683
3908684
3908685
3908691
3908692
3908693
3908694
3908697
3908698
3908700
3908701
3908706
3908707
3908729
3908730
56420_at
57580
8066848
GE53958
GO:0002376
GO:0005085
GO:0005096
GO:0005515
GO:0005543
GO:0005737
GO:0005829
GO:0005886
GO:0006801
GO:0007186
GO:0008289
GO:0019899
GO:0023051
GO:0030041
GO:0030154
GO:0030217
GO:0030335
GO:0030426
GO:0030593
GO:0030833
GO:0035556
GO:0042119
GO:0043198
GO:0045785
GO:0048471
GO:0048870
GO:0050773
GO:0051056
GO:0065003
GO:0072593
GO:0098772
GO:1900026
HMNXSV003055293
Hs.109315.1.S1_3p_a_at
Hs.109315.1.S2_3p_at
ILMN_1777342
PH_hs_0025589
TC20000920.hg
p33805
Participates
as a candidate of
RHOA GEFs [cytosol] (Homo sapiens)
CDC42 GEFs [cytosol] (Homo sapiens)
RHOJ GEFs [cytosol] (Homo sapiens)
as a member of
RHOC GEFs [cytosol] (Homo sapiens)
RAC2 GEFs [cytosol] (Homo sapiens)
RAC1 GEFs [cytosol] (Homo sapiens)
RHOB GEFs [cytosol] (Homo sapiens)
RHOG GEFs [cytosol] (Homo sapiens)
RAC3 GEFs [cytosol] (Homo sapiens)
RHOQ GEFs [cytosol] (Homo sapiens)
GEFs [cytosol] (Homo sapiens)
Inferred To
PREX1 [cytosol]
(Bos taurus)
PREX1 [cytosol]
(Canis familiaris)
PREX1 [cytosol]
(Gallus gallus)
PREX1 [cytosol]
(Sus scrofa)
Prex1 [cytosol]
(Mus musculus)
Prex1 [cytosol]
(Rattus norvegicus)
prex1 [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_065871.2
ENSEMBL
ENST00000371941
,
ENSP00000361009
OpenTargets
ENSG00000124126
HPA
ENSG00000124126-PREX1
PRO
Q8TCU6
Pharos - Targets
Q8TCU6
GlyGen
Q8TCU6
HMDB Protein
HMDBP07343
PDB
3QIK
,
8TUA
,
4YON
,
5D3X
,
5D27
,
5D3Y
,
7RX9
,
5FI0
,
5FI1
,
5D3W
,
5D3V
,
6PCV
,
6VSK
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P08581 MET
7
p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane]
(R-HSA-6806973)
MET [plasma membrane]
(R-HSA-419603)
p-Y1003,4Y-MET [plasma membrane]
(R-HSA-8874689)
p-Y1234,Y1235,Y1356-MET [plasma membrane]
(R-HSA-6807014)
MonoUb-K,p-Y1003,4Y-MET [plasma membrane]
(R-HSA-8875180)
MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane]
(R-HSA-8875181)
p-Y1349,Y1356-MET [plasma membrane]
(R-HSA-6807032)
0.524
2
UniProt:P31750 Akt1
12
phospho-p-T308,S473-AKT1 [nucleoplasm]
(R-MMU-198357)
phospho-p-T308,S473-AKT1 [cytosol]
(R-MMU-198356)
phospho-p-S473-AKT1 [plasma membrane]
(R-MMU-377265)
AKT1 [plasma membrane]
(R-MMU-199416)
AKT1 [cytosol]
(R-MMU-58252)
phospho-p-T308-AKT1 [cytosol]
(R-MMU-198634)
phospho-p-Y315,Y326-AKT1 [cytosol]
(R-MMU-8848757)
phospho-p-T308,S473-AKT1 [plasma membrane]
(R-MMU-199430)
p-T308,S473-Akt1 [cytosol]
(R-MMU-162346)
Akt1 [cytosol]
(R-MMU-189709)
phospho-p-S473-AKT1 [cytosol]
(R-MMU-9841264)
p-T308,S473-Akt1 [plasma membrane]
(R-MMU-1445123)
0.499
2
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