Reactome | TNF(1-76) [plasma membrane]

TNF(1-76) [plasma membrane]

Stable Identifier

R-HSA-8863120

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Icon

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P01375 TNF

Gene Names

TNF, TNFA, TNFSF2

Chain

chain:1-233, chain:1-39, chain:1-35, chain:50-, chain:52-, chain:77-233

Reference Genes

BioGPS Gene:7124 TNF

COSMIC (genes):TNF TNF

CTD Gene:7124 TNF

dbSNP Gene:7124 TNF

ENSEMBL:ENSG00000204490 TNF

ENSEMBL:ENSG00000206439 TNF

ENSEMBL:ENSG00000223952 TNF

ENSEMBL:ENSG00000228321 TNF

ENSEMBL:ENSG00000228849 TNF

ENSEMBL:ENSG00000230108 TNF

ENSEMBL:ENSG00000232810 TNF

HGNC:11892 TNF

KEGG Gene (Homo sapiens):7124 TNF

Monarch:7124 TNF

NCBI Gene:7124 TNF

OMIM:191160 TNF

Reference Transcript

RefSeq:NM_000594.3 TNF

Other Identifiers

0002450619

11721577_at

17006659

17026267

17027794

17030620

17033337

17035418

17038117

17040712

1852_at

207113_s_at

259_s_at

2902417

2902418

2902420

2902421

2902423

2902424

7124

8118142

8177983

8179263

A_14_P110091

A_14_P125975

A_23_P376488

A_24_P50759

GE59636

GO:0000122

GO:0000165

GO:0000185

GO:0000187

GO:0000278

GO:0000976

GO:0001774

GO:0001819

GO:0001891

GO:0001932

GO:0001934

GO:0001937

GO:0002020

GO:0002376

GO:0002439

GO:0002719

GO:0002876

GO:0002925

GO:0003674

GO:0003677

GO:0005125

GO:0005164

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005768

GO:0005886

GO:0005887

GO:0005975

GO:0006006

GO:0006357

GO:0006412

GO:0006464

GO:0006629

GO:0006810

GO:0006919

GO:0006950

GO:0006952

GO:0006954

GO:0006955

GO:0006959

GO:0007010

GO:0007049

GO:0007155

GO:0007165

GO:0007249

GO:0007254

GO:0007267

GO:0007275

GO:0008150

GO:0008219

GO:0008283

GO:0008625

GO:0008630

GO:0009056

GO:0009058

GO:0009615

GO:0009651

GO:0009790

GO:0009887

GO:0009897

GO:0009986

GO:0010033

GO:0010573

GO:0010628

GO:0010629

GO:0010693

GO:0010803

GO:0010888

GO:0014068

GO:0015031

GO:0016020

GO:0016021

GO:0016192

GO:0019221

GO:0019899

GO:0022607

GO:0030154

GO:0030198

GO:0030316

GO:0030730

GO:0030866

GO:0031327

GO:0031334

GO:0031410

GO:0031622

GO:0031663

GO:0032603

GO:0032715

GO:0032722

GO:0032729

GO:0032731

GO:0032755

GO:0032757

GO:0032800

GO:0033138

GO:0033209

GO:0034116

GO:0034330

GO:0034641

GO:0035509

GO:0040011

GO:0042127

GO:0042531

GO:0042592

GO:0042742

GO:0042802

GO:0043065

GO:0043068

GO:0043122

GO:0043123

GO:0043154

GO:0043226

GO:0043242

GO:0043243

GO:0043280

GO:0043406

GO:0043491

GO:0043507

GO:0043525

GO:0043537

GO:0044281

GO:0044403

GO:0045071

GO:0045080

GO:0045121

GO:0045123

GO:0045429

GO:0045598

GO:0045599

GO:0045662

GO:0045668

GO:0045670

GO:0045672

GO:0045732

GO:0045785

GO:0045860

GO:0045892

GO:0045893

GO:0045930

GO:0045944

GO:0045994

GO:0046325

GO:0046330

GO:0046427

GO:0048143

GO:0048566

GO:0048646

GO:0048661

GO:0048856

GO:0048870

GO:0050708

GO:0050715

GO:0050727

GO:0050729

GO:0050766

GO:0050768

GO:0050796

GO:0050806

GO:0050807

GO:0050830

GO:0050877

GO:0050890

GO:0050900

GO:0050901

GO:0050995

GO:0051000

GO:0051023

GO:0051044

GO:0051091

GO:0051092

GO:0051173

GO:0051222

GO:0051384

GO:0051798

GO:0051897

GO:0051966

GO:0055037

GO:0055085

GO:0060252

GO:0060557

GO:0060559

GO:0060664

GO:0060693

GO:0061044

GO:0061048

GO:0065003

GO:0070374

GO:0070886

GO:0071222

GO:0071230

GO:0071316

GO:0071407

GO:0071550

GO:0071677

GO:0071803

GO:0072577

GO:0072659

GO:0097190

GO:0097191

GO:0097527

GO:0150078

GO:0150129

GO:1900017

GO:1900222

GO:1901224

GO:1901647

GO:1901671

GO:1902004

GO:1902895

GO:1903078

GO:1903140

GO:1903347

GO:1903721

GO:1903799

GO:1904707

GO:1904996

GO:1904999

GO:2000010

GO:2000304

GO:2000334

GO:2000343

GO:2000351

GO:2000377

GO:2001234

GO:2001238

GO:2001240

ILMN_1728106

PH_hs_0012958

TC06000371.hg

TC06002714.hg

TC6_apd_hap1000036.hg

TC6_cox_hap2000067.hg

TC6_dbb_hap3000058.hg

TC6_mann_hap4000059.hg

TC6_mcf_hap5000053.hg

TC6_qbl_hap6000058.hg

TC6_ssto_hap7000054.hg

X02910_at

g10835154_3p_a_at

Participant Of

hasComponent

TNF(1-76) trimer [plasma membrane]

Other forms of this molecule

TNF(52-76) [extracellular region]

TNF(1-34) [plasma membrane]

TNF(77-233) [extracellular region]

TNF(1-233) [plasma membrane]

Inferred To

tnfsf10 [plasma membrane] (Danio rerio)

TNF(1-76) [plasma membrane] (Bos taurus)

TNF(1-76) [plasma membrane] (Xenopus tropicalis)

TNF [plasma membrane] (Canis familiaris)

TNF [plasma membrane] (Sus scrofa)

tnfsf10l4 [plasma membrane] (Danio rerio)

tnfsf11 [plasma membrane] (Danio rerio)

Homologues of TNF(1-76) [plasma membrane] (Danio rerio)

Tnf [plasma membrane] (Mus musculus)

Tnf [plasma membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_000585.2

ZINC - World Drugs

TNFA_HUMAN

OpenTargets

ENSG00000232810

ZINC - Substances

TNFA_HUMAN

ZINC target

P01375

ZINC - Biogenic

TNFA_HUMAN

PRO

P01375

PDB

5TSW, 6OP0, 6OOY, 4G3Y, 3L9J, 6OOZ, 6RMJ, 5M2I, 5MU8, 5WUX, 2AZ5, 5M2J, 3WD5, 2ZJC, 5YOY, 1TNF, 5M2M, 1A8M, 3IT8, 2E7A, 4TSV, 4TWT, 2TUN, 2ZPX, 5UUI, 4Y6O, 3ALQ

ZINC - Investigational

TNFA_HUMAN

ZINC - Metabolites

TNFA_HUMAN

GeneCards

P01375

HPA

ENSG00000232810-TNF

Ensembl

ENSP00000372988, ENSP00000398698, ENSP00000410668, ENSG00000228849, ENSG00000223952, ENST00000376122, ENST00000420425, ENSP00000389492, ENST00000383496, ENST00000448781, ENSG00000232810, ENSP00000389490, ENSG00000230108, ENSP00000392858, ENST00000449264, ENST00000443707, ENSG00000204490, ENSP00000365290, ENSG00000228321, ENSG00000206439, ENST00000412275

ZINC - Predictions - Purchasable

TNFA_HUMAN

Orphanet

16877

HMDB Protein

HMDBP02070

Interactors (51)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P19438 TNFRSF1A	3	TNFRSF1A [plasma membrane] (R-HSA-5675738) TNFRSF1A(41-201) [extracellular region] (R-HSA-6785048) TNFRSF1A(22-455) [plasma membrane] (R-HSA-66344)	0.937	15
UniProt:Q13546 RIPK1	14	PolyUb-RIPK1 [cytosol] (R-HSA-6783197) K48polyUb-RIPK1 [cytosol] (R-HSA-6783308) RIPK1 D324N [cytosol] (R-HSA-9693930) RIPK1 D324Y [cytosol] (R-HSA-9693931) RIPK1 D324V [cytosol] (R-HSA-9693927) RIPK1 D324H [cytosol] (R-HSA-9693922) RIPK1 [plasma membrane] (R-HSA-937073) K63pUb-K377-RIP1 [cytosol] (R-HSA-5212672) RIPK1(1-324) [cytosol] (R-HSA-5212664) RIPK1(325-671) [cytosol] (R-HSA-5212671) p-S166-RIPK1 [cytosol] (R-HSA-5218872) RIPK1 [endosome membrane] (R-HSA-450326) K63polyUb-RIPK1 [cytosol] (R-HSA-937021) RIPK1 [cytosol] (R-HSA-168651)	0.837	9
UniProt:Q12933 TRAF2	5	K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.788	9
UniProt:Q13490 BIRC2	5	K48pUb-BIRC2 [cytosol] (R-HSA-5675479) K63polyUb-BIRC2 [cytosol] (R-HSA-5668512) BIRC2(1-372) [cytosol] (R-HSA-202913) BIRC2(373-618) [cytosol] (R-HSA-202931) BIRC2 [cytosol] (R-HSA-50847)	0.788	5
UniProt:P01375 TNF	5	TNF(1-34) [plasma membrane] (R-HSA-8863367) TNF(52-76) [extracellular region] (R-HSA-8863375) TNF(1-76) [plasma membrane] (R-HSA-8863120) TNF(77-233) [extracellular region] (R-HSA-976821) TNF(1-233) [plasma membrane] (R-HSA-66220)	0.73	3
UniProt:Q15628 TRADD	1	TRADD [cytosol] (R-HSA-66376)	0.725	7
UniProt:Q9BYM8 RBCK1	1	RBCK1 [cytosol] (R-HSA-976018)	0.725	6
UniProt:Q9H0F6 SHARPIN	1	SHARPIN [cytosol] (R-HSA-5212666)	0.725	4
UniProt:Q9Y6K9 IKBKG	12	IKBKG [nucleoplasm] (R-HSA-4755413) SUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG D406V [cytosol] (R-HSA-5262943) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG 420Wro447 [cytosol] (R-HSA-5262978) Ub-285-IKBKG [cytosol] (R-HSA-741397) K63polyUb-NEMO [cytosol] (R-HSA-202530) IKBKG [cytosol] (R-HSA-168108)	0.669	3
UniProt:Q96EP0 RNF31	1	RNF31 [cytosol] (R-HSA-5212660)	0.643	3
UniProt:Q8UYL3 Q8UYL3			0.641	3
UniProt:P20333 TNFRSF1B	3	TNFRSF1B [plasma membrane] (R-HSA-5661484) TNFRSF1B(27-?) [plasma membrane] (R-HSA-6785037) TNFRSF1B [specific granule membrane] (R-HSA-6806149)	0.609	2
UniProt:Q16623 STX1A	6	STX1A [plasma membrane] (R-HSA-6794231) STX1A [plasma membrane] (R-HSA-449128) STX1A(?-288) [plasma membrane] (R-HSA-5246518) STX1A(1-?) [cytosol] (R-HSA-3065964) STX1A [cytosol] (R-HSA-9609866) STX1A [endoplasmic reticulum membrane] (R-HSA-9609878)	0.601	4
UniProt:Q9DHW0 Q9DHW0			0.558	2
UniProt:O75459 PAGE1			0.556	3
UniProt:Q92482 AQP3	1	AQP3 [plasma membrane] (R-HSA-431723)	0.556	3
UniProt:Q9H7M9 VISTA			0.556	3
UniProt:Q6ZMZ0 RNF19B	1	RNF19B [cytosol] (R-HSA-975969)	0.556	3
UniProt:Q16585 SGCB			0.556	3
UniProt:Q8N386 LRC25			0.556	3
UniProt:Q8IUN9 CLEC10A	1	CLEC10A [plasma membrane] (R-HSA-1472863)	0.556	3
UniProt:Q15849 SLC14A2	1	SLC14A2 [plasma membrane] (R-HSA-444115)	0.556	3
UniProt:Q5JX71 F209A			0.556	3
UniProt:O43300 LRRTM2	1	LRRTM2 [plasma membrane] (R-HSA-6797966)	0.556	3
UniProt:P00387 CYB5R3	3	CYB5R3(27-301) [extracellular region] (R-HSA-6806205) CYB5R3(27-301) [azurophil granule lumen] (R-HSA-6799217) MyrG-CYB5R3(2-301) [mitochondrial outer membrane] (R-HSA-198771)	0.556	3
UniProt:Q8TBE3 FNDC9			0.556	3
UniProt:Q6NSX1 CCD70			0.556	3
UniProt:Q53GL0 PKHO1			0.556	3
UniProt:Q6PEW1 ZCH12			0.556	3
UniProt:Q8WWF3 SSMM1			0.556	3
UniProt:Q8N6L0 KASH5			0.556	3
UniProt:Q8N4L2 PP4P2			0.556	3
UniProt:Q6UXG8-3 Q6UXG83			0.556	3
UniProt:Q8IYJ2-2 C10ORF67			0.556	3
UniProt:Q8WV48 CC107			0.556	3
UniProt:O95471 CLDN7	2	CLDN7 [plasma membrane] (R-HSA-420004) CLDN7 [cell junction] (R-HSA-421241)	0.556	3
UniProt:P27105 STOM	4	STOM [plasma membrane] (R-HSA-6806258) STOM [specific granule membrane] (R-HSA-6799569) STOM [tertiary granule membrane] (R-HSA-6800960) STOM [azurophil granule membrane] (R-HSA-6800997)	0.556	3
UniProt:O15393-2 TMPRSS2			0.556	3
UniProt:O14863 ZNT4			0.556	3
UniProt:Q9BXK5 B2L13			0.556	3
UniProt:Q9HC36 MRM3	1	RNMTL1 [mitochondrial matrix] (R-HSA-6793067)	0.556	3
UniProt:O15552 FFAR2	1	FFAR2 [plasma membrane] (R-HSA-443944)	0.556	3
UniProt:Q96BA8 CREB3L1	7	CREB3L1(427-519) [Golgi membrane] (R-HSA-8874139) CREB3L1 [Golgi membrane] (R-HSA-8874155) CREB3L1(1-426) [Golgi membrane] (R-HSA-8874153) CREB3L1 [endoplasmic reticulum membrane] (R-HSA-8874157) CREB3L1(1-375) [cytosol] (R-HSA-8874215) CREB3L1(376-426) [Golgi membrane] (R-HSA-8874213) CREB3L1(1-375) [nucleoplasm] (R-HSA-8874222)	0.556	3
UniProt:Q96RD7 PANX1	1	PANX1 [plasma membrane] (R-HSA-375344)	0.556	3
UniProt:P21580 TNFAIP3	1	TNFAIP3 [cytosol] (R-HSA-688989)	0.527	2
UniProt:Q60769	1	Tnfaip3 [cytosol] (R-MMU-688989)	0.499	2
UniProt:P25118	1	Tnfrsf1a [plasma membrane] (R-MMU-66344)	0.499	3
UniProt:Q60855	7	Ripk1 [cytosol] (R-MMU-6783197) Ripk1 [cytosol] (R-MMU-6783308) Ripk1 [cytosol] (R-MMU-5212664) Ripk1 [cytosol] (R-MMU-5212671) phospho-Ripk1 [cytosol] (R-MMU-5218872) Ripk1 [cytosol] (R-MMU-937021) Ripk1 [cytosol] (R-MMU-168651)	0.499	3
UniProt:O89110	6	Casp8 [mitochondrial outer membrane] (R-MMU-351828) Casp8 [mitochondrial outer membrane] (R-MMU-351869) Casp8 [cytosol] (R-MMU-3465404) Casp8 [cytosol] (R-MMU-57031) Casp8 [cytosol] (R-MMU-75975) Casp8 [cytosol] (R-MMU-76158)	0.499	2
UniProt:Q3U0V2	1	Tradd [cytosol] (R-MMU-66376)	0.499	2
UniProt:O88351	2	phospho-Ikbkb [cytosol] (R-MMU-202506) Ikbkb [cytosol] (R-MMU-168114)	0.499	3

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