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TNF(1-76) [plasma membrane]
Stable Identifier
R-HSA-8863120
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Icon
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Death Receptor Signalling (Homo sapiens)
TNF signaling (Homo sapiens)
Regulation of TNFR1 signaling (Homo sapiens)
SPPL2a/b cleaves TNF(1-76) (Homo sapiens)
TNF(1-76) trimer [plasma membrane] (Homo sapiens)
TNF(1-76) [plasma membrane] (Homo sapiens)
TNF-alpha is cleaved by ADAM17 (TACE) (Homo sapiens)
TNF(1-76) trimer [plasma membrane] (Homo sapiens)
TNF(1-76) [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01375 TNF
Gene Names
TNF, TNFA, TNFSF2
Chain
chain:1-233, chain:1-39, chain:1-35, chain:50-, chain:52-, chain:77-233
Reference Genes
BioGPS Gene:7124 TNF
COSMIC (genes):TNF TNF
CTD Gene:7124 TNF
dbSNP Gene:7124 TNF
ENSEMBL:ENSG00000204490 TNF
ENSEMBL:ENSG00000206439 TNF
ENSEMBL:ENSG00000223952 TNF
ENSEMBL:ENSG00000228321 TNF
ENSEMBL:ENSG00000228849 TNF
ENSEMBL:ENSG00000230108 TNF
ENSEMBL:ENSG00000232810 TNF
HGNC:11892 TNF
KEGG Gene (Homo sapiens):7124 TNF
Monarch:7124 TNF
NCBI Gene:7124 TNF
OMIM:191160 TNF
Reference Transcript
RefSeq:NM_000594.3 TNF
Other Identifiers
0002450619
11721577_at
17006659
17026267
17027794
17030620
17033337
17035418
17038117
17040712
1852_at
1A8M
1TNF
207113_s_at
259_s_at
2902417
2902418
2902420
2902421
2902423
2902424
2AZ5
2E7A
2TUN
2ZJC
2ZPX
3ALQ
3IT8
3L9J
3WD5
4G3Y
4TSV
4TWT
4Y6O
5M2I
5M2J
5M2M
5MU8
5TSW
5UUI
5WUX
5YOY
7124
8118142
8177983
8179263
A0A140T922
A_14_P110091
A_14_P125975
A_23_P376488
A_24_P50759
AAA36758
AAA61198
AAA61200
AAC03542
AAD18091
AAF71992
AAH28148
AAL47581
AAO21132
AB088112
AB103618
AB202113
ADV31546
AF043342
AF098751
AF129756
AHJ25918
AHJ25919
AHJ25920
AHJ25921
AHJ25922
AHJ25923
AHJ25924
AHJ25925
AK314960
AQY77148
AQY77150
AY066019
AY214167
BA000025
BAB63396
BAC54944
BAE78639
BAF31279
BAG37464
BC028148
CAA25650
CAA26669
CAA75070
CAA78745
CCDS4702
CH471081
CTQ86082
EAX03424
ENSG00000204490
ENSG00000206439
ENSG00000223952
ENSG00000228321
ENSG00000228849
ENSG00000230108
ENSG00000232810
ENSP00000365290
ENSP00000372988
ENSP00000389490
ENSP00000389492
ENSP00000392858
ENSP00000398698
ENSP00000410668
ENST00000376122
ENST00000383496
ENST00000412275
ENST00000420425
ENST00000443707
ENST00000448781
ENST00000449264
ENST00000449264.2
EntrezGene:7124
EntrezGene:TNF
g10835154_3p_a_at
GE59636
GO:0000122
GO:0000165
GO:0000185
GO:0000187
GO:0000278
GO:0001774
GO:0001819
GO:0001891
GO:0001932
GO:0001934
GO:0001937
GO:0002020
GO:0002376
GO:0002439
GO:0002740
GO:0002876
GO:0002925
GO:0003674
GO:0003677
GO:0005125
GO:0005164
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005623
GO:0005737
GO:0005768
GO:0005886
GO:0005887
GO:0005975
GO:0006006
GO:0006357
GO:0006412
GO:0006464
GO:0006629
GO:0006810
GO:0006919
GO:0006950
GO:0006952
GO:0006954
GO:0006955
GO:0006959
GO:0007010
GO:0007049
GO:0007155
GO:0007165
GO:0007249
GO:0007254
GO:0007267
GO:0007275
GO:0008150
GO:0008219
GO:0008283
GO:0008625
GO:0008630
GO:0009056
GO:0009058
GO:0009615
GO:0009651
GO:0009790
GO:0009887
GO:0009897
GO:0009986
GO:0010033
GO:0010628
GO:0010629
GO:0010693
GO:0010803
GO:0010888
GO:0014068
GO:0015031
GO:0016020
GO:0016021
GO:0016192
GO:0019221
GO:0019899
GO:0022607
GO:0030154
GO:0030198
GO:0030316
GO:0030730
GO:0030866
GO:0031334
GO:0031410
GO:0031622
GO:0031663
GO:0032715
GO:0032722
GO:0032729
GO:0032755
GO:0032757
GO:0032800
GO:0033138
GO:0033209
GO:0034116
GO:0034330
GO:0034641
GO:0035509
GO:0040011
GO:0042127
GO:0042531
GO:0042592
GO:0042742
GO:0042802
GO:0043065
GO:0043068
GO:0043122
GO:0043123
GO:0043226
GO:0043242
GO:0043243
GO:0043280
GO:0043406
GO:0043491
GO:0043507
GO:0043525
GO:0044212
GO:0044281
GO:0044403
GO:0045071
GO:0045080
GO:0045121
GO:0045123
GO:0045410
GO:0045416
GO:0045429
GO:0045598
GO:0045599
GO:0045662
GO:0045668
GO:0045670
GO:0045672
GO:0045732
GO:0045785
GO:0045860
GO:0045892
GO:0045893
GO:0045930
GO:0045944
GO:0045994
GO:0046325
GO:0046330
GO:0046427
GO:0048143
GO:0048566
GO:0048646
GO:0048661
GO:0048856
GO:0048870
GO:0050708
GO:0050715
GO:0050727
GO:0050729
GO:0050754
GO:0050766
GO:0050768
GO:0050796
GO:0050806
GO:0050807
GO:0050830
GO:0050877
GO:0050890
GO:0050900
GO:0050901
GO:0050995
GO:0051000
GO:0051023
GO:0051044
GO:0051091
GO:0051092
GO:0051173
GO:0051222
GO:0051384
GO:0051798
GO:0051897
GO:0051966
GO:0055037
GO:0055085
GO:0060252
GO:0060557
GO:0060559
GO:0060664
GO:0060693
GO:0061048
GO:0065003
GO:0070374
GO:0070886
GO:0071222
GO:0071230
GO:0071316
GO:0071407
GO:0071550
GO:0071677
GO:0071803
GO:0072577
GO:0072659
GO:0090197
GO:0097190
GO:0097191
GO:0097527
GO:0150078
GO:1900222
GO:1901224
GO:1901671
GO:1902004
GO:1903078
GO:1903140
GO:1903347
GO:1904707
GO:1904996
GO:1904999
GO:2000010
GO:2000304
GO:2000334
GO:2000343
GO:2000351
GO:2000377
GO:2000778
GO:2001240
HGNC:11892
HQ201306
ILMN_1728106
IPR002959
IPR006052
IPR006053
IPR008983
IPR021184
KF887965
KF887966
KF887967
KF887968
KF887969
KF887970
KF887971
KF887972
KY500676
KY500678
LN874317
M10988
M16441
M26331
MIM:157300
MIM:191160
MIM:600807
MIM:611162
NM_000594
NP_000585
PF00229
PH_hs_0012958
PR01234
PR01235
Q5STB3
SM00207
TC06000371.hg
TC06002714.hg
TC6_apd_hap1000036.hg
TC6_cox_hap2000067.hg
TC6_dbb_hap3000058.hg
TC6_mann_hap4000059.hg
TC6_mcf_hap5000053.hg
TC6_qbl_hap6000058.hg
TC6_ssto_hap7000054.hg
TNF
TNF-201
TNF-202
TNF-203
TNF-204
TNF-205
TNF-207
TNF-208
UPI000000D745
X01394
X02910
X02910_at
Y14768
Z15026
Participant Of
hasComponent
TNF(1-76) trimer [plasma membrane]
Other forms of this molecule
TNF(52-76) [extracellular region]
TNF(1-34) [plasma membrane]
TNF(77-233) [extracellular region]
TNF(1-233) [plasma membrane]
Inferred To
TNF(1-76) [plasma membrane] (Bos taurus)
TNF(1-76) [plasma membrane] (Canis familiaris)
TNF(1-76) [plasma membrane] (Danio rerio)
TNF(1-76) [plasma membrane] (Mus musculus)
TNF(1-76) [plasma membrane] (Rattus norvegicus)
TNF(1-76) [plasma membrane] (Sus scrofa)
Ghost homologue of TNF(1-76) [plasma membrane] (Xenopus tropicalis)
Cross References
RefSeq
NP_000585.2
ZINC - World Drugs
TNFA_HUMAN
OpenTargets
ENSG00000232810
ZINC - Substances
TNFA_HUMAN
ZINC - Biogenic
TNFA_HUMAN
ZINC target
P01375
PRO
P01375
PDB
4TWT
,
3IT8
,
4TSV
,
2AZ5
,
5WUX
,
5M2I
,
2TUN
,
2E7A
,
5M2M
,
3L9J
,
5YOY
,
4G3Y
,
1A8M
,
5TSW
,
3WD5
,
5M2J
,
2ZPX
,
5UUI
,
3ALQ
,
5MU8
,
4Y6O
,
1TNF
,
2ZJC
ZINC - Investigational
TNFA_HUMAN
ZINC - Metabolites
TNFA_HUMAN
GeneCards
P01375
Orphanet
16877
ZINC - Predictions - Purchasable
TNFA_HUMAN
HMDB Protein
HMDBP02070
Interactors (49)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P19438 TNFRSF1A
3
TNFRSF1A [plasma membrane]
(R-HSA-5675738)
TNFRSF1A(41-201) [extracellular region]
(R-HSA-6785048)
TNFRSF1A(22-455) [plasma membrane]
(R-HSA-66344)
0.937
15
UniProt:Q13546 RIPK1
9
PolyUb-RIPK1 [cytosol]
(R-HSA-6783197)
K48polyUb-RIPK1 [cytosol]
(R-HSA-6783308)
K63pUb-K377-RIP1 [cytosol]
(R-HSA-5212672)
RIPK1(1-324) [cytosol]
(R-HSA-5212664)
p-S-RIPK1 [cytosol]
(R-HSA-5218872)
RIPK1 [cytosol]
(R-HSA-168651)
RIPK1(325-671) [cytosol]
(R-HSA-5212671)
RIPK1 [endosome membrane]
(R-HSA-450326)
K63polyUb-RIPK1 [cytosol]
(R-HSA-937021)
0.837
9
UniProt:Q12933 TRAF2
5
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
TRAF2 [nucleoplasm]
(R-HSA-8862199)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
TRAF2 [cytosol]
(R-HSA-66370)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
0.788
9
UniProt:Q13490 BIRC2
5
K48pUb-BIRC2 [cytosol]
(R-HSA-5675479)
K63polyUb-BIRC2 [cytosol]
(R-HSA-5668512)
BIRC2(1-372) [cytosol]
(R-HSA-202913)
BIRC2 [cytosol]
(R-HSA-50847)
BIRC2(373-618) [cytosol]
(R-HSA-202931)
0.788
5
UniProt:P01375 TNF
5
TNF(1-34) [plasma membrane]
(R-HSA-8863367)
TNF(52-76) [extracellular region]
(R-HSA-8863375)
TNF(1-76) [plasma membrane]
(R-HSA-8863120)
TNF(77-233) [extracellular region]
(R-HSA-976821)
TNF(1-233) [plasma membrane]
(R-HSA-66220)
0.73
3
UniProt:Q15628 TRADD
1
TRADD [cytosol]
(R-HSA-66376)
0.725
7
UniProt:Q9H0F6 SHARPIN
1
SHARPIN [cytosol]
(R-HSA-5212666)
0.725
4
UniProt:Q9BYM8 RBCK1
1
RBCK1 [cytosol]
(R-HSA-976018)
0.725
6
UniProt:Q9Y6K9 IKBKG
12
IKBKG [nucleoplasm]
(R-HSA-4755413)
SUMO1-K277,K309-IKBKG [nucleoplasm]
(R-HSA-4755449)
IKBKG D406V [cytosol]
(R-HSA-5262943)
IKBKG L153R [cytosol]
(R-HSA-5262879)
IKBKG E391* [cytosol]
(R-HSA-5262924)
IKBKG C417R [cytosol]
(R-HSA-5262858)
IKBKG R173G [cytosol]
(R-HSA-5262966)
IKBKG R175P [cytosol]
(R-HSA-5262916)
IKBKG *420Wro*447 [cytosol]
(R-HSA-5262978)
IKBKG [cytosol]
(R-HSA-168108)
K63polyUb-NEMO [cytosol]
(R-HSA-202530)
Ub-285-IKBKG [cytosol]
(R-HSA-741397)
0.669
3
UniProt:Q96EP0 RNF31
1
RNF31 [cytosol]
(R-HSA-5212660)
0.643
3
UniProt:Q8UYL3 Q8UYL3
0.641
3
UniProt:P20333 TNFRSF1B
3
TNFRSF1B [specific granule membrane]
(R-HSA-6806149)
TNFRSF1B(27-?) [plasma membrane]
(R-HSA-6785037)
TNFRSF1B [plasma membrane]
(R-HSA-5661484)
0.609
2
UniProt:Q9DHW0 Q9DHW0
0.558
2
UniProt:P21580 TNFAIP3
1
TNFAIP3 [cytosol]
(R-HSA-688989)
0.527
2
UniProt:Q60769
1
TNFAIP3 [cytosol]
(R-MMU-688989)
0.499
2
UniProt:P25118
1
TNFRSF1A(22-455) [plasma membrane]
(R-MMU-66344)
0.499
3
UniProt:Q60855
6
PolyUb-RIPK1 [cytosol]
(R-MMU-6783197)
K48polyUb-RIPK1 [cytosol]
(R-MMU-6783308)
phospho-p-S-RIPK1 [cytosol]
(R-MMU-5218872)
K63polyUb-RIPK1 [cytosol]
(R-MMU-937021)
RIPK1(325-671) [cytosol]
(R-MMU-5212671)
RIPK1 [cytosol]
(R-MMU-168651)
0.499
3
UniProt:O89110
6
CASP8(217-374) [mitochondrial outer membrane]
(R-MMU-351869)
CASP8(1-374) [cytosol]
(R-MMU-3465404)
CASP8(385-479) [mitochondrial outer membrane]
(R-MMU-351828)
CASP8(1-479) [cytosol]
(R-MMU-57031)
CASP8(385-479) [cytosol]
(R-MMU-76158)
CASP8(217-374) [cytosol]
(R-MMU-75975)
0.499
2
UniProt:Q3U0V2
1
TRADD [cytosol]
(R-MMU-66376)
0.499
2
UniProt:O88351
2
phospho-p-S177,S181-IKBKB [cytosol]
(R-MMU-202506)
IKBKB [cytosol]
(R-MMU-168114)
0.499
3
UniProt:Q92482 AQP3
1
AQP3 [plasma membrane]
(R-HSA-431723)
0.488
2
UniProt:Q9H7M9 VISTA
0.488
2
UniProt:Q96RD7 PANX1
1
PANX1 [plasma membrane]
(R-HSA-375344)
0.488
2
UniProt:Q6ZMZ0 RNF19B
1
RNF19B [cytosol]
(R-HSA-975969)
0.488
2
UniProt:Q16585 SGCB
0.488
2
UniProt:Q96BA8 CREB3L1
7
CREB3L1(427-519) [Golgi membrane]
(R-HSA-8874139)
CREB3L1 [Golgi membrane]
(R-HSA-8874155)
CREB3L1(1-426) [Golgi membrane]
(R-HSA-8874153)
CREB3L1 [endoplasmic reticulum membrane]
(R-HSA-8874157)
CREB3L1(1-375) [cytosol]
(R-HSA-8874215)
CREB3L1(376-426) [Golgi membrane]
(R-HSA-8874213)
CREB3L1(1-375) [nucleoplasm]
(R-HSA-8874222)
0.488
2
UniProt:Q8N386 LRC25
0.488
2
UniProt:Q8IUN9 CLEC10A
1
CLEC10A [plasma membrane]
(R-HSA-1472863)
0.488
2
UniProt:Q15849 SLC14A2
1
SLC14A2 [plasma membrane]
(R-HSA-444115)
0.488
2
UniProt:Q5JX71 F209A
0.488
2
UniProt:P00387 CYB5R3
3
CYB5R3(27-301) [extracellular region]
(R-HSA-6806205)
MyrG-CYB5R3(2-301) [mitochondrial outer membrane]
(R-HSA-198771)
CYB5R3(27-301) [azurophil granule lumen]
(R-HSA-6799217)
0.488
2
UniProt:Q8TBE3 FNDC9
0.488
2
UniProt:Q6NSX1 CCD70
0.488
2
UniProt:Q53GL0 PKHO1
0.488
2
UniProt:Q16623 STX1A
6
STX1A [plasma membrane]
(R-HSA-6794231)
STX1A [plasma membrane]
(R-HSA-449128)
STX1A(?-288) [plasma membrane]
(R-HSA-5246518)
STX1A(1-?) [cytosol]
(R-HSA-3065964)
STX1A [cytosol]
(R-HSA-9609866)
STX1A [endoplasmic reticulum membrane]
(R-HSA-9609878)
0.488
2
UniProt:Q8WWF3 SSMM1
0.488
2
UniProt:Q6PEW1 ZCH12
0.488
2
UniProt:Q8N6L0 KASH5
0.488
2
UniProt:Q8N4L2 PP4P2
0.488
2
UniProt:Q6UXG8-3 Q6UXG83
0.488
2
UniProt:Q8WV48 CC107
0.488
2
UniProt:Q8IYJ2-2 C10ORF67
0.488
2
UniProt:O95471 CLDN7
2
CLDN7 [cell junction]
(R-HSA-421241)
CLDN7 [plasma membrane]
(R-HSA-420004)
0.488
2
UniProt:P27105 STOM
4
STOM [azurophil granule membrane]
(R-HSA-6800997)
STOM [tertiary granule membrane]
(R-HSA-6800960)
STOM [plasma membrane]
(R-HSA-6806258)
STOM [specific granule membrane]
(R-HSA-6799569)
0.488
2
UniProt:O15393-2 TMPRSS2
0.488
2
UniProt:O14863 ZNT4
0.488
2
UniProt:Q9BXK5 B2L13
0.488
2
UniProt:Q9HC36 MRM3
1
RNMTL1 [mitochondrial matrix]
(R-HSA-6793067)
0.488
2
UniProt:O15552 FFAR2
1
FFAR2 [plasma membrane]
(R-HSA-443944)
0.488
2
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