Reactome | TNF(1-76) [plasma membrane]

TNF(1-76) [plasma membrane]

Stable Identifier

R-HSA-8863120

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Icon

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P01375 TNF

Gene Names

TNF, TNFA, TNFSF2

Chain

chain:1-233, chain:1-39, chain:1-35, chain:50-, chain:52-, chain:77-233

Reference Genes

BioGPS Gene:7124 TNF

COSMIC (genes):TNF TNF

CTD Gene:7124 TNF

dbSNP Gene:7124 TNF

ENSEMBL:ENSG00000204490.3 TNF

ENSEMBL:ENSG00000206439.5 TNF

ENSEMBL:ENSG00000223952.3 TNF

ENSEMBL:ENSG00000228321.3 TNF

ENSEMBL:ENSG00000228849.3 TNF

ENSEMBL:ENSG00000230108.3 TNF

ENSEMBL:ENSG00000232810 TNF

ENSEMBL:ENSG00000232810.4 TNF

HGNC:11892 TNF

KEGG Gene (Homo sapiens):7124 TNF

Monarch:7124 TNF

NCBI Gene:7124 TNF

OMIM:191160 TNF

Reference Transcript

RefSeq:NM_000594.3 TNF

Other Identifiers

0002450619

11721577_at

17006659

17026267

17027794

17030620

17033337

17035418

17038117

17040712

1852_at

207113_PM_s_at

207113_s_at

259_s_at

2902417

2902418

2902420

2902421

2902423

2902424

7124

8118142

8177983

8179263

A_14_P110091

A_14_P125975

A_23_P376488

A_24_P50759

GE59636

GO:0000122

GO:0000165

GO:0000278

GO:0000976

GO:0001666

GO:0001774

GO:0001775

GO:0001819

GO:0001891

GO:0001932

GO:0001934

GO:0001937

GO:0002020

GO:0002037

GO:0002376

GO:0002439

GO:0002523

GO:0002526

GO:0002637

GO:0002719

GO:0002876

GO:0002925

GO:0003009

GO:0003012

GO:0003013

GO:0003085

GO:0003674

GO:0003677

GO:0005102

GO:0005125

GO:0005164

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005768

GO:0005886

GO:0005887

GO:0005975

GO:0006006

GO:0006091

GO:0006351

GO:0006355

GO:0006357

GO:0006629

GO:0006766

GO:0006915

GO:0006919

GO:0006952

GO:0006954

GO:0006955

GO:0006959

GO:0007010

GO:0007154

GO:0007155

GO:0007165

GO:0007249

GO:0007254

GO:0007623

GO:0008150

GO:0008285

GO:0008625

GO:0008630

GO:0009314

GO:0009410

GO:0009612

GO:0009615

GO:0009617

GO:0009651

GO:0009887

GO:0009897

GO:0009986

GO:0010033

GO:0010459

GO:0010573

GO:0010628

GO:0010629

GO:0010693

GO:0010888

GO:0012501

GO:0014068

GO:0014070

GO:0014823

GO:0016020

GO:0016021

GO:0016192

GO:0019722

GO:0019899

GO:0023052

GO:0030154

GO:0030163

GO:0030198

GO:0030316

GO:0030730

GO:0030866

GO:0031047

GO:0031334

GO:0031410

GO:0031622

GO:0031642

GO:0031663

GO:0031667

GO:0032496

GO:0032715

GO:0032722

GO:0032724

GO:0032729

GO:0032731

GO:0032741

GO:0032755

GO:0032757

GO:0033138

GO:0033209

GO:0034116

GO:0034138

GO:0034330

GO:0035509

GO:0036211

GO:0042060

GO:0042127

GO:0042311

GO:0042531

GO:0042742

GO:0042802

GO:0043025

GO:0043065

GO:0043066

GO:0043068

GO:0043122

GO:0043123

GO:0043154

GO:0043226

GO:0043242

GO:0043243

GO:0043280

GO:0043406

GO:0043410

GO:0043491

GO:0043507

GO:0043525

GO:0043537

GO:0045071

GO:0045121

GO:0045123

GO:0045429

GO:0045471

GO:0045598

GO:0045599

GO:0045662

GO:0045668

GO:0045670

GO:0045672

GO:0045732

GO:0045760

GO:0045785

GO:0045840

GO:0045860

GO:0045892

GO:0045893

GO:0045930

GO:0045944

GO:0045994

GO:0046325

GO:0046330

GO:0046427

GO:0048143

GO:0048566

GO:0048661

GO:0048856

GO:0048870

GO:0050708

GO:0050727

GO:0050729

GO:0050766

GO:0050768

GO:0050793

GO:0050796

GO:0050806

GO:0050807

GO:0050830

GO:0050877

GO:0050890

GO:0050900

GO:0050901

GO:0050966

GO:0050995

GO:0051000

GO:0051044

GO:0051046

GO:0051091

GO:0051092

GO:0051173

GO:0051222

GO:0051384

GO:0051798

GO:0051897

GO:0051966

GO:0055037

GO:0055085

GO:0060252

GO:0060557

GO:0060559

GO:0060664

GO:0060693

GO:0061044

GO:0061048

GO:0065003

GO:0065008

GO:0070374

GO:0070886

GO:0071219

GO:0071222

GO:0071230

GO:0071300

GO:0071316

GO:0071346

GO:0071407

GO:0071677

GO:0071803

GO:0072577

GO:0072659

GO:0090324

GO:0097190

GO:0097191

GO:0097237

GO:0097421

GO:0097527

GO:0098542

GO:0120190

GO:0140014

GO:0140460

GO:0150078

GO:0150129

GO:1900017

GO:1900222

GO:1901224

GO:1901554

GO:1901647

GO:1901671

GO:1902004

GO:1902565

GO:1902895

GO:1903078

GO:1903140

GO:1903223

GO:1903347

GO:1903721

GO:1903799

GO:1904646

GO:1904707

GO:1904996

GO:1904999

GO:1905242

GO:1990268

GO:2000010

GO:2000272

GO:2000334

GO:2000343

GO:2000347

GO:2000351

GO:2000377

GO:2000573

GO:2001234

GO:2001238

GO:2001240

GO:2001272

HMNXSV003051425

ILMN_1728106

PH_hs_0012958

TC06000371.hg

TC06002714.hg

TC6_apd_hap1000036.hg

TC6_cox_hap2000067.hg

TC6_dbb_hap3000058.hg

TC6_mann_hap4000059.hg

TC6_mcf_hap5000053.hg

TC6_qbl_hap6000058.hg

TC6_ssto_hap7000054.hg

X02910_at

g10835154_3p_a_at

Participates

as a component of

TNF(1-76) trimer [plasma membrane] (Homo sapiens)

Other forms of this molecule

TNF(52-76) [extracellular region]

TNF(1-34) [plasma membrane]

TNF(77-233) [extracellular region]

TNF(1-233) [plasma membrane]

Inferred To

dl3 [plasma membrane] (Danio rerio)

TNF(1-76) [plasma membrane] (Danio rerio)

TNF(1-76) [plasma membrane] (Xenopus tropicalis)

TNF [plasma membrane] (Bos taurus)

TNF [plasma membrane] (Canis familiaris)

TNF [plasma membrane] (Sus scrofa)

Homologues of TNF(1-76) [plasma membrane] (Danio rerio)

Tnf [plasma membrane] (Mus musculus)

Tnf [plasma membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_000585.2

ZINC - World Drugs

TNFA_HUMAN

OpenTargets

ENSG00000232810

ZINC - Substances

TNFA_HUMAN

ZINC target

P01375

ZINC - Biogenic

TNFA_HUMAN

PRO

P01375

PDB

5M2J, 6X86, 7ATB, 5YOY, 6OOZ, 6X83, 1A8M, 6OP0, 2ZJC, 6RMJ, 7KPA, 1TNF, 7AT7, 6X85, 5MU8, 7KPB, 5M2I, 7ASY, 5WUX, 2AZ5, 3WD5, 2TUN, 6X81, 5UUI, 2ZPX, 6X82, 7JRA, 4Y6O, 7KP9, 2E7A, 4G3Y, 5TSW, 3L9J, 6OOY, 5M2M, 3IT8, 3ALQ, 4TSV, 4TWT

ZINC - Investigational

TNFA_HUMAN

ZINC - Metabolites

TNFA_HUMAN

GeneCards

P01375

HPA

ENSG00000232810-TNF

Ensembl

ENSP00000392858, ENSG00000204490, ENSP00000372988, ENSP00000410668, ENSG00000228321, ENSP00000398698, ENST00000420425, ENST00000383496, ENSG00000206439, ENST00000449264, ENST00000448781, ENSG00000232810, ENSG00000230108, ENST00000412275, ENSP00000365290, ENST00000443707, ENSP00000389490, ENSP00000389492, ENSG00000228849, ENSG00000223952, ENST00000376122

Pharos - Targets

P01375

ZINC - Predictions - Purchasable

TNFA_HUMAN

Orphanet

16877

HMDB Protein

HMDBP02070

Interactors (52)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P19438 TNFRSF1A	2	TNFRSF1A(30-45) [plasma membrane] (R-HSA-5675738) TNFRSF1A(41-201) [extracellular region] (R-HSA-6785048)	0.934	15
UniProt:Q13546 RIPK1	15	K48polyUb-RIPK1 [cytosol] (R-HSA-6783308) PolyUb-RIPK1 [cytosol] (R-HSA-6783197) RIPK1 D324N [cytosol] (R-HSA-9693930) RIPK1 D324Y [cytosol] (R-HSA-9693931) RIPK1 D324V [cytosol] (R-HSA-9693927) RIPK1 D324H [cytosol] (R-HSA-9693922) RIPK1 [plasma membrane] (R-HSA-937073) K48polyUb-K571,K604,K627-RIPK1 [cytosol] (R-HSA-9796639) K63poUb, M1polyUb-RIPK1 [cytosol] (R-HSA-9793681) RIPK1(1-324) [cytosol] (R-HSA-5212664) RIPK1(325-671) [cytosol] (R-HSA-5212671) p-S166-RIPK1 [cytosol] (R-HSA-5218872) K63polyUb-RIPK1 [cytosol] (R-HSA-937021) RIPK1 [endosome membrane] (R-HSA-450326) RIPK1 [cytosol] (R-HSA-168651)	0.837	9
UniProt:Q13490 BIRC2	5	K63polyUb-BIRC2 [cytosol] (R-HSA-5668512) BIRC2(1-372) [cytosol] (R-HSA-202913) BIRC2(373-618) [cytosol] (R-HSA-202931) K48pUb-BIRC2 [cytosol] (R-HSA-5675479) BIRC2 [cytosol] (R-HSA-50847)	0.788	5
UniProt:Q12933 TRAF2	5	TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.788	9
UniProt:P01375 TNF	5	TNF(52-76) [extracellular region] (R-HSA-8863375) TNF(1-34) [plasma membrane] (R-HSA-8863367) TNF(1-76) [plasma membrane] (R-HSA-8863120) TNF(77-233) [extracellular region] (R-HSA-976821) TNF(1-233) [plasma membrane] (R-HSA-66220)	0.73	3
UniProt:Q9BYM8 RBCK1	1	RBCK1 [cytosol] (R-HSA-976018)	0.725	6
UniProt:Q9H0F6 SHARPIN	1	SHARPIN [cytosol] (R-HSA-5212666)	0.725	4
UniProt:Q15628 TRADD	1	TRADD [cytosol] (R-HSA-66376)	0.725	7
UniProt:Q9Y6K9 IKBKG	12	monoSUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG [nucleoplasm] (R-HSA-4755413) IKBKG D406V [cytosol] (R-HSA-5262943) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG 420Wro447 [cytosol] (R-HSA-5262978) K63polyUb-IKBKG [cytosol] (R-HSA-202530) Ub-285-IKBKG [cytosol] (R-HSA-741397) IKBKG [cytosol] (R-HSA-168108)	0.669	3
UniProt:Q96EP0 RNF31	1	RNF31 [cytosol] (R-HSA-5212660)	0.643	3
UniProt:Q8UYL3 Q8UYL3			0.641	3
UniProt:P20333 TNFRSF1B	3	TNFRSF1B(27-?) [plasma membrane] (R-HSA-6785037) TNFRSF1B [specific granule membrane] (R-HSA-6806149) TNFRSF1B [plasma membrane] (R-HSA-5661484)	0.609	2
UniProt:Q16623 STX1A	5	STX1A [plasma membrane] (R-HSA-449128) STX1A(?-288) [plasma membrane] (R-HSA-5246518) STX1A(1-?) [cytosol] (R-HSA-3065964) STX1A [cytosol] (R-HSA-9609866) STX1A [endoplasmic reticulum membrane] (R-HSA-9609878)	0.601	4
UniProt:Q9DHW0 Q9DHW0			0.558	2
UniProt:O75459 PAGE1			0.556	3
UniProt:Q92482 AQP3	1	AQP3 [plasma membrane] (R-HSA-431723)	0.556	3
UniProt:Q9H7M9 VISTA			0.556	3
UniProt:Q96RD7 PANX1	1	PANX1 [plasma membrane] (R-HSA-375344)	0.556	3
UniProt:Q6ZMZ0 RNF19B	1	RNF19B [cytosol] (R-HSA-975969)	0.556	3
UniProt:Q16585 SGCB			0.556	3
UniProt:Q8N386 LRC25			0.556	3
UniProt:Q15849 SLC14A2	1	SLC14A2 [plasma membrane] (R-HSA-444115)	0.556	3
UniProt:Q5JX71 F209A			0.556	3
UniProt:O43300 LRRTM2	1	LRRTM2 [plasma membrane] (R-HSA-6797966)	0.556	3
UniProt:P00387 CYB5R3	3	CYB5R3(27-301) [azurophil granule lumen] (R-HSA-6799217) CYB5R3(27-301) [extracellular region] (R-HSA-6806205) MyrG-CYB5R3(2-301) [mitochondrial outer membrane] (R-HSA-198771)	0.556	3
UniProt:Q8TBE3 FNDC9			0.556	3
UniProt:Q6NSX1 CCD70			0.556	3
UniProt:Q53GL0 PKHO1			0.556	3
UniProt:Q6PEW1 ZCH12			0.556	3
UniProt:Q8WWF3 SSMM1			0.556	3
UniProt:Q8N6L0 KASH5			0.556	3
UniProt:Q8N4L2 PP4P2			0.556	3
UniProt:Q6UXG8-3 Q6UXG83			0.556	3
UniProt:Q8IYJ2-2 C10ORF67			0.556	3
UniProt:Q8WV48 CC107			0.556	3
UniProt:O95471 CLDN7	2	CLDN7 [cell junction] (R-HSA-421241) CLDN7 [plasma membrane] (R-HSA-420004)	0.556	3
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:P27105 STOM	4	STOM [azurophil granule membrane] (R-HSA-6800997) STOM [plasma membrane] (R-HSA-6806258) STOM [specific granule membrane] (R-HSA-6799569) STOM [tertiary granule membrane] (R-HSA-6800960)	0.556	3
UniProt:O15552 FFAR2	1	FFAR2 [plasma membrane] (R-HSA-443944)	0.556	3
UniProt:O15393-2 TMPRSS2			0.556	3
UniProt:O14863 ZNT4			0.556	3
UniProt:Q9BXK5 B2L13			0.556	3
UniProt:Q8IUN9 CLEC10A	1	CLEC10A [plasma membrane] (R-HSA-1472863)	0.556	3
UniProt:Q9HC36 MRM3	1	RNMTL1 [mitochondrial matrix] (R-HSA-6793067)	0.556	3
UniProt:Q96BA8 CREB3L1	7	CREB3L1 [Golgi membrane] (R-HSA-8874155) CREB3L1(427-519) [Golgi membrane] (R-HSA-8874139) CREB3L1(1-426) [Golgi membrane] (R-HSA-8874153) CREB3L1 [endoplasmic reticulum membrane] (R-HSA-8874157) CREB3L1(1-375) [cytosol] (R-HSA-8874215) CREB3L1(376-426) [Golgi membrane] (R-HSA-8874213) CREB3L1(1-375) [nucleoplasm] (R-HSA-8874222)	0.556	3
UniProt:P21580 TNFAIP3	1	TNFAIP3 [cytosol] (R-HSA-688989)	0.527	2
UniProt:Q60769	1	TNFAIP3 [cytosol] (R-MMU-688989)	0.499	2
UniProt:P25118	1	TNFRSF1A(30-45) [plasma membrane] (R-MMU-5675738)	0.499	3
UniProt:O89110	6	Casp8 [cytosol] (R-MMU-3465404) Casp8 [mitochondrial outer membrane] (R-MMU-351869) Casp8 [mitochondrial outer membrane] (R-MMU-351828) Casp8 [cytosol] (R-MMU-76158) Casp8 [cytosol] (R-MMU-75975) Casp8 [cytosol] (R-MMU-57031)	0.499	2
UniProt:Q3U0V2	1	TRADD [cytosol] (R-MMU-66376)	0.499	2
UniProt:O88351	2	phospho-p-S177,S181-IKBKB [cytosol] (R-MMU-202506) IKBKB [cytosol] (R-MMU-168114)	0.499	3
UniProt:Q60855	9	K48polyUb-RIPK1 [cytosol] (R-MMU-6783308) PolyUb-RIPK1 [cytosol] (R-MMU-6783197) K48polyUb-K571,K604,K627-RIPK1 [cytosol] (R-MMU-9796639) K63poUb, M1polyUb-RIPK1 [cytosol] (R-MMU-9793681) RIPK1(1-324) [cytosol] (R-MMU-5212664) RIPK1(325-671) [cytosol] (R-MMU-5212671) phospho-p-S166-RIPK1 [cytosol] (R-MMU-5218872) K63polyUb-RIPK1 [cytosol] (R-MMU-937021) RIPK1 [cytosol] (R-MMU-168651)	0.499	3

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