Reactome | CRBN [cytosol]

CRBN [cytosol]

Stable Identifier

R-HSA-8863300

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Protein cereblon, CRBN_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q16531 DDB1

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - Potential therapeutics for SARS (Homo sapiens)
        
        CRBN binds IMiDs (Homo sapiens)
        
        CRBN [cytosol] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
26188093	Cereblon is recruited to aggresome and shows cytoprotective effect against ubiquitin-proteasome system dysfunction Yamada, H, Sawamura, N, Matsumoto, K, Asahi, T, Wakabayashi, S	Biochem. Biophys. Res. Commun.	2015

External Reference Information

External Reference

UniProt:Q96SW2 CRBN

Gene Names

CRBN, AD-006

Chain

chain:1-442

Reference Genes

BioGPS Gene:51185 CRBN

COSMIC (genes):CRBN CRBN

CTD Gene:51185 CRBN

dbSNP Gene:51185 CRBN

ENSEMBL:ENSG00000113851 CRBN

ENSEMBL_homo_sapiens_GENE:ENSG00000113851.16 CRBN

HGNC:30185 CRBN

KEGG Gene (Homo sapiens):51185 CRBN

Monarch:51185 CRBN

NCBI Gene:51185 CRBN

OMIM:609262 CRBN

UCSC:Q96SW2 CRBN

Reference Transcript

Other Identifiers

11721433_a_at

11721434_a_at

11748834_a_at

16950238

218142_PM_s_at

218142_s_at

222533_PM_at

222533_at

2660656

2660657

2660661

2660662

2660664

2660666

2660669

2660671

2660678

2660685

2660686

2660687

2660690

2660691

45275_at

45276_g_at

51185

65753_at

65754_g_at

72971_at

8085081

A_23_P250930

A_24_P351435

GE82102

GO:0005515

GO:0005634

GO:0005737

GO:0005829

GO:0016020

GO:0016567

GO:0023052

GO:0030163

GO:0030177

GO:0031333

GO:0031334

GO:0031464

GO:0034766

GO:0035641

GO:0036211

GO:0043161

GO:0043226

GO:0044325

GO:0046872

GO:0048471

GO:0055085

GO:0065003

HMNXSV003002589

Hs.18925.0.S2_3p_at

PH_hs_0001671

TC03001123.hg

g10047097_3p_a_at

Participates

as a component of

CRBN:IMiDs [cytosol] (Homo sapiens)

as an input of

CRBN binds IMiDs (Homo sapiens)

Cross References

RefSeq

NP_057386.2, NP_001166953.1

Guide to Pharmacology - Targets

3086

OpenTargets

ENSG00000113851

GeneCards

Q96SW2

HPA

ENSG00000113851-CRBN

Ensembl

ENST00000432408, ENSP00000231948, ENST00000231948, ENSP00000412499, ENSG00000113851

PRO

Q96SW2

Pharos - Targets

Q96SW2

PDB

8OIZ, 8D7U, 5FQD, 8D7V, 6UML, 8TNR, 6XK9, 7LPS, 8D7W, 6BN8, 6BN7, 5V3O, 8G66, 8D80, 8U15, 5HXB, 8D7Y, 6H0G, 6BOY, 6H0F, 4M91, 8D7X, 6BN9, 8OJH, 7BQU, 4TZ4, 8U17, 7U8F, 8TNQ, 8CVP, 8D81, 7BQV, 8DEY, 8D7Z, 6BNB, 8TNP, 8U16

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q16531 DDB1	1	DDB1 [nucleoplasm] (R-HSA-53489)	0.723	4
UniProt:Q9P286 PAK5	2	PAK7 [plasma membrane] (R-HSA-211555) PAK5 [cytosol] (R-HSA-428459)	0.666	4
UniProt:Q7L5N1 COPS6	2	COPS6 [nucleoplasm] (R-HSA-5697026) COPS6 [cytosol] (R-HSA-416961)	0.648	4
UniProt:Q13619 CUL4A	2	CUL4A [nucleoplasm] (R-HSA-976006) G76-NEDD8-K705-CUL4A [nucleoplasm] (R-HSA-8952514)	0.648	6
UniProt:P48729 CSNK1A1	2	CSNK1A1 [cytosol] (R-HSA-195263) CSNK1A1 [cilium] (R-HSA-5632507)	0.641	3
UniProt:A0A6Q8PF08 A0A6Q8PF08			0.556	3
UniProt:Q93062 RBPMS			0.556	3
UniProt:Q8IVT2 MISP			0.556	3
UniProt:Q96A83-2 Q96A832			0.556	3
UniProt:O14901 KLF11			0.556	3
IntAct:EBI-25847655 CCSB			0.556	3
UniProt:P62877 RBX1	2	RBX1 [nucleoplasm] (R-HSA-1234142) RBX1 [cytosol] (R-HSA-180582)	0.528	2
UniProt:Q92905 COPS5	2	COPS5 [nucleoplasm] (R-HSA-5697019) COPS5 [cytosol] (R-HSA-416963)	0.528	2
UniProt:Q13620 CUL4B	2	CUL4B [nucleoplasm] (R-HSA-975973) G76-NEDD8-K859-CUL4B [nucleoplasm] (R-HSA-8952522)	0.527	5