Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
CDK5R1(99-307) [cytosol]
Stable Identifier
R-HSA-8863415
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p25
Icon
Locations in the PathwayBrowser for interactor UniProt:P43356 MAGA2
Expand all
Disease (Homo sapiens)
Diseases of programmed cell death (Homo sapiens)
Defective Intrinsic Pathway for Apoptosis (Homo sapiens)
Neurodegenerative Diseases (Homo sapiens)
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models (Homo sapiens)
CDK5 binds p25 (Homo sapiens)
CDK5R1(99-307) [cytosol] (Homo sapiens)
Calpain cleaves p35 to p25 (Homo sapiens)
CDK5R1(99-307) [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15078 CDK5R1
Gene Names
CDK5R1, CDK5R, NCK5A
Chain
initiator methionine:, chain:2-307, chain:99-307
Reference Genes
BioGPS Gene:8851 CDK5R1
COSMIC (genes):CDK5R1 CDK5R1
CTD Gene:8851 CDK5R1
dbSNP Gene:8851 CDK5R1
ENSEMBL:ENSG00000176749 CDK5R1
ENSEMBL_homo_sapiens_GENE:ENSG00000176749.9 CDK5R1
HGNC:1775 CDK5R1
KEGG Gene (Homo sapiens):8851 CDK5R1
Monarch:8851 CDK5R1
NCBI Gene:8851 CDK5R1
OMIM:603460 CDK5R1
UCSC:Q15078 CDK5R1
Reference Transcript
RefSeq:XM_011525438.2 CDK5R1
RefSeq:XM_017025281.1 CDK5R1
RefSeq:NM_003885.2 CDK5R1
Other Identifiers
11722022_s_at
16833159
204995_PM_at
204995_at
204996_PM_s_at
204996_s_at
36273_at
3717776
3717777
3717780
3717781
3717782
3717783
3717784
3717785
3717786
3717788
3717789
55644_at
799_at
8006409
800_g_at
8851
A_14_P109471
A_14_P116589
A_14_P125186
A_23_P141467
A_33_P3226985
GE60061
GO:0000079
GO:0000226
GO:0000307
GO:0001764
GO:0002020
GO:0003779
GO:0003824
GO:0004672
GO:0005509
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005886
GO:0006351
GO:0006355
GO:0006886
GO:0006914
GO:0007010
GO:0007155
GO:0007158
GO:0007213
GO:0007411
GO:0007413
GO:0007420
GO:0008092
GO:0009792
GO:0012501
GO:0014069
GO:0016020
GO:0016192
GO:0016241
GO:0016301
GO:0016533
GO:0016740
GO:0018105
GO:0018107
GO:0019901
GO:0021549
GO:0021722
GO:0021766
GO:0021799
GO:0021819
GO:0023052
GO:0030154
GO:0030182
GO:0030295
GO:0030424
GO:0030425
GO:0030426
GO:0031116
GO:0031175
GO:0031594
GO:0032956
GO:0034330
GO:0035235
GO:0035255
GO:0036211
GO:0042995
GO:0043005
GO:0043014
GO:0043025
GO:0043197
GO:0043204
GO:0043226
GO:0043231
GO:0043292
GO:0043525
GO:0043539
GO:0045296
GO:0045664
GO:0045892
GO:0046875
GO:0048013
GO:0048471
GO:0048487
GO:0048511
GO:0048856
GO:0048870
GO:0051015
GO:0061001
GO:0061575
GO:0065003
GO:0070315
GO:0070507
GO:0090314
GO:0098693
GO:0098772
GO:0098793
GO:0140096
HMNXSV003051329
Hs.93597.0.S2_3p_at
ILMN_1730928
ILMN_2062271
PH_hs_0005140
TC17000377.hg
X80343_at
g4502736_3p_a_at
Participates
as an output of
Calpain cleaves p35 to p25 (Homo sapiens)
as an input of
CDK5 binds p25 (Homo sapiens)
as a component of
CDK5:p25 [cytosol] (Homo sapiens)
Other forms of this molecule
MyrG-CDK5R1(2-307) [plasma membrane]
CDK5R1(99-307) [nucleoplasm]
MyrG-CDK5R1(2-98) [plasma membrane]
Cross References
RefSeq
NP_003876.1
,
XP_011523740.1
,
XP_016880770.1
OpenTargets
ENSG00000176749
ZINC - Substances
CD5R1_HUMAN
GeneCards
Q15078
HPA
ENSG00000176749-CDK5R1
ZINC target
Q15078
Ensembl
ENSG00000176749
,
ENSP00000318486
,
ENST00000313401
PRO
Q15078
Pharos - Targets
Q15078
ZINC - Predictions - Purchasable
CD5R1_HUMAN
PDB
1UNG
,
6LDP
,
7VDS
,
7VDQ
,
3O0G
,
1UNL
,
7CNG
,
1UNH
,
7VDP
,
7VDR
,
1H4L
Interactors (25)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q00535 CDK5
4
CDK5 [nucleoplasm]
(R-HSA-8863586)
p-Y15,S159-CDK5 [nucleoplasm]
(R-HSA-6805249)
CDK5 [cytosol]
(R-HSA-180064)
p-Y15-CDK5 [cytosol]
(R-HSA-399809)
0.94
15
UniProt:Q6ZMQ8-2 AATK
0.593
6
UniProt:Q9ULW0 TPX2
2
TPX2 [cytosol]
(R-HSA-8853407)
TPX2 [nucleoplasm]
(R-HSA-2564700)
0.556
3
UniProt:Q96E17 RAB3C
2
GGC-RAB3C [cytosol]
(R-HSA-8874012)
RAB3C [cytosol]
(R-HSA-8873684)
0.556
3
UniProt:O94983-5 CAMTA2
0.556
3
UniProt:Q9HC98-4 NEK6
0.556
3
UniProt:Q96QH2 PRAM
0.556
3
UniProt:Q02978 SLC25A11
1
SLC25A11 [mitochondrial inner membrane]
(R-HSA-198451)
0.556
3
UniProt:P49184 DNASE1L1
2
DNASE1L1 [extracellular region]
(R-HSA-6806320)
DNASE1L1 [specific granule lumen]
(R-HSA-6799554)
0.556
3
UniProt:Q8NCR3 MFI
0.556
3
UniProt:Q5JR59 MTUS2
0.556
3
UniProt:A2RUH7 MBPHL
0.556
3
UniProt:Q9BT49 THAP7
0.556
3
UniProt:Q9BQ29 Q9BQ29
0.556
3
UniProt:P43356 MAGA2
0.556
3
UniProt:Q8N2W9 PIAS4
2
PIAS4 [nucleoplasm]
(R-HSA-2993789)
monoSUMO1-K35-PIAS4 [nucleoplasm]
(R-HSA-3968415)
0.556
3
UniProt:Q9NPC7 MYNN
0.556
3
UniProt:Q6UXH1-2 CRELD2
0.556
3
UniProt:P26715 KLRC1
1
KLRC1 [plasma membrane]
(R-HSA-3006545)
0.556
3
UniProt:P16422 EPCAM
1
EPCAM [plasma membrane]
(R-HSA-375068)
0.556
3
UniProt:P24941 CDK2
5
p-Y15-CDK2 [nucleoplasm]
(R-HSA-187905)
p-CDK2 [nucleoplasm]
(R-HSA-68370)
CDK2 [cytosol]
(R-HSA-157440)
CDK2 [nucleoplasm]
(R-HSA-68365)
p-T160-CDK2 [nucleoplasm]
(R-HSA-187967)
0.527
2
UniProt:Q96EY5 MVB12A
1
MVB12A [endosome membrane]
(R-HSA-8955360)
0.527
2
UniProt:O43583 DENR
0.527
2
UniProt:Q01581 HMGCS1
1
HMGCS1 [cytosol]
(R-HSA-191329)
0.527
2
UniProt:Q9NPD8 UBE2T
3
Ub-C86-UBE2T [nucleoplasm]
(R-HSA-8864217)
UBE2T [nucleoplasm]
(R-HSA-420942)
MonoUb-K91,K182-UBE2T [nucleoplasm]
(R-HSA-6785362)
0.527
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text