DAB2 binds LRP2

Stable Identifier
R-HSA-8863472
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

DAB2 interacts by coimmunoprecipitation with the LDL receptor family protein LRP2 (also known as Megalin) through the third intracellular NPxY motif of LRP2 (Gallagher et al, 2004; Oleinikov et al, 2000). While the functional significance of this interaction remains to be elucidated, Dab2-/- mice show phenotypes consistent with reduced LRP2 endocytosis, suggesting that the interaction may help to sort LRP2 into clathrin-coated pits (Morris et al, 2002; Mishra et al, 2002).

Literature References
PubMed ID Title Journal Year
11927540 Dual roles for the Dab2 adaptor protein in embryonic development and kidney transport

Morris, SM, Tallquist, MD, Rock, CO, Cooper, JA

EMBO J. 2002
10769163 Cytosolic adaptor protein Dab2 is an intracellular ligand of endocytic receptor gp600/megalin

Oleinikov, AV, Zhao, J, Makker, SP

Biochem. J. 2000
15134832 The adaptor disabled-2 binds to the third psi xNPxY sequence on the cytoplasmic tail of megalin

Gallagher, H, Oleinikov, AV, Fenske, C, Newman, DJ

Biochimie 2004
12234931 Disabled-2 exhibits the properties of a cargo-selective endocytic clathrin adaptor

Mishra, SK, Keyel, PA, Hawryluk, MJ, Agostinelli, NR, Watkins, SC, Traub, LM

EMBO J. 2002
Participants
Participant Of
Orthologous Events
Authored
Reviewed