Reactome: A Curated Pathway Database

DAB2 binds LRP2

Stable Identifier
R-HSA-8863472
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

DAB2 interacts by coimmunoprecipitation with the LDL receptor family protein LRP2 (also known as Megalin) through the third intracellular NPxY motif of LRP2 (Gallagher et al, 2004; Oleinikov et al, 2000). While the functional significance of this interaction remains to be elucidated, Dab2-/- mice show phenotypes consistent with reduced LRP2 endocytosis, suggesting that the interaction may help to sort LRP2 into clathrin-coated pits (Morris et al, 2002; Mishra et al, 2002).

Literature References
Participants
Participant Of
Orthologous Events