Reactome: A Curated Pathway Database

CDK5:p25 translocates to the nucleus

Stable Identifier
R-HSA-8863587
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The complex of CDK5 and p25 can translocate to the nucleus (Patrick et al. 1999). Nuclear envelope fragmentation, initiated by CDK5:p25-mediate phosphorylation of lamin A and B1, increases access of the CDK5:p25 complex to nuclear proteins (Chang et al. 2011).

Literature References
Participants
Participant Of
Disease
Diseases
Name Identifier Synonyms
Alzheimer's disease 10652 AD, Alzheimers dementia, Alzheimer disease