AGFG1 binds VAMP7

Stable Identifier
R-HSA-8863718
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

AGFG1, also known as HRB (HIV-1 Rev-binding), is a clathrin adaptor and ArfGAP that interacts with the R-SNARE VAMP7 to mediate its endocytosis from the plasma membrane (Pryor et al, 2008; Chaineau et al, 2008). AGFG1 also interacts with a number of other endocytic proteins such as EPS15, EPS15R, FCHos and ITSNs (Doria et al, 1999; Salcini et al, 1997; Schmid et al, 2006; Umasankar et al, 2012).

Literature References
PubMed ID Title Journal Year
22484487 Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning

Umasankar, PK, Sanker, S, Thieman, JR, Chakraborty, S, Wendland, B, Tsang, M, Traub, LM

Nat. Cell Biol. 2012
18819912 Role of HRB in clathrin-dependent endocytosis

Chaineau, M, Danglot, L, Proux-Gillardeaux, V, Galli, T

J. Biol. Chem. 2008
9303539 Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module

Salcini, AE, Confalonieri, S, Doria, M, Santolini, E, Tassi, E, Minenkova, O, Cesareni, G, Pelicci, PG, Di Fiore, PP

Genes Dev 1997
10613896 The eps15 homology (EH) domain-based interaction between eps15 and hrb connects the molecular machinery of endocytosis to that of nucleocytosolic transport

Doria, M, Salcini, AE, Colombo, E, Parslow, TG, Pelicci, PG, Di Fiore, PP

J. Cell Biol. 1999
18775314 Molecular basis for the sorting of the SNARE VAMP7 into endocytic clathrin-coated vesicles by the ArfGAP Hrb

Pryor, PR, Jackson, L, Gray, SR, Edeling, MA, Thompson, A, Sanderson, CM, Evans, PR, Owen, DJ, Luzio, JP

Cell 2008
16903783 Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly

Schmid, EM, Ford, MG, Burtey, A, Praefcke, GJ, Peak-Chew, SY, Mills, IG, Benmerah, A, McMahon, HT

PLoS Biol. 2006
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